Yale and Pfizer launch visiting professorship pilot program
...hort circuits" in cancer cells can be used as drug targets to specifically stop cancer cells from growing. The new drugs Herceptin and Gleevac, are novel and specific agents for the treatment of cancer patients. There is a major effort at Pfizer and elsewhere to develop new agents of this type. Maihl...Researchers show how botulism toxin ensnares its target
...aving SNARE proteins are highly specific for their targets meaning that each toxin specifically recognizes and attacks one of three different neuronal SNARE proteins. Since most of these toxin proteases have virtually the same structures at the regions that perform the cleavage, or active sites, a key quest...Researchers discover new gene in colon cancer
... in suppressing colon cancer. These genes give us targets that we can aim for in the development of new drugs or gene therapies that may help us treat or prevent colon cancer," said Markowitz, who is also an investigator with the Howard Hughes Medical Institute. Lead authors on the paper are Min Yan of the ...Discovery of first demethylase molecule, a long-sought gene regulator
...es is any guide, the demethylases could one day be targets for cancer therapeutics. "These findings will impact every walk of biology," said David Allis of Rockefeller University, a leader in studying the regulation and biological roles of histone tags. "Histone modifications are highly dynamic on-off swit...Researchers discover a stem-cell switch lurking within leukemias
...so help explain why the cancer drug Gleevec, which targets the BCR-ABL enzyme, does not cure the disease, but...f BCR-ABL , the researchers hope to identify drug targets that can specifically eliminate the self-renewal capability of such cancers....An unusual RNA structure in the SARS virus offers a promising target for antiviral drugs
...thogens do and would be susceptible to a drug that targets s2m. Astroviruses, meanwhile, are a leading cause of gastrointestinal infections, second only to rotaviruses as a cause of childhood diarrhea. In developing countries, diarrhea is a major cause of death in children. A drug that blocks s2m could help ...Finding cures for tropical diseases: Is open source an answer?
...rs. Researchers can now identify promising protein targets and small sets of chemicals using computation alone."...University of Chicago researchers discovered that humans are a 'privileged' evolutionary lineage
...at affect brain size and behavior are preferential targets of selection during human evolution. Lahn and his colleagues now are focusing on these outlier genes, which may reveal more about how the human brain became bigger and better. For two of these outliers, ASPM and Microcephalin, previous work from Lahn...Vollum Institute discovery may unlock human genome
...llow you to take that factor and identify what its targets are, you would understand why that oncogene causes...on of dopamine-producing cells. By identifying the targets of the transcription factor, stem cells differentiated as dopamine cells could be developed to treat...The giant eagle of Middle Earth
...s. However, there is no evidence that humans were targets for this huge aerial predator. In the research paper, New Zealand researchers at Oxford University's Ancient Biomolecules Center run by Professor Alan Cooper extracted DNA from fossil eagle bones about 2000 years old. Dr Michael Bunce, who perfo...Put science at center of decision-making on third world development, experts tell UN
... leaders in 2000, the MDGs are clear, quantifiable targets to be achieved by 2015. The full Millennium Project will report later in January on strategies to reach all MDGs, including reducing poverty, hunger, disease, illiteracy, environmental degradation, and discrimination against women. Three years in pr...US researchers uncover the science behind the breast cancer protective effect of olive oil
...Herceptin), the monoclonal antibody treatment that targets the Her-2/neu gene and has helped to prolong the lives of many breast cancer patients. Lead researcher, Dr Javier Menendez, assistant professor at the Northwestern University Feinberg School of Medicine in Chicago and a research scientist with th...Scientists reveal molecular secrets of the malaria parasite
...efit biomedical scientists who are identifying new targets for vaccines that would impede the parasite during...roject will help vaccine researchers find the best targets against malaria," says scientist Neil Hall, the first author of the paper that appears in the Januar...The Louis-Jeantet-Prize for Medicine 2005
...igate how the specificity of Rho GTPases for their targets is controlled. To this end he plans to increase or diminish the expression of about 85 different human guanine nucleotide exchange factors (GEFs) that potentially interact with Rho GTPases and to test how they influence the migratory properties of tu...University of Pittsburgh receives award to study new theory of breast cancer development
...adjunct to conventional therapy one that directly targets tumor stem cells and the activity of their drug-resistant pumps."...Scientists decipher genome of fungus that can cause life-threatening infections
...s genome sequences and their analysis provide many targets for vaccine development and drug discovery." Scientists in the C. neoformans research community - including Heitman at Duke and Jennifer Lodge at Saint Louis University (SLU) School of Medicine say the project already has given impetus to bi...Research turning up the heat on fowl bacteria
...and Thompson hope their studies will help identify targets for better treatments for the disease and ultimately a vaccine to prevent it. In the meantime, they encourage consumers to cook poultry products thoroughly and carefully wash their hands, pots, utensils, counters and anything else that comes in conta...Study finds more than one-third of human genome regulated by RNA
...(Prior to this study, there were no known microRNA targets in any vertebrate.) In their latest paper, taking advantage of the most recent genome-sequencing data, the team has compared human genome data with that of the dog, chicken, mouse, and rat. For each of the microRNAs and protein-coding genes that are...EB and IUPS - Where cures of tomorrow can be seen in the science of today
...reprogramming of cancer cells; new pharmacological targets for Alzheimer's; pharmacogenetics, perception and reality; C-reactive protein as a possible therapeutic target for cardiovascular disease; genetic susceptibility to estrogen carcinogenesis; and long term effects on adolescents' developing brains of n...Combination therapy boosts effectiveness of telomere-directed cancer cell death
...effectiveness of a promising cancer treatment that targets telomeres in an attempt to interfere with the ability of a cancer cell to continuously divide. Telomeres are DNA sequences found at the ends of chromosomes that play a key role in controlling the life span of cells. With every cell division, telomere...