Decreased TGF-beta signaling might make you demented
... Tony Wyss-Coray an...A crucial role for TGFbeta signaling in congenital eye disorders
The lens in the developing eye acts as a TGFbeta signaling center that controls differentiation, survival and formation of multiple eye structures deriving from the neural crest. A study published today in the open access journal Journal of Biology shows that neural crest (NC) derived cells contribute to both anterior and posterior parts of the developing mammalian eye. NC cells migrate properly...