Abnormal fat metabolism underlies heart problems in diabetic patients
... In addition, these findings suggest potential new therapeutic approaches." Even though the research team found a depletion of an important type of lipid in diabetic heart tissue, diabetic heart muscle cells actually take in excess lipids. But as these lipids enter cells they activate lipid-digesting enzymes. I...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...e as well as monitor the biological effects of new therapeutic agents. Chad Antony Dickey, Ph.D., Assistant P...epresent an entirely novel class of candidates for therapeutic development in Alzheimers research. Isabella A. Graef, M.D., Assistant Professor, Stanford Unive...Research shows skeleton to be endocrine organ
...his discovery potentially opens the door for novel therapeutic avenues for the prevention and treatment of type 2 diabetes. The discovery that our bones are responsible for regulating blood sugar in ways that were not known before completely changes our understanding of the function of the skeleton and uncover...New molecular regulators of hyperthyroidism and goiter
...ivated downstream of these G proteins, might be of therapeutic benefit for individuals with diseases characterized by increased thyroid gland function and/or growth....JCI table of contents: Aug. 9, 2007
...ivated downstream of these G proteins, might be of therapeutic benefit for individuals with diseases characterized by increased thyroid gland function and/or growth. TITLE: Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development AUTHOR CONTACT: Stefan Offermanns Universi...Study finds gender differences in renal and other genes contributing to blood pressure
...ply that the development of genetic diagnostic and therapeutic indices for hypertension must take gender into account to provide an accurate assessment and treatment of hypertension. ...Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
...velopment of obesity and hypertension, opening new therapeutic approaches to postmenopausal hypertension. ...Other highlights in the Aug. 7 JNCI
...the epigenome. These results may have important therapeutic implications. Because of their potential reversibility, epigenetic modifications are under investigation as potential targets for the treatment of various common cancers, the authors write. Contact: Nick Zagorski, nzagors1@jhmi.edu , (443) 287-2...Penn researchers discover how key protein stops inflammation
...ope to create new ways to control inflammation for therapeutic purposes with selective anti-inflammatory agents, says Carmody. Although drugs to suppress inflammation currently exist, Chen and Carmody say they cause many undesirable side effects in patients with inflammatory diseases. Current drug treatmen...UF, French scientists seek test to detect gene doping in athletes
...s commonly used to deliver genes into the body for therapeutic purposes. Gene doping would enter the body through...rocedures are as different as night and day from a therapeutic standpoint. When you use the phrase gene therapy it should be very clear that youre talking abou...Unlocking proteins from their cellular shell
...f protein phosphorylation and cell activation, new therapeutic strategies are bound to emerge....New strategy for treating allergic disorders
...nce again. They introduced DNA with the code for a therapeutic protein into the bacteriums DNA. Together with Inge L. Huibregtse, a physician at the AMC, the VIB researchers succeeded in having L. lactis produce the ovalbumin (OVA) protein. Tested on mice Inge L. Huibregtse (AMC) and Veerle Snoeck (VIB) eval...Altering a protein makes mice less fearful
...iety disorders and may even point the way to a new therapeutic target. For humans and other animals, some fears seem to be, in large part, instinctive and inborn rather than learned. For example, laboratory animals fear certain predators even though they have never been exposed to a predator. However, little i...Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
PHILADELPHIA A therapeutic cancer vaccine has shown effectiveness when given ...us vaccine to prevent cervical cancer, TroVax is a therapeutic vaccine, designed to stimulate the immune systems of patients who already have cancer. The vaccine c...Forsyth scientists gain new understanding of adult stem cell regulation
...havior and may help medical science identify novel therapeutic targets. The Forsyth team previously found that communication through gap-junctions (microscopic tunnels directly linking neighboring cells) controls the left-right asymmetric positioning of the internal organs during embryonic development. In thi...Under magnetic force, nanoparticles may deliver gene therapy
... arterial muscle cells, where the DNA could have a therapeutic effect. Although the research, done in cell cultures, is in early stages, it may represent a new method for delivering gene therapy to benefit blood vessels damaged by arterial disease. The nanoparticles are extremely small, ranging from 185 to 375...New UD tissue-engineering research focuses on vocal cords
...ction of vocal-fold scarring remains a significant therapeutic challenge, Jia said. Jia and her colleagues want to explore two parallel tissue-engineering approaches to regenerate the lamina propria. One method focuses on injecting gelatin-like materials, composed of soft, strong and long-lasting hydrogels, in...Research shows NPD1 protects a key component of vision
...nificant because they may allow the exploration of therapeutic interventions for retinal degenerative diseases such retinitis pigmentosa. ...After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
...e biology of the disease, and could be targets for therapeutic development." Both studies searched for a link b...but that protein is already being viewed as useful therapeutic target. In a 2004 study by NINDS scientists, 10 MS patients who were unresponsive to currently appr...