A first glimpse of the influenza replication machine
...lymerase and to look for weak points that could be targeted by drugs," says Darren Hart, whose team participated in the research at EMBL Grenoble. "But no one could get enough protein to analyse its structure. We developed a way to use robots to screen tens of thousands of experimental conditions and discover...Experimental Biology 2007: Today's Research, Tomorrow's Health, April 28-May 2
...lopments in vascular biology; pharmacogenomics and targeted therapies; stem cells for therapeutics; and novel therapies based on molecules of the innate immune system. The American Society for Pharmacology and Experimental Therapeutics offers symposia on cannabinoids (a chemical compound in cannabis or mar...Killing the messenger RNA -- But which one?
...fferent groups of about 80 genes each likely to be targeted by the two versions of the molecule. They then selected three genes from each group for a closer look, testing to see whether their expression was in fact altered, up or down, by the microRNAs. It was. Then they chose one potentially affected gene ...The Biology and Fisheries of the Slipper Lobster
... distribution of those particular species that are targeted species or by-products of other fisheries. The book takes a comparative approach to understanding fisheries in different regions of the world and examines management plans that have failed and those that have succeeded. The text includes an identi...Novel test identifies lymphoma patients likely to respond to new therapy
...niquely susceptible to a newly developed molecular targeted therapy. As a result, physicians organizing clinic...have a characteristic signature in which the genes targeted by the BCL6 protein are either expressed (turned on) or not expressed. The researchers used state-o...MIT study shows genetic link for schizophrenia
...ake people susceptible to schizophrenia and may be targeted in future treatments for the psychiatric illness, according to MIT and Japanese researchers. The work, by scientists from MIT's Picower Institute for Learning and Memory and Japan's RIKEN Brain Science Institute, will be reported in the early onlin...Fetal heart-cell enzyme important in onset of heart failure
...med at regulating blood pressure, but very few are targeted at the heart-muscle cells themselves. About 5 million Americans are living with CHF today, according to the American Heart Association. "To understand how to better treat heart disease at the cellular level is an important next step," says Epstein....The last wild hunt -- Deep-sea fisheries scrape bottom of the sea
... stocks and move on, we now see global declines of targeted species." Ironically, this highly destructive form of fishing would be unprofitable without heavy government support. Rashid Sumaila and Daniel Pauly of the University of British Columbia Fisheries Centre recently examined subsidies paid to bottom...FSU researchers determine a critical factor in workings of proteins
.... "A protein can have multiple targets or can be targeted by multiple molecules," said Professor Huan-Xiang Zhou, who serves on the faculty of FSU's School of Computational Science and department of physics. "Rapid association between proteins is crucial in a wide array of biological processes, such as the ...News tips from the Journal of Neuroscience
...Ns were fluorescently labeled, whereas their axons targeted the same cluster of glomeruli. For the OR111 subfamily, each OSN expressed a single OR, but a few OSNs coexpressed OR111 and OR103 subfamily members, and OR1031 was always coexpressed with OR1032/1035. Such dual receptor expression has also been seen...DNA ends: Common tool, different job
...ntification of this new RPA-like complex, which is targeted to a specific region of the genome, suggests that multiple RPA-like complexes have evolved, each making individual contributions to genomic stability," says the study's lead author Vicki Lundblad, Ph.D., a professor in the Molecular Cell Biology Labo...Putting an old drug to a new use
... step on the way from laboratory to clinic will be targeted pharmacological modifications of the compound to separate nifedipine's effect on iron metabolism from its established action on blood pressure. "Our discovery is an excellent example of how the combination of basic research and the expertise of cl...Emerging research heralds new era of breast cancer management
...ery, radiotherapy, chemotherapy, hormonal therapy, targeted therapywill continue to evolve as our knowledge of the disease grows. S. Eva Singletary, M.D., F.A.C.S, a surgeon from the University of Texas M. D. Anderson Cancer Center in Houston, discusses the latest research in breast cancer screening and ma...Manipulating nature: Scientists query wildlife birth-control method
...: "Immunocontraception alters the gene pool of the targeted species because those animals who are unresponsive are genetically unusual individuals," he says. "The job of the immunological system is to combat disease-causing organisms. But there is a danger that the selected minority might be more susceptib...Cold Spring Harbor Laboratory scientists discover new gene that prevents multiple types of cancer
...ch for a tumor suppressive network that means more targeted and effective cancer therapy in the future," said CSHL Associate Professor Alea Mills, Ph.D. The study, headed by Mills, was published in the February issue of Cell. Specifically, Mills' discovery identifies CHD5, a protein that prevents cancer, a...Discovery could lead to better control of hemorrhagic fever viruses
...viruses, which is necessary for the development of targeted antiviral drugs that block those parts, but not the parts involved in iron uptake. The findings of Choe and colleagues also suggest that iron supplements may reduce the severity of New World virus infections. Past studies have shown that when the ...The Biology and Fisheries of the Slipper Lobster
... distribution of those particular species that are targeted species or by-products of other fisheries. The book takes a comparative approach to understanding fisheries in different regions of the world and examines management plans that have failed and those that have succeeded. The text includes an identi...Man-made proteins could be more useful than real ones
... real proteins but won't be degraded by enzymes or targeted by the immune system, as natural proteins are. The researchers, led by Howard Hughes Medical Institute (HHMI) professor Alanna Schepartz, report their findings in the February 14, 2007, issue of the Journal of the American Chemical Society, publis...Study finds flaws in cancer clinical trials
...aid. But today's new treatments, which can include targeted therapies that slow tumor progression, are often tested in less advanced cancer and in combinations "and it can be hard to answer the question of whether patients are doing better than expected," he said. In their study, Vickers, Howard Scher, M.D....Adult stem cells to repair hearts damaged by severe coronary artery disease investigated
...into which the stem cells would be injected. "This targeted approach increases the treatment's effectiveness by delivering the stem cells exactly where they are needed." Schaer uses the Johnson & Johnsons NOGA XP Cardiac Navigation System to identify ischemic but viable regions of the heart as targets for cel...