Gene mutations linked to hereditary lung disease
...mune attack against the lungs, even though current therapies aimed at dampening the immune system dont work," she explains. "If were not so tied to immune suppression therapies, we could eventually tailor drugs to a different target."...Scientists identify a candidate gene for osteoporosis
...onfirmed in humans, then we may be able to develop therapies that are based on inhibiting the function of the DARC gene," explains Dr. Subburaman Mohan, Ph.D., a Senior Scientist at the Loma Linda VA Medical Center and a Professor of Medicine and Biochemistry at Loma Linda University. "We will also be able t...Toward improved forms of a time-tested cholesterol-fighter
...ctivity than niacin, better tolerated HDL-targeted therapies with improved efficacy could provide additional clinical benefits to patients and potentially reduce the risk of heart attack and stroke. Semple described research toward that goal, including Arenas discovery of a niacin receptor termed GPR109a. It...Gene test shown to measure heart function after transplant
...unction may provide a valuable tool to help tailor therapies to meet the specific needs of each heart transplant patient," said Dr. Deng. Until recently, following a heart transplant, patients had to go through invasive heart-muscle biopsies to check for organ rejection. The GEP test is a non-invasive alter...Stem cell therapy shows promise in regenerating damaged muscle in heart attack patients
...iven to patients through a standard IV line. Other therapies require delivery to the site of the disease through catheterization or open surgical procedures, but this one was very simple and easy for the patient. Schaer says the cells were grown in culture to very high numbers, allowing a single donor's cell...Stem cell therapy shows promise for rescuing deteriorating vision
..." Lund has experimented with other cell types as therapies for preserving vision. The neural progenitor cells, a cell model developed by Wisconsin stem cell researcher Clive Svendsen, have been used experimentally to deliver the same growth factor in models of Parkinson's disease and Lou Gehrig's disease. Sv...ACS News Service Weekly PressPac -- March 21, 2007
...ctivity than niacin, better tolerated HDL-targeted therapies with improved efficacy could provide additional clinical benefits to patients and potentially reduce the risk of heart attack and stroke, Semple explained. Semple described research toward that goal, including Arenas discovery of a niacin receptor ...Researchers identify key protein in immune response to malaria and TB
...ctious diseases. The insights suggest possible new therapies to tackle these major global diseases. Professor Luke O'Neill from Trinity College Dublin, Ireland, identified the protein in 2001. The protein, known as Mal, alerts the immune system to respond against invading bacteria. Now, Professor Adrian Hill...Targeting tumors the natural way
... on healthy cells, too - albeit in lower numbers - therapies aimed at these receptors are always expected to have debilitating side effects. That's why Kiessling's approach holds such promise. "What we've shown is that you don't need a receptor that's found solely on tumor cells," she says. "You just need one ...The Parkinson's Institute to conduct Phase III Clinical Trial of creatine for Parkinson's disease
...ous studies looking at potential disease modifying therapies were limited to a select group of very early patients." This study follows patients that are still early in the disease process but already taking medications for their symptoms. Not only does this allow more patients to participate, it also genera...San Diego stem cell consortium tops in state funding
... that will accelerate the development of cures and therapies for some of humanity's most devastating diseases, including Parkinson's and Alzheimer's diseases. The consortium also will expand research and academic efforts in developmental biology, bioinformatics, regenerative medicine ethics, student training a...UBC discovery may lead to 'smart' therapies for breast, ovarian cancer
New non-toxic and targeted therapies for metastatic breast and ovarian cancers may now ... for Drug Research and Development to identify new therapies to combat metastasizing cancer. The researchers say information from this discovery may speed dev...$7.9M awarded to UCI stem cell scientists
...to make specialized cell types both for cell-based therapies and to develop drugs to treat diseases. Because human embryonic stem cells are derived from early embryos, his studies also could have a major impact on the understanding of early embryo growth and factors that cause infertility. Also today, the IC...JCI table of contents: March 15, 2007
...ause tumors for many years, there are no effective therapies for the treatment of KSHV-induced tumors. Now, researchers from the University of Helsinki, Finland, have found that the small-molecule inhibitor Nutlin-3a has antitumor effects in a mouse xenograft model of PEL. In the study, which appears online o...UNC scientists discover cellular 'SOS' signal in response to UV skin damage
...me cells more resistant to certain types of cancer therapies which work by inducing the cancer cell to die. If the cell, even if it is a cancer cell, is given this additional time to recover from treatment, it may be able to survive it, much to the detriment of the patient." Kaufmann said. Ultraviolet radia...Researchers identify molecular basis of inflammatory bowel disease
...ion people worldwide. The development of effective therapies against these diseases requires an understanding of their underlying molecular mechanisms. Researchers from the Universities of Cologne and Mainz in Germany, the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy and thei...Study reveals how some molecules inhibit growth of lung cancer cells
...acology at Harvard Medical School. "These targeted therapies likely would be less toxic as they, in theory, would not affect the normal functioning EGFR proteins."...Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease
...d the fact that, in the future, the mostsuccessful therapies - including those employing stem cells -- willlikely invoke the use of multiple strategies in concert. Indeed, thestem cell may be the "glue" that ultimately holds these therapiestogether in an effective manner by virtue of its fundamental biology. ...MIT particles pave way for new bedside diagnostics
...ized diagnostic therapy. This method for tailoring therapies to each patient could be a breakthrough for treating diseases like cancer and cardiovascular disease. The particles could also be used to genetically profile individual patients and screen for bioterrorism or other hazardous environmental agents.......stage, the more likely we'll be able to design new therapies that eliminate them. That could help us continue our successful efforts to increase the survival rate of ALL." One potential strategy for eliminating leukemic cells would take advantage of the discovery that mutations in the B-cell differentiation...