First new multiple sclerosis gene found in 30 years
...y hold the promise of guiding future research into therapies for multiple sclerosis in what its discoverers say is the first major genetic advance in 30 years for understanding this nervous system disease. While it has been known that there is a strong genetic underpinning for multiple sclerosis, only genes ...After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
...tients who were unresponsive to currently approved therapies showed improvement when treated with an antibody that blocks IL2R-alpha, developed to prevent rejection of organ transplants. Finally, the genome-wide scan identified nearly a dozen other genes that could represent risk factors for MS. Some of the...Prenatal stress keeps infants, toddlers up at night, study says
...al treatment, OConnor said. Several evidence-based therapies exist, and unlike medication, none of them are suspect in the least for causing adverse effects to baby. Given prenatally, psychological interventions could instill a whole host of benefits that may carry-over to the child, OConnor said. Still, mor...Boston Univeristy bioengineers devise 'dimmer swith' to regulate gene expression in mammal cells
... in the coming decades well increasingly see these therapies being introduced as part of routine medical practice....Scratch no more: Gene for itch sensation discovered
...disease. It can be a serious side effect of cancer therapies or powerful painkillers like morphine. For some people, chronic itching can be very disruptive, interfering with sleep or giving rise to scratching that leads to scarring. Effective treatment options for itchy patients are limited. Historically, scie...Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
...ng rats. This indicates that the success of these therapies on humans could also be evaluated using MRI techno...ted or repaired with a combination of conventional therapies at the time of injury, according to Kalderon....Contributing membership in the biomarkers consortium surges to 30 companies and nonprofits
...ccelerate delivery of technologies, medicines, and therapies for successful prevention, early detection, diagnosis, and treatment of disease. The identification of biomarkers is an essential element for the new era of predictive, preventive, and personalized medicine in which the accuracy of individual health...First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
... examination of genomes could lead to improved HIV therapies and provides new targets for vaccine developers, s...ltogether--they might be able to rationally design therapies or vaccines to mimic these naturally occurring genetic advantages, he notes. In 2006, CHAVI resea...Immune system 'escape hatch' gives cancer cells traction
...sible, raising the possibility of vaccine and drug therapies that break through the blocked immune system. Previous research had confirmed that MDSCs, produced in the bone marrow, were attracted to tumors, but until now, scientists had not identified exactly how the cells inhibit the immune systems abilit...Gene discovered for type 1 diabetes in children
...ntervene early in life with targeted drugs or cell therapies to prevent the disease from developing, said Polychronakos. The current research used a technique called genome-wide association, in which highly automated analytic equipment rapidly scans each patients DNA for more than half a million genetic mar...Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
...nt pathological studies of response to neoadjuvant therapies has been on the primary tumour rather than nodal s... years. However, the evidence for which additional therapies work best is confusing and conflicting. What is more, although it is widely accepted that there is a...JCI table of contents: July 12, 2007
... may be critical targets valuable to the design of therapies for autoimmune diseases such as MS. TITLE: A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE AUTHOR CONTACT: Eli E. Sercarz Torrey Pines Institute for Molecular Studies, San Diego, California, U...Antibody retards growth and induces death in liver cancer cells
...the first targeted therapy for liver cancer. Other therapies have some modest benefits, but no one knows exactly how they work. We now have identified a pathway that appears to be overly active in more than 70 percent of the cancers we examined and, when targeted, leads to significant reduction in tumor cell p...Global community listens to TAU genetic researcher at EU Conference on Hearing Loss
...ay and in the future for developing treatments and therapies to prevent further loss. One day a cure may be within reach, says Prof. Avraham, stressing the importance of international academic collaboration to achieve further breakthroughs. European figures for hearing impairment mirror those in the U.S. Ov...New gene mutation identified in common type of dementia
...s disease works and eventually help us develop new therapies for the disease, said study author Amalia Bruni, MD, of the Regional Neurogenetic Centre in Lamezia Terme, Italy. The researchers discovered a new mutation in the gene named progranulin in an extended family in southern Italy. The genealogy of thi...University of Cincinnati receives $1.7M to research molecular treatment of brain injury
...e Mayfield Neurotrauma Research Lab, is to develop therapies for traumatic brain injury, a condition for which there is no effective medical treatment. When the brain suffers traumatic injury, Strauss explains, it automatically takes self-protective action. The brain cells release arachidonic acid, which tr...New 'asthma gene' could lead to new therapies
...ic Health. "I think eventually it will lead to new therapies because it points to a specific biological molecular pathway. Once we understand the biology and we know the players, it's possible to target with specific drugs." Childhood asthma treatments are heavily focused on allergic responses, since most ch...Complementary therapy for infertile women may reduce chances of pregnancy
Complementary therapies in assisted reproduction may diminish the effectiv...h had also shown that women who used complementary therapies were more negatively affected by their fertility problems than non-users, and that this could accoun...Researchers identify genetic mutation that may alter tumor cell proliferation
...in cancer cells to successfully develop innovative therapies has been validated with oncology drugs such as Gleevec in leukemia and Herceptin in breast cancer....From clinical cancer research: rethinking therapeutic cancer vaccine trials
...T) experimental standards works well in evaluating therapies that are toxic to tumors, such as radiation or che...s exam-ples of ongoing progress in similar vaccine therapies for lymphoma, melanoma, pancreatic, lung and other types of cancer....