Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...velopment of NF-κB pathway inhibitors for the therapy of MM, offers Dr. Staudt. In a separate study, Dr. Rafael Fonseca, from the Mayo Clinic Arizona, and colleagues report mutations in several genes that result in constitutive activation of the alternative NF-κB pathway. We propose that the acqu...ESF EURYI award winner aims to stop cancer cells reading their own DNA
A promising new line in anti-cancer therapy by blocking the molecular motors involved in copyi...d to cut out the cancerous tissue, while radiation therapy can kill the malignant cells, and chemotherapy stops them dividing. Dekkers work is aiming towards a...Smokeless tobacco more effective than cigarettes for delivering dangerous carcinogens into the body
...oking is the long term use of nicotine replacement therapy as a means to reduce dependence. In fact, this study lends evidence to support the notion that the oral use of tobacco actually provides a more efficient means for delivering certain carcinogens into the body through the bloodstream, although cigar...Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
...use. Despite the controversial data about estrogen therapy in clinical studies, the results of this study performed in aged rats suggest that the loss of estrogens after menopause may contribute to the development of obesity and hypertension, opening new therapeutic approaches to postmenopausal hypertension....Testosterone replacement therapy: How safe for aging men?
...derly American men taking testosterone replacement therapy was nearly 819,000, and the number is growing. The increased use has occurred despite the fact that the cardiovascular effects of chronic testosterone treatment in aging males are largely unknown, and the safety of testosterone replacement has not be...Research aims to identify markers for menopausal women at risk for deadly blood clot
AUSTIN, TX In women, hormone therapy is a risk factor for venous thrombosis, a blood cl... tools that will allow doctors to provide hormonal therapy for their female patients that is commensurate with a womans risk for venous thrombosis. ...Grapes, soy and kudzu blunt some menopausal side effects
...r these problems was long-term hormone replacement therapy (HRT). Since then, studies have shown that extensi...ols could eventually provide effective stand-alone therapy for post-menopausal women, but in the future they may provide effective adjunct therapy that complem...American Chemical Society's Weekly PressPac -- Aug. 1, 2007
...sushi Ogiwara and colleagues point out that cancer therapy already is moving toward individualized treatments selected according to tumor cell type and patients predicted responses to different kinds of anti-cancer drugs. Their paper describes key features of state-of-the-art proteomic profiling, in which bl...Research team enlightens the reasons for severe blindness
...be helped by exchanging this gene. Such a LCA gene therapy has been already successfully implemented for dogs...prove to be withstandable, there will also be gene therapy available for LCA5 gene deficiencies in five to ten years time, says Ueffing. The affected persons u...Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
... true yet - then these findings may provide a gene therapy approach for treating sickle cell anemia and beta-thalassemia. It is well-established that the expression of embryonic globin genes can help ameliorate these diseases, said Joyce A. Lloyd, Ph.D., associate professor of human genetics at the VCU Masse...UF, French scientists seek test to detect gene doping in athletes
... to detect that" asked one of Frances leading gene therapy researchers, Philippe Moullier, M.D., Ph.D., an ad...s panel on genetic doping and director of the gene therapy program at the University of California, San Diego. It sounds futuristic, but experts say its onl...Defects in critical gene lead to accelerated lung tumor growth
...make better treatment decisions depending on which therapy is most likely to target that defect. Currently, Hayes and his colleagues are looking at cancer progression in patients from this study to see how specific LKB1 mutations correlate with clinical outcomes. ...Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
...o fertilization as a form of assisted reproduction therapy for infertility. Parthenogenetic ES (pES) cells are derived from embryos created by artificial activation of eggs in the absence of sperm. ES cells generated by somatic nuclear transfer (ntES) are derived from embryos that are created when the nucleu...JCI table of contents: August 1, 2007
...ing where genes can successfully integrate Gene therapy -- whereby a retrovirus that integrates into the g...viral integration in individuals treated with gene therapy is therefore of utmost importance to the further development of such gene therapy approaches and thr...U-M researchers find family of 'on switches' that cause prostate cancer
... prostate cancer. Androgen deprivation is a common therapy for prostate cancer. Knowing which gene fusion i...f an androgen-regulated gene is involved, androgen therapy would be appropriate. But if the gene fusion involves a gene that represses androgen, the anti-andro...Aggressive therapy best for certain AML patients
... patients who have the mutation with an aggressive therapy such as an autologous stem cell transplant while t...of that damage helps doctors determine a patient's therapy and estimate the patient's prognosis. The remaining AML cases have cancer cells with normal-looki...Under magnetic force, nanoparticles may deliver gene therapy
... it may represent a new method for delivering gene therapy to benefit blood vessels damaged by arterial disea...he feasibility of using the nanoparticles for gene therapy in blood vessels damaged by vascular disease. He suggested that the nanoparticles might find broader...Investigating antibiotic use in acute care patients
... "This creates a real problem because subsequent therapy with a second antibiotic may be ineffective because resistance against the second antibiotic had already been increased by the first antibiotic." In the United States an estimated 10 percent of patients get sick because of infections acquired whils...JCI table of contents -- July 26, 2007
... injury, and as such are a potential target in the therapy of spinal cord injuries. The authors showed that...rd injury, and as such may constitute a target for therapy in spinal cord injury. TITLE: Endothelial sulfonylurea receptor1regulated NC[Ca-ATP] channels medi...Study points to new way to predict death risk from torn aorta
...ical trials comparing stent grafts to best medical therapy in aortic dissection have suggested similar outcomes for both, so they are not to be entered into lightly. If the false-lumen thrombosis risk model pans out as a useful tool for physicians, it might be recommended that an examination of the extent...