Waging war on the deadliest superbug
...cause the disease and can begin the search for new therapies to prevent or cure it. Professor Minton said: Although we have the entire genetic blueprint of C.diff, and have an inkling as to what bacterial factors might be important in disease, we have been unable to test these ideas. You never really know ...Researchers discover method for identifying how cancer evades the immune system
...mor to defeat the immune system, then we can apply therapies that compensate for these genetic alterations. According to Epstein, tumors are notorious for demonstrating a broad array of genetic and biological variations. Their differences vary widely between cancer types, even between subcategories within a ...New approach to pulmonary hypertension shows promise
...sion, making the treatment difficult. Most current therapies are designed to attack one abnormality at a time, Michelakis said, adding that this work shows for the first time that several of these abnormalities, so far considered to be unrelated to each other, may in fact be the result of a single problemactiv...New approaches to endometriosis treatment -- mouse experiments point the way
...ce, she says. This is encouraging, since current therapies are still associated with a high recurrence rate, and many of them can only be used for a limited time due to unacceptable side effects and/or osteoporosis. For women with pain, surgery can provide a temporary relief, although symptoms recur in up ...Cell receptor may lead to new 'biomarker' for pancreatic cancer
...give drug developers a new target for RON-directed therapies that are more effective in treating this deadly disease. When cells became invasive, Waltz said, we saw higher levels of RON expression that correlated with the aggressive nature of this disease and cancer metastasis. Clearly, this signaling pathwa...New genetic test developed at Emory advances detection and diagnosis of muscular dystrophy
...ical data. "Our new genetic test, along with new therapies currently in clinical trials, is a very positive development for muscular dystrophy patients and their families," says Dr. Hegde. In the last five years DMD research has accelerated, resulting in more knowledge about the role of the dystrophin gene...Early environmental exposure may accelerate age-related neurodegeneration
...and paraquat as important in PD, and suggests that therapies that block their effects would be worth testing in patients, says Marie-Francoise Chesselet, MD, PhD, of UCLA, who did not participate in the study. Ten-day-old mice were fed iron for a week. At ages from two months to two years, they were then exp...Story ideas from Molecular & Cellular Proteomics
...tific community, could help develop more effective therapies against coronary heart disease. The investigators ...es. These new findings should help improve current therapies against colorectal cancer, especially for patients with tumors producing clusterin, the scientists c...Cord blood may preserve insulin levels in children with type 1 diabetes
...iseases did not markedly improve until combination therapies were administered. I suspect it will be the same with diabetes. The Juvenile Diabetes Research Foundation and the National Institutes of Health funded the study, with support from UFs Clinical Research Center. UF researchers next plan to enroll up ...American Chemical Society's Weekly PressPac -- June 20, 2007
...sults may aid future development of more effective therapies for aspirin-resistant patients, the study concludes. ARTICLE #1 FOR IMMEDIATE RELEASE Relationship between Vitamin D Binding Protein and Aspirin Resistance in Coronary Ischemic Patients: A Proteomic Study DOWNLOAD PDF http://pubs.acs.org/cgi-bi...Nanotechnology, medicine and bioethics
...regenerative powers that could potentially lead to therapies for conditions such as Alzheimers, nerve injury and brain damage from stroke. Dr. Andrew Maynard, chief science advisor for the Wilson Centers Project on Emerging Nanotechnologies, and Dr. Mauro Ferrari, chairman, Department of Biomedical Engineeri...Penn researchers report that gene therapy awakens the brain despite blindness from birth
...pport the potential for human benefit from retinal therapies aimed at restoring vision to those with genetic retinal disease.Researchers used functional MRI to measure brain activity in blind dogs born with a mutation in gene RPE65, an essential molecule in the retinoid-visual cycle. The same mutation causes ...Lancet study shows gene therapy for Parkinson's disease is safe and some patients benefit
...lter the underlying disease process. Finding novel therapies are key as many Parkinsons patients stop develop complications after prolonged use of traditional medicines. The Feinsteins David Eidelberg, MD, took brain scans before, during and after the treatment and the scans show that the brain is re-working...New amfAR research grants to optimize HIV treatment
...hing and maintaining the reservoir may lead to new therapies designed to eradicate the virus from the body. S...of the reservoir of virus in semen as a target for therapies aiming to cure HIV infection....JCI table of contents: June 21, 2007
...retinal degeneration in NTG and the development of therapies directed at preventing or treating IOP-independent glaucoma. Title: The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma Author Contact: Kohichi Tanaka Tokyo Medical and Dental University, Tokyo, Japan. Ph...Researchers develop buckyballs to fight allergy
...onse, setting the stage for the development of new therapies for allergy. Allergic disease is the sixth leading cause of chronic disease in the United States, and while various treatments have been developed to control allergy, no cure has been found. These findings advance the emerging field of medicine kno...AAAS decries latest stem cell veto
...he potential to delay development of important new therapies by cutting off a promising avenue of research," said Alan I. Leshner, the chief executive officer of AAAS and executive publisher of the journal Science . The president vetoed a similar bill that passed the Senate and House of Representatives last y...Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state
.... This may ultimately allow us to develop targeted therapies to stimulate adult stem cells within our own bodies to repair damaged tissues, and may provide further areas of exploration for the treatment of cancer....Promising protein may prevent eye damage in premature babies
...ional Academy of Sciences, offers a new target for therapies for retinopathy of prematurity, a potentially blinding disease that annually affects about 15,000 babies. In newborns with the disease, oxygen-starved areas of the retina compensate by quickly growing new blood vessels. But these new vessels are fr...How the Biotech Revolution Is Changing the Way We Fight Disease
...ancer and the first step toward development of new therapies for treating this still baffling disease. This spin-off of the human genome project is only the latest exciting research advance in a decades-long quest to fully understand the biochemistry of the human body and thereby gain insights into the secrets...