Alzheimer's drug based on Purdue -- designed inhibitor begins clinical trials
...a beta-secretase inhibitor. "These molecules fit together like puzzle pieces," Ghosh said. "We created a molecule that fits with a key piece of the Alzheimer's disease puzzle. When the treatment molecule binds to the enzyme, it changes the shape of that puzzle piece so that it no longer fits in its original...New compound effectively treats fungal infections
...nslate the messenger RNA into protein by stitching together the amino acids in the order specified by the message. This requires the help of molecules called tRNAs, which link the code of the messenger RNA to the correct amino acid. Leucyl-tRNA synthetase is one of a group of enzymes called aminoacyl-tRNA sy...2 MSU professors spearhead international water project
...ce Foundation (NSF), the team leaders are bringing together domestic and international expertise, as well as investing in students, to develop water purifying strategies using what are called membrane-based technologies. Membrane-based technologies selectively remove things such as chemicals and particles f...Paving the way toward a vaccine against Alzheimer's disease
...protein clusters inside and outside the cells work together to destroy the cells. They already noticed that the clusters outside the cells affect those inside cells by making them grow. Another challenge will be to better understand what the clusters do inside the cells that leads to their death. The scientis...CSHL awarded Pre-College Science Education Grant by HHMI
...w research institutions and local schools can work together to increase science education opportunities. The Pre-college Science Education Initiative for Biomedical Research Institutions aims to encourage research institutions to use their unique resources to stimulate interest in science, according to Dr. ...Helping chlorine-eating bacteria clean up toxic waste
...omputer models of how the bacteria's proteins work together under each condition and whether the pathway for each condition is the same for PCE and TCE, and if not, what steps they have in common. It will be an "iterative process," Richardson said. If a model shows that changing a particular condition produ...UN issues analysis of global investors' sustainable energy 'gold rush'
...still mostly in OECD countries, with the US and EU together accounting for more than 70% in 2006. However, investment in developing countries is growing quickly: 21% of the global total in 2006 occurred in developing countries, compared with 15% in 2004; A healthy 9% of global investment occurred in Chin...Scientists ponder plant life on extrasolar Earthlike planets
... a dead world. The presence of methane and oxygen together on an extrasolar planet, for instance, would be a strong smoking gun for the possible existence of life. Life on the edge They also are looking into the red edge effect. Seen at 700 nanometers out, where normal human vision quits wor...Weizmann Institute scientists develop a general 'control switch' for protein activity
...zmann Institutes Biological Regulation Department, together with Dr. Miri Eisenstein of Chemical Research Support, have recently developed a unique switch that can control the activity of any protein, raising it several-fold or stopping it almost completely. The method provides researchers with a simple and e...Human genetic 'deserts' are teeming with significant life
...among the many international collaborators working together on a pilot project to use as a reference set by th...warming mass of different overlapping transcripts, together with our findings that suggest we have only uncovered a portion of its complexity, has important imp...UVa researchers restore genes in human inner ear cells
...nts are effective in human inner ear tissue. Taken together with the results from another group of scientists who showed that similar gene therapy compounds can produce new hair cells and restore hearing function in guinea pigs suggest that the future of gene therapy in the human inner ear is sound, Holt said...Louisiana Tech researchers help find new sub-atomic particle
...accurate models of how individual quarks are bound together into larger particles such as protons and neutrons."...Deprived bacteria grow up meaner
...ygen supplies. Bjarke Christensen and Tine Licht together with colleagues from Denmarks National Food Institute set out to investigate whether the growth conditions of Listeria bacteria just prior to being eaten had an effect on their virulence once absorbed by the gut. Guinea pigs were fed food laced with ...Research finds that circadian rhythms dominate all life functions
...ness, the groups of genes that typically oscillate together -- such as genes responsible for the function of an organ or a specific tissue -- are chaotic under this state and don't function as a group. Lack of orchestration can be easily confused with the lack of oscillation. This makes the rhythm much harder...St. Jude study yields secrets of chromosome movement
...divides. Centromeric heterochromatin helps to yoke together the sister chromatids of each chromosome pair as t...each chromosome pair is stable and securely linked together until its time to separate, said Janet Partridge, Ph.D., assistant member of the St. Jude Department...A possible mechanistic link between stress and the development of Alzheimer tangles
...their colleagues have been instrumental in piecing together a global view of how the corticotropin-releasing family of molecules regulate our bodies responses to physiological and emotional stress. Lee made available his mice that had been genetically engineered to lack either CRFR1 or CRFR2. And sure enoug...On the defense: Conserved features of plant innate immunity
...ia) and colleagues report that three proteins work together in the MOS4-associated complex (MAC) to execute innate immunity in the mustard weed, Arabidopsis. Dr. Li and colleagues study a plant autoimmune model in which a mutation in one immune receptor, SNC1, causes constitutive activation of the plant's ...Could fungal collection hold the key to new life-saving drugs?
... strains of infections such as MRSA. SIDR brings together scientists from different disciplines to focus on drug discovery. They have developed test systems to detect biological activity in samples of natural products that could lead to new medicinal products. Previous work at SIDR found activities from pla...New findings challenge established views on human genome
...ntify every part and understand how the parts work together to contribute to health and disease. In recent ...e collaborative study focused on 44 targets, which together cover about 1 percent of the human genome sequence, or about 30 million DNA base pairs. The targets ......and father is not enough to keep an avian marriage together for the Nazca booby, a long-lived seabird found in...y improves as the pairs of birds get older and are together longer, as has been found in other birds. But, often the female seeks a divorce after a few breedi...