Cancer stem cells similar to normal stem cells can thwart anti-cancer agents
TORONTO, June 15 Current cancer therapies often succeed at initially eliminating the bulk of...s and cancer stem cells protect themselves, cancer therapies have to be designed specifically to target cancer stem cells while sparing normal stem cells, she ex...CSHL scientists successfully target tumor microenvironment to stop cancer growth
...e study makes clear that in addition to developing therapies that directly target cancer cells, it is also equally important to develop therapies that target critical non-cancer cells like EPCs....Pre-cancerous blood diseases can be products of their environment
...mental considerations for the success of stem cell therapies more generally, Orkin said. For bone marrow transplantations to work, you will need a decent environment in which to put them, he said. If you put stem cells in an environment that cant support them, it will be as if you didnt transplant them at all....LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
...humans, points to the potential of a new avenue of therapies using retinoic acid to treat these diseases. Whats exciting about this finding is theyve found that retinoic acid plays a role in modulating the switch between these two distinct (T cell) lineages the induced regulatory T cells, which are anti-in...NIH awards nearly $21 million to fund cutting-edge research equipment
...ing causes of disease and the development of novel therapies to treat them, said Barbara Alving, M.D., NCRR Dir...canners will be used to develop minimally invasive therapies at Brigham and Womens Hospital in Boston; and for psychiatric applications at the Nathan S. Kline In...Scientists decode RNA mystery, will help aim drug therapies
...made a discovery that will help better direct drug therapies to their molecular targets. As reported in the Ju...searchers improve their accuracy in designing drug therapies that suppress mutations. You need to know whether youre targeting the near or non-cognate codon to g...U-M researchers discover gene switched off in cancer can be turned on
...nding could lead to a new class of targeted cancer therapies with potential to benefit many different cancer ty...ff. But its a straightforward extension of current therapies that target genes that are turned on, says lead study author David Reisman, M.D., Ph.D., assistant p...Tumor vessels identified by unique molecular markers
...t tumor growth. However, current vascular-targeted therapies may also damage normal growing blood vessels. This...p guide the development of safer vascular-targeted therapies with potentially fewer side effects. ...ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
...for CML patients with the T315I mutation, for whom therapies have been previously lacking." The authors also noted some hematologic toxicities (neutropenia, thrombocytopenia and anemia), but confirmed that the toxicity of HHT was "easy to manage". "We are delighted with this publication that reinforces our bel...University of Liverpool launches 10 million small animal teaching hospital
... Leahurst, Wirral, provides the most sophisticated therapies and treatments available to small animals in the UK. Its facilities include MRI and CT scanning, a keyhole surgery theatre, a radiotherapy unit and digital X-ray technology. The 86-room hospital, servicing the whole of Northern England and North Wa...Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
...ly block individual brain chemicals, hormone-based therapies such as pramlintide work by enhancing existing phy...ays involved in food intake control. By developing therapies based on naturally occurring hormones, it may be possible to help people control how much they eat, ......rimination processes, hopefully paving the way for therapies targeting learning and behavioural disorders." Professor Tonegawa, a frequent world traveler, describing his own occasional experience of finding the airport in a new city uncannily familiar, added: "This occurs because of the similarity of the mo...UC Irvine awarded $3.9 million to upgrade stem cell research facilities, training
...ogy of human embryonic stem cells and their use in therapies for spinal cord injuries, diabetes, multiple scler...for cell transplantation and for testing potential therapies prior to clinical research. Currently, few opportunities exist for researchers to learn both how to ...American Chemical Society's Weekly PressPac -- May 30, 2007
... Tackling the grueling challenge of getting brain therapies across the blood brain barrier" This story will be available on June 4 at http://pubs.acs.org/cen/science/85/8523sci1.html FOR ADVANCE INFORMATION, CONTACT: Michael Bernstein ACS News Service Phone: 202-872-6042 Fax: 202-872-4370 Email: m...ChemGenex reports successful personalized dosing of Quinamed at ASCO
... patients who were refractory to multiple existing therapies and who had advanced tumors, there was evidence of antitumor activity in a range of tumor types. Three prostate cancer showed a decline in prostate specific antigen (PSA), with one of these achieving a partial response. Two patients with ovarian canc...Nexavar significantly extends overall survival by 44 percent in liver cancer patients
...hs in those taking placebo. Because there are no therapies that significantly improve survival for the thousands of patients with liver cancer, these findings demonstrate the compelling study results of Nexavar as the new reference standard of care for the first-line treatment of HCC, said Dr. Josep M. Llove...Stanford researchers find stem cells in colorectal tumors
... he hopes Stanford researchers will develop cancer therapies that specifically kill these cancer stem cells, eradicating the cancer entirely. Current therapies may kill the bulk of the tumor cells, but if any cancer stem cells remain the tumor will resurface o...New treatment increases life time expectancy of patients suffering from advanced liver cancer
...could neither beneficiate from curative effects of therapies nor hope for survival improvement. From a scientific point of view, this drug, which delays tumor progression and improves survival, will be the base for future further research. The SHARP study, an international phase III trial, lead by Hospital C...Genomic signatures identify targeted therapies for lung cancer
...ble to target specific pathways. But because these therapies are effective only in a small percentage of patients, the majority of these drugs go unused. Potti said the genomic signature tests would give patients another option to traditional chemotherapy. The Duke team plans to begin a clinical trial of th......y causes. This is especially attractive as current therapies are associated with significant side effects and a...enues of future research with respect to potential therapies that inhibit thrombin action. TITLE: Strain-dependent embryonic lethality and exaggerated vascular...