Tag: "tolerated" at biology news

US researchers show cottonseed drug is cancer treatment booster

... has been extensively tested in humans and is well tolerated for long-term use. If we use the more active form,(-)-gossypol, correctly and wisely for example, in combination with radiation and/or chemotherapy gossypol may soon find its new role in our fight against cancer." Dr. Xu wishes to see the findings ...

Mice thrive despite massive genetic makeover

...e were found. "By and large, these deletions were tolerated and didn't result in any noticeable changes," said Nbrega. "An important caveat, however, is that no matter how detailed our analyses, our ability to test for a particular characteristic in mice is limited. All we know is that, in the time fram...

Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds

...ite of injection, it caused pain that was not well tolerated by the patients in the study. Sensory neurons throughout the body convey information about touch, pain, temperature and joint position to the spinal cord, which in turn transmits the information to the brain in order to register a particular sensati...

VYTORIN (TM) superior again to Lipitor at lowering LDL (bad) cholesterol

... 40 mg and 80 mg (p Study showed VYTORIN was well tolerated and had lower incidence of liver function elevatio...s than Lipitor Both VYTORIN and Lipitor were well tolerated in the study. The percentage of patients with clinical and laboratory adverse experiences was gener...

New pathway identified in angiogenesis

...t a tumor site, but it appears to be safe and well tolerated in the animals we've studied," says Marsh. The findings come at a time when new methods to thwart angiogenesis are sorely needed. So far, the small handful of drugs and targeted therapies engineered to block the process have had only lim...

FDA approves ABRAXANE(TM) for metastatic breast cancer

...ancer based on its superior response rate and well tolerated safety profile," said Joyce A. O'Shaughnessy, M.D....medication for hypersensitivity, ABRAXANE was well tolerated in the pivotal Phase III trial. Neutropenia (all grades) was experienced by 80% of patients treat...

Common virus becomes a new target for cancer treatment

... cells harboring the virus. The treatment was well tolerated in all but one patient, who had pre-existing facial swelling that increased after the infusion. "Radiation and chemotherapy, the traditional treatments for nasopharyngeal carcinoma, frequently fail and can cause severe long-term side effects," said ...

Study finds Seroquel effective and well tolerated

...gnitive function. SEROQUEL was also generally well tolerated with no incidence of cerebrovascular adverse events during treatment, which have been associated with the use of other atypical antipsychotics in this patient population. 1 In the 30-day follow up, one cerebrovascular event was reported in the 100 ...

'Color-blind' method opens new doors in DNA sequencing

... precision, and the number of mistakes that can be tolerated is extremely low," said Curl, University Professor, the Kenneth S. Pitzer-Schlumberger Professor of Natural Sciences and professor of chemistry. "Our new method does away with identification problems altogether, because the imaging is very clean." Me...

Two-part blood pressure control suggests new approach to hypertension therapy

...kidneys that lacked the receptors in other tissues tolerated dietary increases in salt and maintained blood pressures comparable to mice fed a normal diet. "These findings indicate that angiotensin receptors in the kidney have unique and non-redundant actions in blood pressure control," Coffman said. "However,...

Ophthalmologists implant five patients with artificial silicon retina microchip

...otoreceptor cells of the retina. If the implant is tolerated well and is able to successfully stimulate the retina, it may open up new opportunities for restoring sight in patients with the end stages of retinitis pigmentosa."...

MIT develops 'Anklebot' for stroke patients

...same time, the trial showed that the robot is well tolerated by patients and causes no pain. The new center at the Baltimore VA aims to "implement for the lower extremities what we did for the upper extremities," Krebs said. The MIT-Manus work also answered a longstanding question among therapists: manual mani...

Joslin-chaired study shows new compound may decrease vision loss in diabetes

...milligrams per day of ruboxistaurin (RBX) was well tolerated and may reduce the risk of moderate vision loss, especially in patients with diabetic macular edema. Loss of vision is a common complication of diabetes and results from two primary conditions: diabetic retinopathy and diabetic macular edema. In diab...

Carbon monoxide: Poison gas or anti-inflammatory drug?

...noxide is lethal at certain doses, but the animals tolerated the 100 ppm level for two weeks with no apparent problems," Pinsky says. "In human terms, it's equivalent to the amount you'd receive sitting in a traffic jam in Mexico City." The next step was to analyze the amount of Hmox enzyme expressed in white ...

Warming most evident at high latitudes, but greatest impact will be in tropics

...imals and insects to determine how the populations tolerated changing temperatures. Then they developed models based on the average between a region's highest temperature in the warmest month of the year and lowest temperature in the coldest month and programmed the region's expected temperature changes becaus...

Researchers propose measures to curb lion attacks in Tanzania

...s in pursuit of bush pigs, and some even said they tolerated lions because the big cats helped control bush pig numbers. Moving people away from areas prone to lion attacks is not feasible, the researchers report. Thus, pig-control strategies offer the best hope for reducing encounters between lions and people...

A new view of human-chimpanzee genome differences

...ucture between humans and chimps arose or might be tolerated because of important adaptations in the genes themselves." There are a few examples of such rapidly evolving duplicated genes, but these genes have not been systematically analyzed due to the difficulties in characterizing genes in these regions of ...

Other highlights in the September 7 JNCI

...an antisense oligonucleotide to clusterin, is well tolerated and reduces expression of clusterin--a protein that promotes cell survival--in prostate tumors. Contact: Papinder Rehncy, BC Cancer Agency, 604-877-6261, prehncy@bccancer.bc.ca Also in the September 7 JNCI: Recent Improvements in Prostate Cance...

Sitagliptin, a new investigational treatment for type 2 diabetes, may offer new hope for patients

...trol. [3] As a result, there is a need for better tolerated treatments that do not cause weight gain and produ...Laboratories, Rahway, NJ, USA. "The need for well tolerated therapies which achieve better glycaemic control than current therapies is well known and we are con...

Cytokinetics presents data on CK-1827452

...clinical trial is designed to identify the maximum tolerated dose of a 6-hour intravenous infusion of CK-1827452. The effect of CK-1827452 on the left ventricular function of these healthy volunteers will be evaluated using serial echocardiograms. The cross-over design of this clinical trial will ensure that...

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(Date:7/30/2014)... of America (ESA) has elected ten new Fellows of ... acknowledges outstanding contributions to entomology in one or more ... following Fellows will be recognized during Entomology 2014 -- ... November 16-19, 2014 in Portland, Oregon. , DR. ... Department of Plant, Soil and Entomological Sciences at the ...
(Date:7/30/2014)... Jackson Laboratory has received a pledge of $1 million ... name the Laboratory,s new Neurobehavioral Biometry Center. ... Center will enable the Laboratory to develop a greater ... the ultimate goal of accelerating the pace of research ... serve as a premier resource for the Laboratory and ...
(Date:7/30/2014)... changing climate threaten some of the world,s most ... establish seed collections to save the seeds in ... some genetic diversity., For decades, these seed collections ... a one-size-fits-all approach for how many seeds to ... regardless of species, pollination mode, growth habitat and ...
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