Tag: "targets" at biology news

Combination of Lipitor and Celecoxib

...The non-steroidal anti-inflammatory drug celecoxib targets the COX-2 inflammation pathway and has been shown both in experimental animal studies and in human trials to reduce the incidence and progression of colon cancer. Lipitor, a statin drug aimed at lowering cholesterol and used in humans primarily in ...

Readers of genome decipher signatures of cancer patient outcomes

...mponents of these pathways would become attractive targets for development of novel, target-tailored individu...h information may be used to suggest new treatment targets specific to this form of skin cancer. "In cutaneous melanomas, no active adjuvant therapy has been f...

Turning viruses into allies against cancer

... this receptor thus makes liver cancer cells ideal targets for the measles virus. The results confirmed widespread infectivity, toxicity and destruction among these cells, probably through apoptosis or programmed cell death. When the modified virus was injected directly into human liver cancer cells grafted ...

Cerebral navigation: How do nerve fibers know what direction to grow in?

...cues affect the growth cone, and identify possible targets within axons that could be blocked to overcome this inhibition. Such intervention could possibly enable damaged axons to regenerate (normally impossible in a mature nervous system) and ultimately restore nerve function. It's been known that cells sy...

Overworked brains release adenosine to slow cells, trigger sleep, UT Southwestern researchers find

...body's natural sleep process, as well as potential targets for future treatments for insomnia and other sleep problems. Prolonged increased neural activity in the brain's arousal centers triggers the release of adenosine, which in turn slows down neural activity in the arousal center areas. Because the arous...

A puzzle piece found in unraveling the wiring of the brain

...red for nerve cells to make appropriate choices of targets on which to act. The Sec15 protein is part of a protein complex (the exocyst) which is known to be required for secretion (or exocytosis) of vesicular compartments in yeast. Vesicular compartments are small organelles that transport proteins from on...

New drug may be used to treat women with ovarian cancer

...ycin, a drug used as an immunosuppressant. RAD001 targets an enzyme known as mTOR (mammalian target of rapamycin). In mice injected with human ovarian cancer cells with high AKT activity, the researchers found that RAD001 arrested the cells so they couldn't divide (reproduce) or move to another location in...

How safety feels good

...ates of these mechanisms are likely to provide new targets for the treatment of a variety of psychiatric disorders involving anxiety, mania, anhedonia, and addiction, and a greater understanding of highly adaptive psychological characteristics such as resilience."...

Green tea shown to prevent prostate cancer

.... Bettuzzi and his colleagues had found that EGCG targets prostate cancer cells specifically for death, without damaging the benign controls. They identified Clusterin, the most important gene involved in apoptosis, or programmed cell death in the prostate, as a possible mediator of catechins action. "EGC...

A decade after launch, ERS-2's mission continues

...valuable for the analysis and monitoring of stable targets in urban areas." ERS-based InSAR is increasingly being employed in this way for urban risk assessment. Some 200 European and Mediterranean towns are being surveyed as part of the initial activities for Global Monitoring for Environment and Security ...

Important brain finding results from boy's rare, fatal disease

...mily can contribute to advances in medicine." VWM targets cells that make up part of the brain's white matter, turning the normally strong and durable substance into a yellowish, gelatin-like material. While we hear a great deal about the importance of our "gray matter," a term that refers to crucial brain ...

ASU researcher creates novel 'bioelectronic signatures' to detect DNA mutations

... also is readily adaptable for identifying protein targets or single virus molecules, which is what makes it suitable for diagnosing genetic diseases, detecting infectious agents and providing reliable forensic analysis. In addition, the technology is scalable for the so-called "high throughput," or large-sc...

Scientists find microRNAs regulate plant development

...RNAs, and therefore have been considered potential targets of microRNA-mediated regulation. One of these targets is the transcription factor AUXIN RESPONSE FACTOR17 (ARF17), which is thought to repress the express...

Rutgers' Tabasco Sauce connection

...ing in concert. Multiple agents attacking multiple targets simultaneously present decided advantages over conventional drugs which are each based on one compound that produces one action, Raskin explained. "When you have a complex condition like metabolic syndrome in which so many things can go wrong, it wil...

Scripps research scientists identify infertility molecule

...echanisms involving these proteins might make good targets for therapeutic intervention, perhaps even leading...or molecule in the body, and an important class of targets for the design of drugs. Indeed, about half of the medicines on the market target such GPCRs. ...

Genome of social amoeba shows its importance as research model

...makes Dictyostelium a better model for looking for targets against which drugs can act....

Story tips from the Department of Energy's Oak Ridge National Laboratory, May 2005

...e thermodynamics of the process to meet efficiency targets and study the fuel impacts of eventual commercialization of the technology. The higher engine efficiency obtained through this technology would help toward meeting the engine efficiency goals for prototype truck engines scheduled for 2012 in the 21st...

Biologists determine genetic blueprint of social amoeba

...makes Dictyostelium a better model for looking for targets against which drugs can act." Key collaborators in the project at Baylor included Richard Gibbs and George Weinstock, co-directors of Baylor's Human Genome Sequencing Center, and Richard Sucgang, an assistant professor of biochemistry. Baylor perform...

Brain chemical serotonin involved in early embryo patterning, Forsyth scientists find

...ing, would suggest numerous new roles and possible targets for serotonin-related drugs like the selective serotonin reuptake inhibitors (SSRI antidepressants such as Prozac and Zoloft) or the monoamine oxidase inhibitors (MAOIs). Could lead to a greater understanding of potential health risks from drug fam...

Scripps scientists describe protein used by bacteria and cancer cells to resist drugs

... undergoing small point mutations in the molecular targets that lower a drug's affinity, and overproducing a drug's substrate in the cell. However, another way that bacteria resist antibiotic drugs is by using membrane transporters -- large proteins that sit in the cell membrane and move other molecules in...

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(Date:10/29/2014)... consequence of chemotherapy will benefit from a major research ... prevents hair loss. , The research is being now ... manufacturing company, Paxman Coolers, of Fenay Bridge, Huddersfield, in ... Huddersfield. , The research will be led by key ... pharmacology of cancer treatment, which he will use towards ...
(Date:10/29/2014)... but they also need protection from its harmful rays, just ... in plants that shields them from sun damage. Now, in ... Society , one team reports on the mechanics of how ... at Purdue University note that the harsh ultraviolet radiation plants ... DNA and, as a result, hinder plant growth. Biochemical ...
(Date:10/29/2014)... German . ... Peter Schlögelhofer at the Max F. Perutz Laboratories (MFPL) ... of Vienna dived into the process of meiosis in ... an inversion of the standard meiotic phases. The researchers ... Nature Communications . , Meiosis is the two-step series ...
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