Oncolytics Biotech Inc. proceeds to initiate US Phase II sarcoma clinical trial
...Patients may receive additional five-day cycles of therapy every four weeks for a maximum of eight cycles. Up to 52 patients will be enrolled in the study. ...Study pries into ovarian cancer's deadly secrets
...e typically large and often metastatic. Standard therapy for ovarian cancer now usually involves surgery to remove the tumor, followed by chemotherapy, which is initially effective but not curative. The disease frequently comes back in a drug-resistant form. New drugs are badly needed that can target the d...Brain tumors coax important support from nearby immune system cells
...erapeutic standpoint, we're very focused in cancer therapy on poisoning the cancer cell," Gutmann says. "But why not also deprive the cancer cell of the growth signals it receives from the normal surrounding tissue? These cells may actually decide whether a tumor forms at all and whether it continues to grow...Veterinary scientists explore poultry virus as cancer killer
...g to Subbiah, the use of poultry viruses as cancer therapy poses no threat to humans and several other oncolytic viruses are currently being explored to treat cancer. However, Subbiahs work is the first to alter Newcastle disease virus through a reverse genetic system to target prostate cancer specifically. ......he cancer originated. The only way to develop a therapy that is specific for this cancer is to understand ...r this specific cancer and, second, you can design therapy for sarcomas in general because they share many common features with synovial sarcoma, says the stud...UC Davis study finds high arsenic levels in herbal kelp supplements
...d extract. The kelp supplement was the only herbal therapy shetook regularly throughout the course of her ill...up to her primary care. "It's unfortunate that a therapy that's advertised as contributing to'vital living and well-being' would contain potentially unsafe l...Tumors stopped from spreading to new sites
...he blood after surgery, chemotherapy, or radiation therapy correlate with increased risk of early metastasis ...ests that monitoring TGF-beta levels after primary therapy might indicate the patients most at risk of developing tumor metastases and that treatment with TGF-...Study shows isolation of stem cells may lead to a treatment for hearing loss
... The team's research is a major step in devising a therapy to reverse permanent hearing loss because it may lead to the activation of cochlear stem cells in the inner ear to regenerate new hair cells. Clearly we have miles to go before we reach our end goal, but the exciting part is now we can test compound...JCI table of contents -- April 5, 2007
...he blood after surgery, chemotherapy, or radiation therapy correlate with increased risk of early metastasis ...ests that monitoring TGF-beta levels after primary therapy might indicate the patients most at risk of developing tumor metastases and that treatment with TGF-...Treatment-induced growth factor causes cancer progression
...l for tumor cells, thus allowing them to withstand therapy and later recur," said Arteaga, professor of Medic... This appears to be the case, he said. Radiation therapy and the chemotherapeutic agents doxorubicin and docetaxel all increased TGF-beta levels and accelera...A 'traffic light' for neurons means 'go' for improving brain research
...euronal activity with light could someday become a therapy in itself. A neural traffic light To selectively take control of neurons, the researchers used a virus to insert genes for producing light-sensitive proteins into cells of interest. The gene ChR2 is derived from an algae that makes affected neu...NIDA study identifies genes that might help some people abstain from smoking
...a step closer toward tailoring individualized drug therapy for addiction based on an individuals unique genetic makeup. This research marks the first time weve been able to identify genes involved in the ability to quit smoking, says NIDA Director Dr. Nora D. Volkow. It marks a movement from identifying t...Recent declines in breast cancer mortality greatest in women under 70
...at older women are less likely to receive adjuvant therapy for breast cancer. Because older women are under-represented in clinical trials, their optimal treatment has not been well established. The researchers point to the importance of further reducing mortality rates among women over 70 and women with E...Selective amnesia -- How a traumatic memory can be wiped out
...once more stored in the long-term memory. Is drug therapy capable of wiping out the initial memory, and only that memory? The scientists trained rats to be frightened of two distinct sounds, making them listen to these sounds just before sending an electric shock to their paws. The next day, they gave ha...Advances in personalized medicine on agenda for 54th Society of Nucelar Medicine Annual Meeting
...TON, Va. -- The potential of molecular imaging and therapy and the power of nuclear medicineand their impact ... biological targets or pathways in the bodyand its therapy value will be at the forefront of personalized medicine, eventually providing patient-specific infor...Stem cell therapy shows promise for rescuing deteriorating vision
...Lund, who has conducted pioneering studies of cell therapy for eye disease. "We didn't expect that at all. We've used a number of different cell types from different sources and these have given us the best results we've ever got." How the cells act to preserve the deteriorating eye cells remains unknown, ...Nanoparticles for delivery of prostate cancer treatment
...n to expand research on the delivery of a targeted therapy for prostate cancer using nanoparticles. Garen ...pid-covered, gene delivery packets to deliver the therapy in animal models of human metastatic prostate cancer. "While we can directly inject the purified ...Ultrathin films deliver DNA as possible gene therapy tool
MADISON - Gene therapy - the idea of using genetic instructions rather than drugs to treat disease - has tickled scientists' imaginations for decades, but is not yet a viable therapeutic method. One sizeable hurdle is getting the right genes into the right place at the ri...Clinical trial for diabetic macular edema
...ing and safety information, as well as combination therapy of ranibizumab and laser photocoagulation (which has been the standard therapy for DME). The study consists of a two-week screening period, a six-month active treatment period, a......tify lung cancer patients who need more aggressive therapy after surgery. The protein is the product of a gene called Olig1, which previously has not been linked with lung cancer, and it is located in a chromosome region that is often lost in the tumor cells of many lung-cancer patients. The research e...