Scientists find major susceptibility genes for Crohn's disease
...ant discoveries not only offer new hope for better therapies for patients with Crohn's disease, they also highlight the promise of the human genome project and subsequent investments by the NIH in large scale, collaborative research projects to unravel the causes of, and hopefully better treatments for complex...Stem cells provide new tool for studying disease and identifying ALS drugs
...ease but also provides a target for potential new therapies aimed at slowing motor neuron degeneration in ALS. "That's what happens when scientists from major institutions work together toward shared goals. Project A.L.S. prides itself on building productive research teams from elegant parts," said Valerie...Cetuximab increases survival in advanced colorectal cancer patients, study shows
...improved survival in these patients when all other therapies had failed," said Derek Jonker, M.D., assistant professor at the University of Ottawa and Canadian co-chair of the study. "This is the first time a single agent biologically targeted therapy has demonstrated a survival advantage in patients with colo...Scientists find new genes for Crohn's disease
...s, we may be better able to develop more effective therapies for IBD," said consortium member Richard H. Duerr,...ant discoveries not only offer new hope for better therapies for patients with Crohn's disease, but they also highlight the promise of the human genome project a...Progress toward a targeted therapy for a specific form of leukemia
...ted that MYB might well be an important target for therapies for this group of T-ALL patients. T-cell acute ...tion therapies, which are much more effective than therapies that focus on just one target. A new player Idoya Lahortiga and Jan Cools in Peter Marynens grou...Scientists find major susceptibility gene for Crohn's disease
...ant discoveries not only offer new hope for better therapies for patients with Crohn's disease, they also highlight the promise of the human genome project and subsequent investments by the NIH in large scale, collaborative research projects to unravel the causes of, and hopefully better treatments for complex...Gene that governs toxin production in deadly mold found
...ity of LeaA you might have a novel target" for new therapies to treat Aspergillus fumigatus infection. "The gene is not expressed all the time, which means there must be a signal that says 'turn me on.'" Removing the gene from the equation, she says, may cripple the microbe's ability to infect and sicken p...AACR Annual Meeting showcases significant developments in understanding and targeting cancers
... effectiveness of several new, high-profile cancer therapies and vaccines. "Because of significant diagnostic...apeutic advances such as personalized and targeted therapies that prolong patients lives, the number of people successfully managing and living with cancer conti...The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better
...the successful development of stem cells as viable therapies for a variety of diseases and conditions, according to the studys senior author, Johnny Huard, PhD, director of the Stem Cell Research Center at Childrens and the Henry J. Mankin Professor and Vice Chair for Research in the Department of Orthopaedic ...Mouse FH knockout resembles human renal cell cancer
... tumorigenesis and will allow testing of potential therapies for renal neoplasms, says Dr. Pollard....How do the rules of immunity change during chronic infections?
...tions, could help scientists design more effective therapies to fight chronic infections and certain types of tumors, says Wherry. In previous studies, Wherry had shown that chronically stimulated CD8 T cells were unable to undergo the slow, steady self-renewal process used by the CD8 T cells that persist as......d they are very aggressive, Capecchi says. Current therapies arent very effective. Synovial sarcoma accounts for 7 percent to 10 percent of soft-tissue sarcomas, and usually develops in the arms or legs, particularly near the knees or ankles but also near the hips or shoulders. It also can occur on the tors......s as well as the mechanisms underlying some of the therapies employed to compensate them," explained Stoleru....Study shows isolation of stem cells may lead to a treatment for hearing loss
...hlear cell populations and potentially lead to new therapies for the numerous individuals that are going to suffer from noise-induced hearing loss in the near future....Treatment-induced growth factor causes cancer progression
In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumor...e wondered then if TGF-beta induced by anti-cancer therapies can serve as a survival signal for tumor cells, thus allowing them to withstand therapy and later re...A 'traffic light' for neurons means 'go' for improving brain research
... with neural circuits and could eventually lead to therapies for some disorders. "This accomplishment is a key step toward the important goal of mapping neural circuit dynamics on a millisecond timescale to see if impairments in these dynamics underlie severe psychiatric symptoms," said National Institutes o...Leading researchers honored for progress in cancer prevention, detection and treatment
...and applying these insights to the use of targeted therapies for cancer, will give his lecture "Targeting Genetic Lesions in Cancer: Lessons from EGFR and MET," at noon on Tuesday, April 17, in Hall A of the Los Angeles Convention Center. Thomas W. Kensler, Ph.D., Professor in the Department of Environm...Genomic test could help detect radioactivity exposure from terrorist attacks
...iate level of exposure that may respond to medical therapies or an inevitably lethal dose. The researchers published their findings April 3, 2007, in the journal Public Library of Science (PLoS) Medicine. The research was funded by the National Institute of Allergy and Infectious Diseases. High doses of r...Preventing and treating lung cancer -- ESMO explores collaboration to fight cancer on all fronts
...ic testing can improve the outcome of new targeted therapies for lung cancer (William Gullick, GB, Rolf Stahel, CH, and Giuseppe Giaccone, US) The major impact on survival time that will come from a new system for assessing the severity of patients cancer (Peter Goldstraw, GB, Didier Lardinois, CH) New...Gladstone scientists identify critical gene factor in heart development
...fellow and lead author on the paper. "Although any therapies are a long way off, understanding the effects of miR-1-2 is very exciting," added Joshua Ransom, a graduate student who contributed equally to this work."...