Study identifies new gene therapy tools for inherited blindness
July 25, 2007 -- An improved approach to gene therapy may one day treat some of the nearly 200 inherited...ness are turned on. "In its most basic form, gene therapy requires three components," explains Joseph Corbo, M.D., Ph.D., assistant professor of pathology and...Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
...a certain enzyme, Banks says. Enzyme replacement therapy or putting the missing enzyme into the bodies of those who have Sly Syndrome holds promise in treating the physical problems of the disease. In the case of Sly Syndrome, the missing enzyme is more than 1,000 larger than a sugar molecule and so h...Other highlights in the July 24 JNCI
...lleled trends in mammography screening and hormone therapy use, while a recent decline in incidence was consistent with a drop in hormone therapy use, according to a study of a large group of women enrolled in a single health plan,. Breast canc...Breast cancer and hormone therapy -- A looking-glass mirror?
...hether, and to what extent, postmenopausal hormone therapy (HT) use is associated with a higher risk of breast cancer, says Professor Amos Pines, President of the International Menopause Society. Although it is agreed that long-term HT slightly increases that risk, the definition of long-term use is still un...CTRC enrolls first patients in novel phase II study for sarcoma -- living virus destroys cancer cell
...ccurs naturally in the environment. This novel therapy has shown success because the reovirus replicates ...and kill it. REOLYSIN typifies the true targeted therapy approach that seeks to use fundamental differences between cancer and normal cells as the basis for ...Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
...at treatment soon after injury combining radiation therapy to destroy harmful cells and microsurgery to drain...hour after injury, followed by localized radiation therapy given for ten days starting on day ten after injury, there was nearly a two-fold improvement in the ...Enzyme discovery sheds light on vitamin D
...wn by our bodies. The effectiveness of vitamin D therapy is partly dependent on how quickly it will be broken down, says Biochemistry Professor Glenville Jones, an expert in the field of vitamin D metabolism. By studying the enzyme responsible for breaking down the vitamin, we hope to develop a way to prev...Adult survivors of childhood leukemia exercise less, worsening high risk for obesity and illness
...vity among all adults, suggesting that the type of therapy administered to a child may impair his or her phys...earchers said. Though the addition of CRT to ALL therapy over 40 years ago led to a marked increase in survival rates, research has since linked CRT to reduc...Pediatric ritalin use may affect developing brain, new study suggests
...ncouraging, and supports the notion that this drug therapy may be best used over a relatively short period of time, to be replaced or supplemented with behavioral therapy," Dr. Milner says. "We're concerned about longer-term use. It's unclear from this study whether Ritalin might leave more lasting changes, ...Cardiac patches stimulate regeneration, improve function after heart attack
...s. The most elegant approach would be systemic therapy finding the most relevant parts of the periostin molecule and giving it by infusion, he says....Co-operation between GSF and clinic improves outlook for sarcoma patients
...to operative removal of the sarcoma. This combined therapy has been applied already to a large number of pati... clinical analysis of deep hyperthermia for cancer therapy up to biological research in the areas of immunobiology and cell biology. The head of the Clinical C...Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
...ts are given several cycles of drugs and radiation therapy before undergoing surgical procedures to remove th...phageal cancer were deemed suitable for multimodal therapy if they fulfilled a list of pre-set criteria, including being younger than 77 years, fit for surgery......IM) treatment strategies, in which brief intensive therapy is used to reduce host viral levels, which is then...Biology, clinical responses to antiretroviral drug therapy are simulated for the first time, and the model is then applied to IM therapy. Marcel Curlin, Shyama...One man's junk may be a genomic treasure
...cture or meaning to these genes, would render gene therapy ineffective. ...JCI table of contents: July 12, 2007
...c inhibitors may prove beneficial in breast cancer therapy Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alphanegative cancers are more aggressive and have a worse progno...Antibody retards growth and induces death in liver cancer cells
...re very excited because this is the first targeted therapy for liver cancer. Other therapies have some modest benefits, but no one knows exactly how they work. We now have identified a pathway that appears to be overly active in more than 70 percent of the cancers we examined and, when targeted, leads to sig...Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
...they can be more readily used for future clinical therapy to regenerate damaged tissue such as neurons for Parkinsons disease, or insulin producing cells for diabetes . The research has been funded by the Canadian Institutes for Health Research and the National Cancer Institute of Canada. The Nature art...Has science unearthed the Holy Grail of pain relief?
...mpson. Inhibiting P2X as a potential pain-relief therapy would be the Holy Grail of rational drug design and could revolutionise the way we manage chronic pain conditions like back pain and migraine. ...New use for a cell toxin found to inhibit survival proteins in cancer cells
...ce to multiple types of chemotherapy and radiation therapy found in many types of cancers. In a paper publish...her agents, and could lead to a targeted molecular therapy to enhance the effectiveness of cancer treatments. Hockenbery said his groups approach illustrated t......erhaps the most famous hemophilia patient. Gene therapy Regular injection of the right coagulation factor...y possible treatment for hemophilia patients. Gene therapy might well be an alternative solution. In this approach to curing the disorder, a malfunctioning gen...