Tag: "targets" at biology news

In asthma, it's not the drugs but the inflammation that increases cardiovascular risk, damage

... induced by asthma and the appropriate therapeutic targets should provide better, specific alternatives for patients symptomatic for both asthma and cardiovascular disease, or CVD," Hazarika predicted. Study shows asthma "helps" heart attract damaging inflammatory cells The results of the studies indicate ...

Automated imaging screen reveals promising drug candidates

...sis have produced a growing list of potential drug targets - drowning drug researchers in an excess of riches. In the open-access journal PLoS Biology, Kevan Shokat and colleagues report a high-throughput screening method that substantially narrows the field of candidate therapeutic agents. Their approach ta...

Scientists find molecular pathway suspected in precancerous stomach lesions

... It should give us a list of potential therapeutic targets and could even help us to prevent the development of the precancerous lesions." The lead author is Byeong-Moo Kim, PhD, also of Dana-Farber. Patients with the increasingly common disorder known as Gastroesophageal Reflux Disease, or GERD, are at ri...

Researchers test new therapy for advanced melanoma

...exibility to introduce a huge variety of potential targets for treatment, but its major limitation has been getting the gene into the cancer. If electroporation can deliver the gene to these tumors reliably and without serious side effects, melanoma and other cancers would be open to many new treatment poss...

$3 million donation accelerates TGen breast cancer research

...search will likely identify molecules that will be targets for novel diagnostics and therapeutics in breast cancer, a goal in line with TGen's vision of personalized disease management. "Since the day it was conceived, TGen hoped to increase the speed in which genetic discovered were moved into the clinic," ...

Scientists making advances receive international awards

...signaling pathway abnormalities in cancer cells as targets for drug therapy, will give his lecture "Molecularly targeted cancer therapy: Future challenges," at noon on Tuesday, April 19, in Hall A of the Anaheim Convention Center. Napoleone Ferrara, M.D., Fellow at Genentech, Inc. in South San Francisco, CA,...

Alfred G. Knudson Jr., receives American Association for Cancer Research Lifetime Acheivement Award

...mor-suppressor genes, in particular, are important targets for prevention research, since they normally function to apply the brakes to cellular growth. Knudson received his B.S. from the California Institute of Technology, his M.D. from Columbia University, and his Ph.D. from the California Institute of Tec...

Protein tags regulate key ion channel

...cellular activity but until now its 60-or-so known targets were primarily nuclear proteins, mostly involved in gene transcription. "The findings expand the influence of SUMO-related activity in biology," Goldstein said, "a great and exciting surprise." There is still a good deal that we don't understand abou...

Lewis C. Cantley, Ph.D., receives Pezcoller-AACR International Award for Cancer Research

...elucidation of this network is revealing effective targets for pharmaceutical intervention in a wide variety of human cancers." A recipient of numerous awards, Cantley was elected to the American Academy of Arts and Sciences in 1999 and to the National Academy of Sciences in 2001. He serves as an associate e...

Remote control flies?: Fly behavior controlled by laser light

...ote controls placed in other nerve cells that were targets of the giant fiber system worked 82 percent of the time, the researchers concluded. Lima and Misenbck also equipped another set of nerve cells called dopaminergic neurons with the remote controls, boosting the flies' activity levels and changing thei...

International gathering of scientists looks toward future of cancer research

...eevec resistance; COX2/NSAIDs for chemoprevention; targets for diagnostics and therapies; predicting risk, treatment and outcome based on genetic variables; drug and supplements that lower risk; latest on diet and risk. Symposia and Forums: covering a diverse range of timely and central topics of critical i...

Microscopes at microscopic size

...rs to allow the scientists to analyse the cells or targets within the cells. Researchers can use this capability to examine cellular conditions for certain diseases or to develop new treatments by studying the way cells react to a drug. The biochips also raise the possibility of a micro-laboratory, the size ...

Research shows overfishing of sharks key factor in coral reef decline

...onger than expected because fishing preferentially targets species whose removal can destabilize the food web," the authors conclude in their report. Because of their comprehensive approach in developing the intricate food web, the authors say their study and its results address more than individual species ...

Cholesterol-regulating protein maintains fat-storage, fat-burning balance

...ern Medical Center study that may lead to new drug targets in the fight against obesity. In animals and humans, a protein called the liver X receptor, or LXR, senses cholesterol levels. When these receptors detect rising amounts of cholesterol, they activate genes and a series of biochemical reactions that ...

University of Pittsburgh gets wired for speed with Apple Xserve G5 cluster

...to the factors that contribute to diseases give us targets for effective therapy. The new Gattaca Cluster is a terrific tool to help the discovery process." Future plans exist to extend Gattaca's workload even more by analyzing data from microarrays and large SNP-chip studies, which can involve as many as 10...

JCI table of contents May 1, 2005

... of latent Epstein-Barr virus proteins as putative targets of an immune response in multiple sclerosis AUTHOR CONTACT: Bernhard Hemmer Heinrich Heine University, Duesseldorf, Germany Phone: 49-2118119296; Fax: 49-2118118485; E-mail: bernhard.hemmer@uni-duesseldorf.de View the PDF of this article at: http...

A kiss that binds

...translation in the brain, and identifying the mRNA targets of this regulation would be a huge step in underst...hese findings will redirect the search for the RNA targets of FMRP whose misregulation is responsible for the disease, to those containing kissing complex moti...

Study reveals candidate targets for anti-retroviral therapeutics

... virus, HIV, makes identification of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a potential source of such novel targets, but relatively few appropriate target genes have been identified in animal cells thus far. A new study, conducted by Dr. Suzann...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...tiple-drug resistance and illuminate potential new targets for overcoming this cause of treatment failure in childhood ALL," explains Dr. Evans....

Study reveals dramatic difference between breast cancers in US and Africa

... the breast and often do not present the molecular targets that form the basis of many standard therapies. "We have known for a long time that breast cancer is not one disease and that it may be somehow different in Africa," said study author Funmi Olopade, M.D., professor of medicine and director of the Cen...

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(Date:10/14/2014)... millions of years since T. rex took ... University scientists is breathing life back into dinosaurs using ... The research has important implications for how dinosaurs used ... the sense of smell and cool their brains. ... doctoral student Jason Bourke, lead author of the new ...
(Date:10/14/2014)... a new kind of stem cell that can become either ... vessels, according to a study published today in the journal ... cell type contradicts current theory on how organs arise from ... origins of, and future treatment for, liver cancer., Thanks to ... complex being made up of more than 200 cell types. ...
(Date:10/14/2014)... led by researchers at the University of Massachusetts ... Miller School of Medicine (UMMSM) have identified what ... (manic depressive) disorder, a breakthrough that could lead ... as well as depression and other related mood ... week in Nature Molecular Psychiatry , show ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
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