Cellular pathway yields potential new weapon in vaccine arsenal
... test the pathway's effectiveness, the researchers targeted an influenza antigen directly to autophagosomes. They found that they were able to increase antigen presentation by MHC class II molecules, subsequently boosting helper T cell recognition of viral antigens. "This targeting pathway could be very effic...Structure of iron regulatory protein-RNA complex solved
...search Institute in Oakland, Calif., just as drugs targeted to the three-dimensional protein structure emerged...olded in the IRP1 complex is a gift to drug design targeted to 3-D RNA structure -- a developing goal in this century." The researchers believe the details of...Mayo researcher discovers target site for developing mosquito pesticides
...elieve the cysteine and arginine residues could be targeted by a pesticide that would not affect humans and other mammals. "While a three-dimensional model of the mosquito enzyme acetylcholinesterase has been reported by other scientists, no mosquito-specific residue at the active site of acetylcholinesteras...Epigenetic drugs, promising for breast cancer treatment
...specific therapies, collectively termed "molecular targeted therapies". In the context of these new forms of treatment, epigenetic or transcriptional cancer therapy is clearly promising. Epigenetics refers to the function of DNA that does not depend on the coding DNA sequence itself but on the accessory mol...Tuberculosis: The bacillus takes refuge in adipose cells
...rk highlights the importance of the search for new targeted therapeutic weapons, such as new antibiotics, which must be able to reach the dormant bacillus that has been hiding in adipose cells without our knowing it....ACS News Service Weekly PressPac -- Dec. 13, 2006
...nthly publication, the scientists describe using a targeted proteomics approach to identify proteins adsorbed to the surface of silicone because those proteins have been identified as key components in local immune reactions to silicone. "Thus far we have identified the 30 most abundant proteins deposited on ...Quality not quantity important for immune response to HIV
...um of CTC responses, we may need to look at a more targeted vaccine."...Pair of microRNA molecules controls major oncogene in most common leukemia
...ive forms of the cancer. To determine which miRNAs targeted TCL1, they used microRNA-microchips and elaborate computer programs to identify miR-29 and miR-181. Regulation of TCL1 expression by these two miRNAs is relevant to all the three groups of cells studied, Pekarsky said. "You can look at the miRNA p...Herceptin plus chemotherapy significantly increases disease-free survival in breast cancer
Combining the molecularly targeted therapy Herceptin with chemotherapy in women with early stage breast cancer significantly improves disease-free survival for patients with a specific genetic mutation that results in very aggressive disease, a top UCLA researcher reported Thursday. ...Leibniz Prize winners 2007 announced
...ing contribution to the endeavour of directing the targeted differentiation of stem cells and thus solving one of the key problems of applied stem cell research. Magdalena Gtz studied biology in Zurich and Tbingen, where she obtained her doctorate in 1992. She declined several offers of professorship from S...Seeing a neurotoxin's deadly grip
...l." Thus, he said, engineered toxins could provide targeted treatments for a wide array of medical disorders."...Spelling out cancer on the nanoscale
...no-fluidic system to quickly measure the impact of targeted protein inhibitors in mice. A series of fine needle-aspirated samples was analyzed, confirming a decrease in oncoprotein levels. The new nano-fluidic system was also tested on human tumors by measuring the levels of MYC, BCL2, ERK, and AKT protein...Gene discovered by UNC researchers tied to pancreatic cancer
...discovery could lead to earlier diagnosis and more targeted treatments. In the United States, pancreatic cancer is the fourth leading cause of cancer death and the third leading cause of cancer death among people 40 to 59 years. Most people with the disease die within a year of diagnosis; about 95 percent of ...Antibody extends life of mice with breast cancer
...ibility of using the antibody as a vehicle for the targeted delivery of drugs to aid cancer diagnosis and therapy....Embryonic patterning makes the feathers fly
...set up a cultured embryonic chicken skin model and targeted a variety of potential downstream signaling pathways with specific inhibitors. They got their biggest hits with the so-called mitogen-activated protein kinase, or MAPK, pathway. Manipulating the MAPK pathway produced a wide repertoire of feather patt...Eculizumab is well-tolerated and shows significant improvement in PNH patients (Ph III)
...s the first investigational treatment specifically targeted for PNH and has the potential to significantly improve the quality of life for PNH patients. We are pleased that the FDA has allowed for expanded access of eculizumab to PNH patients," said Dr. Sarah Higgins, President of the PNH Research and Support...Research highlights how farmers' agri-environment schemes could do more for wildlife
... UK agri-environment schemes have worked well when targeted at the needs of such rare and localised species as corncrakes and stone curlews. However, being able to reverse the declines of more widespread species such as skylarks and yellowhammers will depend on better matching of habitat management to the d...Ebola-outbreak kills 5000 gorillas
...up to gorilla social group. This opens the door to targeted vaccination strategies that, by breaking the chain...ction wave also suggests that vaccination could be targeted just ahead of the advancing wave. The current lack of a vaccination program is not due to a lack o...MIT: Engineered yeast speeds ethanol production
...uthor on the paper. In this case, the researchers targeted two different transcription factors. They got their best results with a factor known as a TATA-binding protein, which when altered in three specific locations caused the over-expression overexpresion of at least a dozen genes, all of which were found......mber Gerald Fink, took a new approach. The team targeted two proteins that belong to a class of proteins called transcription factors. These proteins typically control large groups of genes, regulating when these genes are turned on or shut off. When the researchers altered a transcription factor called...