St. Jude study shows genes play an unexpected role in their own activation
...stimulate many different genes, depending on which tissues are using it and which signaling molecule caused cAMP to put CREB to work, Brindle said. It is another clue to how CREB might activate the genes for enzymes that make glucose in the liver, while activating different genes in the brain that are key to...Stem cell licensing deal positions Toronto as world leader in technology
...uilding blocks for the muscle, bone and connective tissues of the body. HUCPVCs also serve as regulators of the immune system. Published uses of mesenchymal cells in cell therapy include combating auto-immune and inflammatory diseases (Crohns, juvenile diabetes and rheumatoid arthritis), cancer, heart disea...MU maps course for improving pre-college science education
...those cells navigate in three-dimensional space as tissues and how organizations are patterned during development. We are using this sense of direction, movement and geography that is intrinsic in humans as a metaphor for the instructions that determine movement of cells during development, said William Folk...Rutgers, Penn researchers capture research dollars to improve prostate cancer diagnostic methods
...region and reduce collateral damage to neighboring tissues and organs. The researchers are also applying CAD techniques to histology, or the detailed analysis of tissue samples taken during biopsies. Just as radiologists differ in their interpretation of prostate images, pathologists may assign different s...Researchers develop buckyballs to fight allergy
...ntaining histamine. They are present in nearly all tissues except blood. When mast cells are activated, infla... number of cytokines are rapidly released into the tissues and blood, promoting an allergic response. The researchers found that the unique structure of the ...Surprising origin of cell's internal highways
... how the invasion of cancer cells into surrounding tissues could be halted. ...Research finds that circadian rhythms dominate all life functions
... to be oscillating in the same phases in different tissues or organs. In fact, only about 5 percent of all genes fall into the same phase or timing of peaks and valleys. Synchronization with the activity of the other genes and genes in different organs is a very important and highly specific part of gene fun...Bacteria ferry nanoparticles into cells for early diagnosis, treatment
...he method might be used to take images of diseased tissues by inserting a cargo of fluorescent molecules into tumors that are ordinarily too small to be detected, said Demir Akin, a research assistant professor of biomedical engineering who specializes in nanomedicine. "These bacteria can potentially deliv...'Lucky 13' as new gene discovery offers further hope for childhood blindness
...eptors in the retina. Lebercilin is found in other tissues as part of the cilia, finger-like projections from the surface of cells capable of moving molecules around. However, mutations in the LCA5 gene only appear to cause defects in the retina. "We already know of a dozen genes which, when mutated, cause...Tumor vessels identified by unique molecular markers
...stinguish between growing blood vessels in healthy tissues and those that are associated with tumors. This is a significant finding because this distinction, particularly at a molecular level, has remained elusive for quite some time. The research, released in the June issue of the journal Cancer Cell, publi...Migration alert -- How tumor cells home in on the lymphatic system
...art of their intercellular drainage job, lymphatic tissues secrete small quantities of a signaling molecule. Cells migrate towards high concentrations of this molecule, so if they are close enough to the lymphatic to sense the molecule, they will migrate towards the vessel. Swartzs group showed that tumor ce...Studies to find better ways to preserve human eggs, ovarian tissue under way
...e rapid method of cryopreservation that transforms tissues into durable glass-like structures. Phase I tria...an tissue and eggs. They start with reproductive tissues because young women with cancer produce a compelling need and are a good model for other tissues and...Ethanol injection helps manage bone metastasis in thyroid cancer patients
...in which cancer (malignant) cells are found in the tissues of the thyroid gland. The thyroid gland, located at the base of the throat, makes important hormones that help the body function normally. Cancer can spread beyond that site and invade other parts of the body (metastasis), and thyroid cancer is often...PET/CT use expands: Effectively diagnosing graft infections
... the involved implant, while infection of the soft tissues in the vicinity of the graft requires mainly intravenous administration of high doses of antibiotics, she noted. Israel explained that diagnosing a prosthetic (biological or synthetic) vascular graft infection can be a clinical challenge, andmaking...What's going on in the body? Advanced time-of-flight PET takes a superior 'look'
...PET picking up metabolic signals of body cells and tissues and CT offering a detailed map of internal anatomy. Using the Philips Gemini TF PET/CTthe only clinical PET/CT machine with TOF in the worldinformation was reconstructed for 30 patients, comparing images using the standard acquisition time of 30 mi...PET/CT should be 'first-step' test for patients with Crohn's disease
...PET picking up metabolic signals of body cells and tissues and CT offering a detailed map of internal anatomy. "Our results must be confirmed by other investigators on a larger scale," said Hustinx, indicating that his team is currently conducting a study evaluating the capacity of PET/CT to assess early o...PET/CT: The best test for women with ovarian cancer
...said Fulham. Ovarian cancercancer that forms in tissues of the ovaryis the leading cause of death in women with gynecologic cancer, noted Fulham. In the United States, reports indicate that more than 22,000 new cases and more than 15,000 deaths attributed to ovarian cancer are expected this year. "Unfortu...A first: Simultaneous PET/MR images of the brain debut, increase molecular imaging capabilities
...tomy, functionality and biochemistry of the body's tissues and cells, enabling researchers to correlate MR an...e promise of allowing doctors to study which brain tissues might be salvageable after a stroke. PET imaging uses very small amounts of radioactive materials...Enzyme delivered in smaller package protects cells from radiation damage
...ion may have long-term negative effects on healthy tissues and organs, such as the kidney, liver and thyroid gland. Based on previous studies showing that intravenous gene therapy delivery of the enzyme manganese superoxide dismutase (MnSOD) could protect mice from whole body irradiation, and in preparati...Virus widely used in gene therapy research yields important clues to genomic instability
...s a powerful vehicle to deliver genes into various tissues in cells and animals, and these viruses, or vector...g DNA sequences on a whole genome scale in various tissues in living animals and human cells. "Our findings demonstrate that DNA palindromes of a modest size...