New DNA repair enzyme makes mistakes to save lives of cells
...source determines which enzyme is involved and its technique for repair. For instance, normal wear and tear on a cell can cause a base to break off the DNA strand, and enzymes, including POL-Q, repair the DNA by inserting bases where they are found missing. POL-Q also repairs bases that are damaged or chemical...New genomic method can identify disease-causing genes
...ors accurately for a wide range of trait data. The technique also has the potential to uncover currently unknown genetic factors contributing to a host of different diseases. Roche scientists first published a computational method for mouse genome analysis in the June 8, 2001 issue of Science. That metho...Mouse study: 'Critical' Down syndrome region isn't
...key players." As part of this effort, Olson used a technique to precisely duplicate a defined chromosome segment and applied it to the DSCR section on mouse chromosome 16, the analog of human chromosome 21. She also made a mouse chromosome 16 that lacked DSCR entirely. Then scientists in Hopkins' Transgenic M...New method studies living bacterial cells
...work also pioneers a potentially revolutionary new technique for investigating microbiological systems in natur... interactions in contaminated environments. "This technique also should be directly applicable to investigations of microbial processes in extreme subsurface en......esses the sensation of sound. MEG is a noninvasive technique that is highly sensitive to the brain's response to sounds. This work is among very few MEG studies carried out with autistic children. The researchers measured a brain response called the M100, a neuromagnetic signal that reflects the corte...Singled out: Spotting mutant neurons in normal brains offers clues to Fragile X
...del of the disease, the researchers utilized a new technique that allows the generation of single mutant nerve cells that are marked by their expression of a glowing fluorescent protein, making these nerve cells distinctly visible in an otherwise normal brain. In their experiments, the researchers were able to...Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...l expects this to increase to 20 percent. Once the technique is fully refined, the next step would be clinical trials in humans. Another major area of research in Kunkel's lab involves genes that influence lifespan. Kunkel's work led to the identification of a single gene on chromosome 4 that gives people an ...Stimulating nerve cells with laser precision
...thout actually touching the nerve cells. "This technique brings nerve stimulation out of the Dark Ages," sa...to make electric nerve stimulation better, but the technique is inherently limited. Using lasers instead, we can simultaneously excite and record the responses o...Mail-order drugs exposed to extreme heat become less effective
... dispensed into a filter tube using the inhalation technique and device provided by the manufacturer. Weights of the filter tube pre- and postdispensation were obtained to calculate simulated drug delivery. Results showed that filter weights of heated medications were less than half of those unexposed to hea...Trojan-horse therapy blocks buildup of Alzheimer's plaque
...the brain-clogging protein. The new "Trojan horse" technique overcomes a major challenge in drug design namely...ef's insight, said Crabtree, that the Trojan horse technique might be ideal to prevent the formation of toxic amyloid aggregates to prevent Alzheimer's disease. ...Scientists closing in on nerve proteins' contributions to memory and hearing loss
...A and change the activity levels of genes. Using a technique known as an electrophoretic mobility assay study, scientists tested Ngr-ICD's ability to bind to parts of various zinc-finger proteins that they already knew could increase the activity of PSD-95. After this study and additional testing, they determi...Hurricane Ivan helps student study sinkholes
...l, Va., in Highland County, is using an innovative technique to characterize ground water movement in sinkholes...s happening underground. He is using a geophysical technique called electrical resistivity. Current is passed through the soil using a car battery attached to tw...Economics and ecology combine at UGA in NSF-funded study of evolutionary game theory
...enan, before adding a final note that the solution technique being applied is the Nash equilibrium, the creation of Nobel Laureate John Nash, who was depicted in the movie, "A Beautiful Mind."...Researchers grow sperm stem cells in laboratory cultures
...animal indefinitely. (The researchers developed a technique for successfully freezing and thawing spermatogoni...ing their fertility. Moreover, the new culture technique would allow researchers to further investigate the potential of spermatogonial stem cells as a sourc...Crucial evolutionary link points to origins of modern cells
...ze what the NPC looks like, through a mathematical technique Sali pioneered called homology modeling. Because t...mbination of Sali's mathematical homology modeling technique and biochemical analyses, the scientists -- led by first author Damien Davos, Ph.D., and Svetlana Do...Powerful 'toolkit' developed for functional profiling of yeast genes
...issing." The researchers dubbed the combined technique dSLAM, for diploid-based synthetic lethality analy...c Medicine at Johns Hopkins, revealed that the new technique missed fewer of the known gene interactions and provided more consistent results than older techniqu...A new target for control of obesity
...ain by using a highly advanced genetic engineering technique called "cell-type specific gene knockout". The progeny were mice with early-onset obesity that had increased levels of leptin, insulin, glucose, and triglycerides. Furthermore, the mice could gain weight by eating normal amounts of food, which supp...St. Jude named 'Research Leader' by Scientific American magazine
...ology category for his work in reverse genetics--a technique for custom-making influenza vaccines in as little as 14 days. For more than 50 years, flu vaccine has been produced by growing the virus in fertilized chicken eggs, a process that takes at least six months. Reverse genetics may one day revolutionize ...Identifying the path to infection
...ge individual proteins in the crystal, they used a technique called cryo-electron microscopy. In this method, the crystal is cooled to about minus 300 degrees Fahrenheit using liquid nitrogen and placed in an electron microscope. This device bombards the sample with high-energy electrons, which scatter off the...UO study is first to link histamine receptors to heat stress
...onally don't like needles but it's a very powerful technique to study skin blood flow," says Wong, who knows fi...at the subjects will experience, having tested the technique on himself. A water-perfused suit is designed to tightly control skin temperature. The subject...