Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
...with a unique mechanism of action that exclusively targets and binds with high affinity to, and inhibits the activity of human RANK (receptor activator of nuclear factor kappa B) Ligand, the primary mediator of bone resorption. Amgen scientists have confirmed the essential role of RANK Ligand pathway in the...Running not swimming or biking is best kind of loading exercise for childrens bone growth
... such as prostaglandins and nitric oxide. Specific targets of mechanical loading include the L-type calcium channel (alpha 1C isoform), a gadolinium-sensitive stretch-activated channel, P2Y2 and P2X7 purinergic receptors, EP2 and EP4 prostanoid receptors, and the parathyroid hormone receptors. "One character...NIH funds first nationaL SNP genotyping center at Broad Institute
...xponentially as investigators prioritize potential targets for treatment and as members of afflicted families try to better estimate their risk for a particular condition." Many diseases can be traced to inherited differences in each individual's genes. The most common type of variation in the human genome...Marine Biological Laboratory summer investigator wins Nobel Prize in Chemistry
... Ubiquitin is a protein found within cells that targets other proteins for elimination. Scientists have long known that all cells manufacture and subsequently discard an array of proteins involved in a variety of cellular processes. Although many scientists over the years have focused their research on le...US Agency for International Development awards $34 million to Virginia Tech
...live crop in California. IPM identifies and targets crop pests such as invasive pests, insect-transmitted plant viruses, and harmful native pests, using a combination of tactics, including crop management, biological controls, and limited use of pesticides, to reduce both costs and ecological impacts....Report: How 10 top new technologies will help world reach globally-agreed goals by 2015
...s contamination; Bioinformatics to identify drug targets and to examine pathogen-host interactions; Nutrition-enriched crops to counter specific deficiencies, such as vitamin A-rich "Golden Rice" to improve health for millions without a balanced diet; Sequencing pathogen genomes to understand their bio...New study on smallpox in monkeys reveals tactics of a killer
...nses. Uncovering these mechanisms gives scientists targets for developing countermeasures to lessen or block the ability of the smallpox virus to cause disease. Experts believe that this new knowledge of how smallpox acts on cells could speed up development of smallpox countermeasures. Researchers will n...Where in the brain decisions are made
...e required to choose to glance at specific colored targets to receive sips of water. The computer program would analyze their responses and vary the parameters to elicit the same strategy. The researchers determined that the monkeys adopted the same strategy as humans--presumably reflecting the same neural p...Experimental drug prevents vaginal simian HIV transmission in monkeys Science study says
...ls, including difficulties getting the drug to all targets within mucosal membranes of the animals. In addition, the progesterone treatments and large doses of SHIV used to ensure near-universal infection of control monkeys could put the monkeys at an especially high risk of infection. The high drug doses us...Muscling in on a deadly cancer
...at develop the tumors. The genetic events might be targets for new drugs that could be tested on the mice. The disease, named alveolar rhabdomyosarcoma, "is a very mean childhood cancer," says study leader Mario Capecchi, co-chair of human genetics in the university's School of Medicine and an investigator...Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
... can ameliorate atrophy suggests a new set of drug targets for chemical intervention during cachexia, cancer, AIDS and other settings of atrophy," the authors conclude. "This is critically important because unfortunately there are currently no drugs approved for the treatment of skeletal muscle atrophy." ...Normal cells in tumors may aid cancer growth
...etic changes in stromal cells also may provide new targets for future anti-cancer drugs and present a new str...o be true, someone may someday develop a drug that targets stroma cells and prevents the cancer from spreading." Eng and her colleagues analyzed 134 tiss...Frontiers in cancer prevention research: Defeating cancer before it strikes
...evention relies heavily on: identifying promising targets for drug development; understanding how personal decisions are linked to cancer and identifying high-risk populations; developing pre-clinical drug-testing models; and tailoring prevention strategies to genetic profiles. WHEN: Saturday Wednes...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
...arrior" cells that orchestrate attacks on specific targets in the body, such as cancer cells and microorganisms. The finding could form the basis for new strategies for improving the efficacy of anti-cancer vaccines or preventing autoimmune diseases. Autoimmune diseases are those in which the imm...Are yeast cells bringing us a step closer in treating obesity?
...lic diseases. Indeed, these proteins could be good targets for new medicines to compensate for the surplus or shortage of a particular sugar. Yeast as model for humans The VIB scientists are conducting their research on yeast proteins. It often turns out that the proteins found in yeast have a similar vari...Genetics play role in response to most common asthma drug
...s may play a role in these differences. Albuterol targets the beta-2 adrenergic receptor molecules. As an asthma quick-relief medication, it relaxes the muscles in the airways and quickly opens up the air passages during an asthma attack, when airways are narrowed. BARGE was developed based on observations...Pesticides may promote Parkinson's disease and exercise may offer protection
...xin--6-hydroxydopamine (6-OHDA), which selectively targets dopamine neurons--directly into the corpus straitum, the region of the brain where dopamine projections normally end. This caused a much slower and progressive loss of dopamine neurons--a progression that started in the corpus straitum and then sprea...Sandbagging cancer in the bloodstream
...e distant organs. The potential treatment strategy targets this final step of the metastatic cascade--the exit of the metastatic cells from the bloodstream. "We know that the normal blood vessel wall is one final barrier that metastatic tumor cells must overcome, which allows them to find their way out of th...Bug's-eye-view of urinary tract reveals E.coli infection genes
...e during infection, researchers will have specific targets for the development of vaccines or therapeutic drugs designed to kill invading E. coli bacteria," Mobley adds.......plication of HIV. "HIV proteins are difficult drug targets because they can mutate rapidly to render small-molecule inhibitors inefficient," he said. "Such drugs typically bind only to a few amino acids in the protein, which the virus can easily alter by mutation. But in our approach, we could distribute the...