American Chemical Society's Weekly PressPac -- Aug. 8, 2007
...ging agents that pinpoint the location of diseased tissue in the body. However, the question of whether these nanomaterials are toxic to living cells or organisms has not been fully answered, the researchers explain. The scientists used laboratory tests on human lung cells to show that luminescent silica ...NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...ons unknown turns on itself and attacks the muscle tissue and sometimes skin, joints and lungs, causing rash, arthritis and shortness of breath. The University of Pittsburgh-led study will evaluate the effectiveness of a drug called rituximab in adults and children diagnosed with dermatomyositis (a disea...Unravelling new complexity in the genome
... regulatory events involved in specifying cell and tissue type characteristics appear to be considerably more extensive than appreciated in previous studies, says Blencowe. These findings also have implications for understanding human diseases such as cancers, since we can anticipate a more extensive role f...Newly created cancer stem cells could aid breast cancer research
...sive, deadly tumors. In initial experiments, a few tissue slices revealed a primary tumor structure that res...avioral difference by taking a single human breast tissue sample, splitting it in two and growing the cells in the two culture mediums, which select for diffe...High blood pressure, low energy -- a recipe for heart failure
...ively, the heart walls thinned, fibrous connective tissue accumulated and some heart cells died. They also saw that the hearts had depleted fuel reserves. Kelly indicates that these studies show for the first time that changes in the ability of the heart to produce energy lead to heart failure in some case...Abnormal fat metabolism underlies heart problems in diabetic patients
...een analyzing the fat (lipid) composition of heart tissue from laboratory mice with diabetes. They have found that heart cells of diabetic mice lose an important lipid from cellular components that generate energy for the heart, and their latest research shows this happens at the very earliest stages of dia...OHSU turns mouse into factory for human liver cells
...ving sources are difficult to expand in laboratory tissue cultures. In the last decade, scientists have studied whether mice could be genetically engineered and bred to grow human liver cells. Early results since 2004 showed it could be done, but the mice were difficult to breed, the time window for tran...New test improves detection of liver cancer
...healthy liver tissue, and the accumulation of scar tissue disrupts the development and functioning of this complex organ. Cirrhosis of the liver has various causes, including: excessive use of alcohol, chronic viral hepatitis B, C and D infections, diseases of the bile ducts, and parasitic infections. Hal...Female gender provides an advantage in renal diseases
... kidney because it can suppress the growth of scar tissue as well as affect various growth factors which impact the kidney. Research Update: Estrogen in Renal Disease Previous studies using animal models have used hormonal manipulation to explore the effects of sex hormones on renal disease. In these...Sugar and spice and everything nice: Health differences in newborn girls and boys
...hey considered whether a more rapid development of tissue acidity (acidosis) in the heart during a lack of b... against acidosis, was also determined in baseline tissue alone. The researchers found that the newborn female hearts had accumulated a significant 47 perce...Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
...d a major study analysing ductal carcinoma in situ tissue samples using its novel Breast Cancer DSA microarray. DSA research tools focus on the transcriptome of an individual disease, in this case breast cancer, and contain significant additional data, relevant to the disease of interest that is not availa...Other highlights in the Aug. 7 JNCI
...ients. They found 11 genes in noncancerous lung tissue that classified stage I lung cancer patients accor...ue gene expression signature of noncancerous lung tissue and corresponding tumor tissue in lung [cancer] predicts metastasis and disease progression. These f...Gene variant is associated with brain anatomy, clinical course of ADHD
...cit/hyperactivity disorder (ADHD) and with thinner tissue in areas of the brain that handle attention, but a... 7-repeat form of DRD4 was associated with thinner tissue in areas of the brain known to control attentionthe right orbitofrontal/inferior prefrontal and post...UCF research links proteins, stem cells and potential Alzheimer's treatment
...ieve that once scientists figure out how to create tissue from stem cells, most of the diseases that plague ...ble to manipulate stem cells for creating specific tissue types the brain, the eyes, the heart but every disease is different, he said. Simply producing tra...Not all embryonic stem cell lines are created equal
...lf-renewal and of differentiating into any type of tissue in the body. Researchers believe they hold the potential for generating neural, cardiac and other cells that can be implanted to restored damaged tissue. To the best of my knowledge, until now there have been few functional studies of the neurons der...Multicenter study nets new lung tumor-suppressor gene
...is." An examination of human non-small-cell lung tissue suggests LKB1 mutations play a role there as well. Of 144 samples analyzed, 34 percent of the lung adenocarcinomas and 19 percent of the squamous cell carcinomas contained abnormal versions of the gene, researchers report. "We were surprised at how...How cells change the pace of their steps
...essential for many physiological processes such as tissue renewal and the function of the immune system. Cell motility also is an essential part of embryonic development as fetal cells undergo an orchestrated migration to form functioning tissues and organs. Poorly regulated cell motility during embryonic d...Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
...n pES cells might represent a favorable source for tissue replacement therapies, says Dr. Daley. ...Discredited Korean embryonic stem cells' true origins revealed
...matched to the egg donor at the genes that control tissue typing, and are attempting to create similar cells...the mother, as it does in parthenogenesis, reduces tissue compatibility issues. "There has been an advance in the idea that you can couple parthenogenesis a...Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
...ionship ants have with aphids, which feed on plant tissue known as phloem sap that carries nutrients through the tree, Mooney said. While some ant species "tend" aphid colonies -- protecting them from predators in exchange for their carbohydrate-high "honeydew" secretions - feeding activity by birds can di...