Bioengineer wins $500,000 engineering prize
...e led to fundamental advances in understanding how tissues interact with dynamic environments. Fung explained his insights and models in numerous papers and in the classic, enduring reference, Biomechanics: Mechanical Properties of Living Tissue (Springer Verlag, 1981), which is credited with improving vehic...How fish species suffer as a result of warmer waters
... induced deficiency in oxygen uptake and supply to tissues is the key factor limiting the stock size of a fish species under heat stress. Scientists of the Alfred Wegener Institute for Polar and Marine Research in Bremerhaven investigated the relationship between seasonal water temperature and population d...JCI table of contents: January 2, 2007
...estines, including our gut bacteria, access to our tissues and bloodstream; large numbers of bacteria in the ...f Ptgs2-expressing stromal cells in the intestinal tissues to sites in the epithelial cell layer rich in ColEPs. Further studies will be required to determine ...MIT creates 3-D scaffold for growing stem cells
...cive microenvironment for tissue cell cultures and tissues used in regenerative medicine, such as skin grafts...t better represent the natural context of cells in tissues and organs," said Zhang, whose coauthors on the paper, in addition to Gelain, are from institutes an...Profiling of cancer genes may lead to better and earlier detection
...45 of these new genes in both normal and cancerous tissues from the same patients and found that many of the genes were methylated specifically in the tumor samples. "We ended up with a large number of genes that are involved in the development of lung cancer that, despite years of work in the field, I ha...Complexity constrains evolution of human brain genes
...example, genes expressed only in male reproductive tissues have evolved very rapidly." Brains, however, "ar...himpanzee remain very similar, previous studies in tissues other than the brain have shown that gene expression varies widely. Other studies have found that, w...Dengue and other hemorrhagic fevers: Towards a first potential treatment
... they are involved in the reconfiguration of organ tissues during human embryonic development or tissue repair, but also in the development of certain cancers. They attack specifically the intercellular cement that binds the vascular walls. The research team demonstrated, in vitro, that Dengue-virus infectio......erapy is defined as the introduction of genes into tissues or cells via gene transfer, with the purpose of deriving a therapeutic or preventative benefit from the function of these genes. Gene transfer is achieved using a vector a kind of vehicle that carries the gene. Somatic gene transfer only targets bo...Treatments for urinary infections leave bacteria bald, happy and vulnerable
... will be unable to adhere to or invade the bladder tissues and are readily eliminated from the body." Pinkner and his colleagues think the bacteria will find it harder to evolve resistance to a treatment that does not directly impact their survival. According to an April 2006 National Institute of Allergy a...Abnormal proteins linked to schizophrenia found in body tissue
...ect similarly altered proteins in other organs and tissues of individuals living with the disease. After looking at thousands of proteins, they found that people with schizophrenia had 14 liver proteins and eight red blood cell proteins that were significantly altered compared to individuals who didn't have ...Researchers create genetically matched embryonic stem cells for transplantation
... to generate the stem cells, and concerns that the tissues derived from this special type of embryonic stem c...ls into MHC-matched mice, a variety of specialized tissues formed, with no rejection and no need to suppress the recipients' immune system. Daley's laboratory...UCSF stem cell study reveals cells' capability in mouse brain tissue repair
...that the cells behavior could be enhanced to treat tissues damaged throughout the brain by disorders such as stroke and traumatic injury. The study, reported in the December 15 issue of Cell, was led by Chay T. Kuo, MD, PhD, a UCSF postdoctoral fellow in the laboratory of senior investigator Yuh-Nung Jan, ...Forsyth scientists discover early key to regeneration
...tic regeneration in humans, potentially addressing tissues that are lost, damaged or non- functional as a res...e regeneration program. One possible model is that tissues normally contain a population of cells whose purpose is to prevent massive growth in the region surr...Phylonix awarded National Science Foundation Phase II SBIR for zebrafish screening
...f chemicals on the development of human organs and tissues using a panel of assays performed in zebrafish. "This award validates the importance of zebrafish as a predictive model for assessing toxic effects of environmental contaminants on mammalian development," commented Patricia McGrath, Phylonix Presid...News tips from the Journal of Neuroscience
...empts at recovery through neuronal regeneration in tissues near the infarct, according to two separate studies published this week. Using histological analyses in a large collection of postmortem human brains, Macas et al. found increased numbers of neuronal precursor cells, even in patients of advanced age ...Burnham Institute for Medical Research announces affiliation with UC Santa Barbara
...ls ("vasculature") that are specific to individual tissues and disease sites. Ruoslahti has discovered ways to selectively target drugs to tumor blood vessels in mice and suppress the growth of those tumors. He has also found a way to selectively target the lymphatic vessels in tumors. The hope is that this...A fisheye view of the deadliest breast cancer
...st cancer cells. Being transparent, the zebrafishs tissues gave them a window on live human cancer cells in action. The researchers were particularly interested in the small GTPase RhoC that is overexpressed in highly metastatic forms of breast cancer. Using various fluorescent tags, they labeled human MD...Stem cells found in adult hair follicles may provide alternative to embryonic stem cells
...stem cells generate a wide array of cell types and tissues and actually give rise to the autonomic and enteric nervous systems along with endocrine cells, bone and smooth muscle cells. The cells can be isolated from the hair follicle bulge as multipotent stem cells, and then expanded in culture into millions...Pittsburgh-based team engineers muscle, bone cell differentiation with aid of ink-jet printer
...ine could one day benefit millions of people whose tissues are damaged from a variety of conditions, includin...dy works: the body is one vessel in which multiple tissues are patterned and formed. The ink-jet printing technology allows us to precisely engineer multiple u...... system that can pattern the formation of multiple tissues from a single population of adult stem cells. B...ilities if researchers are to engineer replacement tissues that might be used in treating disease, trauma, or genetic abnormalities. Spatial patterning of stem...