News tips from the Journal of Neuroscience
..., Gorczyca et al. addressed the complex process of targeted membrane addition at the larval Drosophila neuromuscular junction, particularly the specialized, multilayered postsynaptic membrane called the subsynaptic reticulum (SSR). The authors used the guanylate kinaselike domain of the fly scaffolding prot...Central and peripheral signals set the circadian liver clock
...rmed a genome-wide scan of the expression of genes targeted by BMAL1 in the presence and absence of Dox, they found arrhythmic expression of most of the targeted clock genes when the liver clocks stopped, as expected. However, some genes, including the known clo...Cholera pathogen reveals how bacteria generate energy to live
...oteins that do similar work, some of them might be targeted by novel antibiotics. "An inhibitor or drug would be specific," she said. "You could kill the bacteria without doing anything to the human host." But Barquera believes that the most important benefits of her research could develop in ways that cann...Novel laboratory technique nudges genes into activity
...her RNA such as what occurs when messenger RNA is targeted during RNA interference. "Thats what everyone is familiar with," he said. "But the idea of RNA being used as a sort of nucleic acid modulator of chromosomes, at the level of the chromosome itself, is novel and unexpected, and its going to take some g...Smokers quit after damage to brain region
... therapies, Bechara said, including possible drugs targeted to a region that "no one paid attention to." "There is a lot of potential for pharmacological developments," Bechara said. Any treatment would need to preserve the beneficial functions of the insula. But Bechara noted that the region appears to be ...Drug strategy makes cancer genes get lost in translation
...erhard Wagner of Harvard Medical School. Therapies targeted at translation might have general use in tackling many forms of cancer, regardless of its genetic origin, given that the uncontrolled growth of cells is a general characteristic of the disease, he added. The new findings establish a "possible new s......w, the scientists wanted to know, is the G protein targeted so quickly and precisely to activate the channel? Reuveny and his team found that the receptor and G protein are physically bound together in a complex, allowing the process to be finely tuned. When the receptor receives a chemical message from th...Estrogen interferes with immune surveillance in breast cancer
...d to estrogen. When these breast cancer cells were targeted by natural killer cells, they were efficiently killed off, even when significant levels of estrogen and estrogen receptor were present. Estrogens are known to cause only a few types of cancers, Shapiro said. PI-9 also has been implicated in other ...News tips from the Journal of Neuroscience
... the weaker synapses containing NMDA receptors are targeted for elimination. 3. Rejecting Unfair Offers in the Ultimate Game Michael Koenigs and Daniel Tranel Most of us feel a flash of anger at being treated unfairly, particularly when it comes to money. But can you make a rational decision that salv...JCI table of contents: Jan. 18, 2007
...agues found that in cultured human cells, ExoT was targeted for destruction by the host protein Cbl-b. More importantly, ExoT was shown to be important for bacterial dissemination in mice infected with P. aeruginosa and mice lacking Cbl-b were more susceptible to both intranasal and systemic infection with P....Can engineered immune cells stop AIDS?
...d not other types of cells, to achieve the desired targeted delivery. With a group of USC biomedical engineering students and Caltech biologists, Wang is experimenting with CD20 as a target antigen for human B cells. His strategy, published in the August 1, 2006 issue of Proceedings of the National Academ...Training breathing muscles improves swimming muscles' performance
... swimming endurance and breathing capacity through targeted training of the respiratory muscles, researchers at the University at Buffalo have shown. In this pioneering work, subjects who followed a resistance-breathing training protocol (breathing load) improved their respiratory muscle strength and their...Researchers develop new strategy for the treatment of CML
...so develop," said Grant. "Addition of a second, targeted agent that potentiates the activity of dasatinib may reduce the leukemic burden further, and thereby reduce, or possibly even prevent the emergence of drug resistance. If validated, this concept could have significant implications for the treatment o...Quantum biology -- Powerful computer models reveal key biological mechanism
...a "nanoswitch" for a variety of applications, from targeted drug delivery to genomics and proteomics to sensors. The research is part of a burgeoning discipline called "quantum biology," which taps the skyrocketing power of today's high-performance computers to precisely model complex biological processes. ...Small molecule offers big hope against cancer
...accelerates our understanding of and action around targeted cancer treatments," said Dr. Philip Branton, Scientic Director of the CIHR Institute of Cancer....Novel approach to cancer drug given major boost
...cts. This work has the potential to provide a more targeted approach to drug therapy with fewer adverse effect...als are most likely to respond to the drug." This targeted therapy is based on five years of research by Professor Tavar and Dr Paul England. The research has ...Nanotech safety needs specific government risk research strategy and funding
...minimum of $100 million over the next two years in targeted risk research in order to lay a strong, science-based foundation for safe nanotechnology." According to Maynard's analysis, despite investing more than $1 billion annually on nanotechnology research, U.S. government spending on highly relevant nanote...JCI table of contents: January 2, 2007
... cells can be selectively, efficiently, and safely targeted for potential therapies for conditions such as atherosclerosis or insulin resistance. TITLE: Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata AUTHOR CONTACT: Mikael Pittet Massach...Green Chemical Reactor Engineering -- XI
...he basis of computational fluid dynamics (CFD) and targeted experimentation in mock-ups. This will lead to the synthesis of new materials, better use of natural resources, minimization of non-utilizable by-products, sensors and instrumentation. Excellent examples of these new types of reactors are both the mu...Dengue and other hemorrhagic fevers: Towards a first potential treatment
..., in vitro, that Dengue-virus infection of certain targeted cells of the immune system (the dendritic cells) triggered an inflammatory reaction, stimulating these same target cells to overproduce metalloproteinases (gelatinolytic matrix metalloproteinases MMP-9) and secrete them into the cellular supernatant...