Commandeering cellular machinery: recognition mechanism to detect small molecules
...d to such important molecules as steroid hormones, thyroid hormones and vitamin D. The development could provide a foundation for a new family of biologically-based mechanisms able to detect common drugs, chemical weapons and other small molecules. By allowing manipulation of this cellular protein machine......present throughout tissues such as muscle, spleen, thyroid gland, the testes, and the cerebellum, but they didn't expect that knocking out the receptor would have such broad effects. "TR4 is a master regulator that binds to other genes and turns on or blocks other genes," Chang says. "Now we know that...New version of tumor-suppressor linked to progression of childhood cancer
...sociated with many human cancers, including colon, thyroid and prostate cancers. However, previous studies have suggested that TrkA acts as a tumor-suppressor in NB. Dr. Andrew R. Mackay and colleagues from the University of L'Aquila in Italy found a previously undiscovered variant of TrkA, called TrkIII, wh...ORNL system eliminates perchlorate, helps scientists trace source
...ent system. Perchlorate, or ClO4-, disrupts the thyroid gland that regulates metabolism in adults and physical development in children and is increasingly being found in soil and water. It is used to make solid rocket propellant and explosives but also occurs naturally, as in nitrate soils from Chile used...Thyroid treatment can trigger homeland security detectors
...dical procedures such as iodine therapy, a popular thyroid treatment, can result in patients triggering radia... FDG PET scan less than 24 hours Bone and thyroid scans 3 days Cardiac exams with thallium up to 30 days Iodine therapy up to 95 days Dr. Zucki...$6.7 million for bionic war on disabilities
...stroke; trauma; damage during surgery of the neck, thyroid or chest; or a tumor that impinges on the nerve to the vocal fold. "This device is going to be used in an attempt to reanimate the vocal folds to restore the normal movement, both the opening and closing movement of the vocal folds," Smith says....Flame retardant exposure linked to house dust
... in developmental, reproductive, neurotoxicity and thyroid effects in rats, mice and fish, and may be carcinogenic. Researchers in Europe and the United States found concentrations of PBDEs higher in Americans than in Europeans, although it is not known if these levels affect human health. Some studies ha...JCI table of contents, 3 January 2005
...study of Chernobyl residents uncovers new cause of thyroid cancer Cincinnati University scientists studying papillary thyroid cancer in Chernobyl residents following the 1986 nuclear plant accident have identified a novel gene...Cincinnati study of Chernobyl residents uncovers new cause of thyroid cancer
...incinnati University scientists studying papillary thyroid cancer in Chernobyl residents following the 1986 n...can convert a cell into a tumor cell) in papillary thyroid carcinomas that developed in patients exposed to radiation at Chernobyl. Their results are published...ASBMB-Amgen Award Lecture to focus on orphan nuclear receptors
...structurally related to the well-known steroid and thyroid hormone receptors that act to mediate the actions of steroid, thyroid, and retinoid hormones. These endocrine pathways represent a cornerstone of biomedical research and have led to treatments for breast cancer, inflammatory disorders and other patho...Journal of Nuclear Medicine Supplement summarizes current molecular radiotherapy
...cal practice for a growing number of patients with thyroid cancer, lymphoma, metastatic bone involvement with...nt segment of the treatment population--women with thyroid cancer--one that has the distinction of being the most rapidly increasing in incidence in this count...Report assesses health implications of perchlorate ingestion
...lorate, a chemical that in high doses can decrease thyroid function in humans and that is present in many pub...f iodide, which is essential for the production of thyroid hormones. One potential consequence of that effect is low thyroid hormone production, or hypothyroi...Scientists reveal cells' 'energy factories' linked to cancer
... person to cancer of the kidney, adrenal gland and thyroid gland. Changes in SDH activity may also be associated with stomach and bowel cancer. "This study is exciting because it is the first to find a molecular mechanism that links mitochondrial mutations to tumour formation. Increasing our understanding o...US government list of cancer-causing agents grows
...re is linked to an increased risk for leukemia and thyroid cancer. Exposure during reproductive years increases the risk for breast cancer, and exposure later in life increases risk for lung cancer. Exposure to X-radiation and gamma radiation has also been shown to cause cancer of the salivary glands, stomac...Perchlorate found in dairy and breast milk samples from across the country
...vironment, can interfere with iodide uptake in the thyroid gland, disrupting adult metabolism and childhood d...levels of iodide in breast milk, which can inhibit thyroid function in nursing womenan essential component for proper neural development of the fetus. Although...JCI table of contents, April 1, 2005
...vation of Ras and B-Raf genes are common events in thyroid cancer, labeling these three as oncogenes (genes t...emonstrate that the three oncoproteins involved in thyroid cancer activate a common signaling network in thyroid cells that stimulates cell proliferation and m...Cancerous or harmless? Three genes might tell the tale
... that physicians can distinguish between a type of thyroid cancer and an identical-looking, non-cancerous thyroid condition by simply determining the activity of three genes. The findings could lead to a test that ...Gene mutated in cancer found in some with autism
...person's risk of developing cancers of the breast, thyroid and uterus. PTEN mutations are also found in sever...n-inherited (i.e., spontaneous) cancers, including thyroid and endometrial cancers and some brain tumors. The findings, published in the April Journal of Medic...Why do amyloid diseases strike different tissues?
...h the liver secretes into the bloodstream to carry thyroid hormone and vitamin A. Normally, TTR circulates in the blood as an active "tetramer" made up of four separate copies, or protein subunits, that interact with each other. These tetramers, normally composed of identical protein subunits, come from two......ing foam and furniture upholstery. It disrupts the thyroid function and the functioning of the nervous system in mammals. The researchers only found the alpha isomer of HBCD in the blubber of porpoises and dolphins. Boon's team were Bart Zegers from the Institute for Biodiversity and Ecosystem Dynamics (Univ...