Tag: "therapies" at biology news

Study begins to reveal clues to the cause and progression of sepsis

...ased on data from small studies, and most of these therapies have failed. Researchers at the University of P... would suggest, and far longer than the courses of therapies used in unsuccessful clinical trials of experimental agents, said John A. Kellum, M.D., professor, d...

Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma

...dies may lead to the development of more effective therapies for individuals with multiple myeloma (MM), a common and incurable blood cell cancer. The research, published by Cell Press in the August issue of the journal Cancer Cell, provides new insight into the molecular mechanisms that underlie aberrant NF-&...

Invasion of the brain tumors

...rom the primary tumor site, rendering conventional therapies ineffective and leading to an invariably poor prognosis. In a new study published online this week in the open-access journal PLoS Biology, Angela Johnston, Donna Senger, and colleagues at the University of Calgary injected immunocompromised mice wit...

Doernbecher Children's Hospital scientist earns coveted Javits award

...the help of this long-term grant, wehope to devise therapies that cannot only reverse brain damage ininfants bu... says,because of the lack of animal models to test therapies for the complexforms of brain injury that occur in human survivors of premature birth.Recently, Back...

Abnormal fat metabolism underlies heart problems in diabetic patients

...severity of heart disease and to evaluate how well therapies work. In addition, these findings suggest potential new therapeutic approaches." Even though the research team found a depletion of an important type of lipid in diabetic heart tissue, diabetic heart muscle cells actually take in excess lipids. But ...

OHSU turns mouse into factory for human liver cells

... it also can be used as a platform for testing new therapies against infectious diseases that attack the liver, such as hepatitis C and malaria. "This has the potential, if it becomes easy to use and widely available, to change the way drugs are tested," said study leader Markus Grompe, M.D., professor of mo...

Genetic variation helps to understand predisposition to schizophrenia

...rlying biology of the disease and develop improved therapies based on peoples genes, Law says. The insight gained on the Neuregulin 1 gene is, I hope, bringing us closer to that goal....

Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease

...d beta as a biomarker of Alzheimer's disease" New therapies for AD are hindered by the lack of reliable biomarkers which could track the clinical progression of the disease. Dr. Boutauds research seeks to quantify whether levels of secreted APP alpha and beta could serve as an effective biomarker for Alzheim...

High-intensity ultrasound may launch attack on cancer, wherever it lurks

...tment could be an important advance in many cancer therapies because of its potential to tackle both primary tumors and metastatic cancers that have spread to other organs -- all without the need for surgery, the research team reported in the Journal of Translational Medicine on Aug. 3 (a provisional version a...

Penn researchers discover how key protein stops inflammation

...ce, open new avenues of exploration for developing therapies to treat infectious or inflammatory diseases, such as sepsis, diabetes, and rheumatoid arthritis. The novelty of our study is the discovery that Bcl-3 acting on gene expression has a profound effect on inflammation, says Ruaidhri Carmody, PhD, Sen...

Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells

... The findings may point researchers to future gene therapies for patients with sickle cell anemia and beta-thalassemia. In an article pre-published online Aug. 3 as a First Edition Paper in the journal Blood, the journal of the American Association for Hematology, researchers reported that a protein called ...

UF, French scientists seek test to detect gene doping in athletes

...in 2004, when the first reports of muscle-boosting therapies in mice were published by University of Pennsylvan... a wider purpose, and thats to understand how gene therapies are disseminated throughout the body, added Snyder, whose research stemmed from a cooperative agreem...

Defects in critical gene lead to accelerated lung tumor growth

...s gene is important for lung cancer and to develop therapies targeted in a way that can help human patients. To determine whether the model mirrors the genetic events of human lung cancer, the researchers analyzed DNA from 144 non-small cell lung cancer patients treated at UNC and affiliated hospitals. Defec...

Unlocking proteins from their cellular shell

... of cytoskeletal proteins that are targets of gene therapies and also on clarifying signaling processes in cells that couple to protein folding. The latter processes often entail modification of proteins with phosphates and are essential to how individual cells feel the forces exerted on them. Through a bett...

Altering a protein makes mice less fearful

...n theory, sets the stage for investigating whether therapies that block these ion channels in humans might be effective in anxiety disorders," said Wemmie, who also is a physician and researcher at the Veterans Affairs (VA) Iowa City Health Care System. The UI team found that ASIC1a is concentrated in brain ...

U-M researchers find family of 'on switches' that cause prostate cancer

...s. But long-term, we hope this will lead to better therapies to treat prostate cancer. The key challenge is to ...in donations to support work related to developing therapies against prostate cancer gene fusions at the university. Mapping of the human genome was only the b...

Scientists move closer to bio-engineered bladders

...ld soon be able to use the research models to test therapies for the bladder, but the longer term aim for this research is to help patients who have lost bladder function or have had all or part of their bladder removed because of cancer. Research leader, Professor Jenny Southgate, explains: "The models we ...

Stem cell therapy rescues motor neurons in ALS model

... study that demonstrates the promise of cell-based therapies for diseases that have proved intractable to modern medicine, a team of scientists from the University of Wisconsin-Madison has shown it is possible to rescue the dying neurons characteristic of amyotrophic lateral sclerosis (ALS), a fatal neuromuscu...

American Chemical Society's Weekly PressPac -- July 25, 2007

...owever, many barriers hinder efforts to move those therapies from lab to clinic. The use of small molecules compounds that include most drugs to generate new nerve cells from easily available cells or tissues would provide a more convenient and attractive approach to stem cell therapies, the new study notes....

Uncovering the secrets of the deep

...l events have been the basis and source of medical therapies and industrially important processes. Analysing the genomes of diverse and novel species continues this adaptation of biological innovation for beneficial application....

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(Date:10/17/2014)... – Accurate knowledge regarding Ebola is critical and pertinent ... of hazardous global outbreak and epidemic. The Journal, ... a special issue, Ebola Virus and Public Health, to ... knowledge in this critical societal moment. , On ... Ebola for Clinicians . The primer was prepared by ...
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