Tag: "targets" at biology news
JCI table of contents June 1, 2005
...est that BMP signaling pathways may be therapeutic targets
for ameliorating spondyloarthropathies. TITLE: Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis AUTHOR CONTACT: Frank P. Luyten Katholieke Universiteit Leuven, Leuven, BEL Phone: 32-16-34...
Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
...n functions (fixed growth rules) and fixed harvest targets
is no longer supportable," says Sugihara. "The beg... adaptive management strategies. Fisheries harvest targets
need to be flexible and precautionary. This result strengthens the scientific basis for these polic...
Building a human kinase gene repository
...of pathological conditions, which make kinases key targets
in drug discovery efforts, primarily in oncology. This collection is unique because clones in the collection represent protein kinases as well as non-protein kinases, are fully sequenced verified, full-length, and can be sub-cloned by recombination b...
The lopsided brain: Attention bias is shared by humans and birds
...re asked to "cancel-out" evenly distributed visual targets
on a sheet of paper placed before them. The finding that birds also exhibit spatial pseudoneglect is somewhat surprising, given that birds lack a corpus collosum, the structure in human brains that is thought to facilitate rapid communication between...
Protein prevents detrimental immune effects of bacterial sepsis
...e pathways: "The ultimate goal is to use these new targets
(e.g., a receptor for a given anti-inflammatory mediator) to develop better and safer drugs." The data for annexin 1 provide a new direction for such therapeutics that delicately balances removal of bacterial toxins and damage to host tissues....
Protein helps regulate the genes of embryonic stem cells
...rse biological processes. "It may give us new gene targets
to study relative to cancer and other disease states that may have these marks and have not been examined but should be," Magnuson said. Another application of epigenetics is stem cell therapeutics, in which any specific tissue type could be derived ...
Cure for common cold will need to wiggle to work, scientists say
... help cancer patients by identifying new molecular targets
and designing future agents and drugs for effectively detecting and treating cancer....
New understanding of DNA repair may pave way to cancer treatments
... May 27th edition of Molecular Cell, points to new targets
for treatment of cancer. Ze'ev Ronai, Ph.D., Director of the Institute's Signal Transduction Program, and his colleagues found that the protein ATF2 ("Activating Transcription Factor-2") is activated by a protein kinase called ATM ("Ataxia-Telangiec...
Dartmouth Medical School researchers identify enzymatic activity of neurological disease gene
...ccording to Dr. Seidle, is to identify the protein targets
MSKCC researchers uncover structure of key protein complex in cells
...E3 is a kind of chemical marriage broker, bringing targets
close enough to SUMO to facilitate binding. "E3 a... roles of sumoylation may well provide us with new targets
to inhibit the protein and therapeutic agents for cancer and other conditions in which SUMO is invol...
JCI table of contents July 1, 2005
EDITORS' PICK Vaccine targets
tumors where they live Vaccine strategies are being designed to battle cancer, but their use for metastatic melanoma is a challenge. Effective vaccines against established tumors require tumor-reactive T cells to traffic to the sites of the tumors...
Virus uses tiny RNA to evade the immune system
...us from spreading. Conveniently, the microRNA that targets
T antigen is made late in the infectious cycle, just when T antigen is no longer essential for virus replication. Further experiments showed that cytotoxic immune cells were more likely to kill cells infected with a mutant virus that cannot make the ...
Researchers report breakthrough against world's deadliest viruses
... both Ebola and Marburg. "In addition, the vaccine targets
dendritic cells, which are the same cells that Ebola and Marburg attack," said Dr. Geisbert. "These cells are also important in generating a protective immune response. So the vaccine goes exactly where we want it to go." The study describes how Cana...
Cancer research finds targets for new cholesterol-lowering therapies
...CR) and Harvard Medical School has uncovered novel targets
for the development of drugs that would potentially complement, or replace, statins in treating heart disease. Statins are commonly taken drugs that reduce the levels of low density lipoprotein (LDL) and have been shown to reduce risks associated wit...
NHGRI selects 13 new targets for large-scale sequencing program
...ision of Extramural Research. The first group of targets
consists of nine mammals. Eight mammals will be se...er date. NHGRI's process for selecting sequencing targets
begins with two working groups comprised of experts from across the research community. Each of the ...
Once given 'no respect,' cells' tiny RNAS take driver's seat
...bute to or help prevent cancer -- depends on their targets
in the cell," adds Myc specialist Chi Dang, M.D., Ph.D., the Johns Hopkins Family Professor in Oncology Research and a professor of medicine in the McKusick-Nathans Institute and the Johns Hopkins Kimmel Cancer Center. "Slowing E2F1 production would ...
Discovery offers promising lead in prostate cancer diagnosis
...ate cancer cells and could provide novel molecular targets
for diagnosis, prognosis or therapy of prostate cancer in the future. The report by Dr. Gyorgy Petrovics et al showing ERG expression alterations in a large fraction of prostate cancer cells is published in the latest issue (May 26, 2005) of leading ...
MicroRNA tweaks protein that controls early heart development
...esearchers discovered that a microRNA called miR-1 targets
the mRNA of the gene Hand2, a key regulator of hea... in vertebrates there are only three or four known targets
for those hundreds. "We are learning that microRNAs are a common mechanism through which a cell reg...
NIH creates nationwide network of molecular libraries screening centers
... disease, which is key to identifying possible new targets
for diagnosis, treatment and prevention. To date, ...sease, and even to the identification of potential targets
for new therapies. Central to this effort are the databases supporting the network, which will allow...
Columbia University launches multi-year campaign to support stem cell research
...ion of disease. Stem cells will also be useful as targets
in drug discovery. Current stem cell research projects at CUMC include: Examining the development, function and survival of dopamine neurons, which are lost in patients with Parkinson's disease, focusing on developing replacement cells or a model ...
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