Tag: "toxicity" at biology news

FSU scientist links iron imbalance to Parkinson's disease

... The study confirms that both iron deficiency and toxicity are linked to the specific genes and neuronal suic...age is set or slow the degenerative progress, iron toxicity both precipitates Parkinson's symptoms and hastens decline and death in existing victims. U...

New method studies living bacterial cells

...promoted tolerance to the chromium and reduced its toxicity level. Finally, when the cells made the transition from the planktonic state to the biofilm state, the scientists observed changes in the concentrations of many transition metals required for bacterial life. These results suggest that X-ray fluoresc...

IC-medtech licenses promising cancer therapeutic from Summa Health System

...ractical version of the chemo-adjunct based on low toxicity compounds to improve safety has been developed for use in clinical trials which are already underway. The treatment can be administered by intravenously (through a vein), intraperitoneally (through abdomen) or orally and it has been shown to enhance...

Genetically endowed worm may substitute for rodents in some toxicology testing

...feasibility of such a "high-throughput" C. elegans toxicity testing system that will use robotic equipment to mix chemicals and sort worms efficiently. During this evaluation, his group plans to expose developing roundworms to 200 different chemicals, in collaboration with researchers at the NTP and Envi...

Trojan-horse therapy blocks buildup of Alzheimer's plaque

...e Trojan horse molecules substantially reduced the toxicity of the amyloid by inhibiting growth of the shorter, more toxic chains of the amyloid plaque. With a second round of optimization, the scientists achieved even better results "In fact," said Crabtree, "we achieved much better protective effects than ...

Other highlights in the November 3 JNCI

...on beta, have limited utility because of excessive toxicity when delivered systemically. In a new study, Michael Andreeff, M.D., Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues demonstrated in a mouse model that mesenchymal stem cells, which are derived from bone marr...

Stanford environmental molecular science institute will study pollutants, one molecule at a time

...l compound is crucial to determining its potential toxicity and the degree to which it can be absorbed in the body, he added. ''For example, methylmercury in tuna is highly toxic and readily absorbed in human tissue, but solid mercuric sulfide is highly insoluble and does not pose as much of an environmental ...

UNC Lineberger researchers identify molecular markers of aging

...ability of a patient's bone marrow, predict future toxicity of chemotherapy in a cancer patient. Both p16INK4a and ARF are known potent tumor suppressors, or proteins that halt tumor cell growth. The study suggests that the important anti-cancer function of these proteins to limit cellular...

Automated scans let scientists track drugs' broad effects on cells

...ghly relevant to understanding the specificity and toxicity of drugs," says Altschuler, research fellow at the Bauer Center for Genomics Research in Harvard's Faculty of Arts and Sciences. "The information gleaned includes many key indicators of drugs' potential usefulness and limitations as medicines." "We...

New studies regarding the efficacy of antioxidants and their impact on standard cancer treatment

...ey improve the efficacy of treatment by mitigating toxicity and side effects. The December 2004 issue of the ... potential radioprotective agent with little or no toxicity that was developed from the fruit of Aegle marmelos (AME) (Ganesh Chandra Jagetia, Ponemone Venkates...

Tips from the Journals of the American Society for Microbiology

...he lifecycle of the smallpox virus and have little toxicity to human cells. They report on this new antiviral drug candidate in the November issue of the Journal of Virology. An outbreak of the smallpox virus is considered to be one of the greatest threats facing the world today. No antiviral drug has proven...

Columbia researchers identify drug as therapeutic candidate for spinal muscular atrophy

...ction, to deliver the drug to the spinal cord, and toxicity testing of related drug molecules. A clinical trial for its effectiveness in treating SMA could follow. It should be noted that the researchers found that ibuprofen and other nonsteroidal anti-inflammatory drugs had no effect on increasing the produc...

Stronger therapy better for AML with normal genetics

...tive but has fewer side effects, which can include toxicity to the kidneys and brain. "This has been suspected, but it hasn't been carefully studied," Farag says. "Again, we need a larger randomized study in the future to verify this, but our data show that we don't need to push the dose to the m...

New drug sidesteps Gleevec resistance in human trials

.... Phase I clinical trials evaluate drug safety and toxicity at different dose levels in a small number of volunteers. "Our study examined patients in all phases of CML, including the chronic phase, the accelerated phase, and blast crisis. The patients responded quite well to this new compound, and we observed...

Science to restore the nation's ecosystems

...er the Everglades restoration could affect mercury toxicity in the future. Sulfur Contamination in the Florida Everglades: Where Does It Come From, What Is Its Extent, What Are Its Impacts, and What Can We Do About It? , W. Orem, USGS, Reston, VA, 11:00-11:15am, Location: Cloister. Sulfur contamination re...

Nanotubes glow, even within biological cells

...tor elements. Although long term studies on toxicity and biodistributions must be completed before nano...tudies, particularly in cases where the bleaching, toxicity and degradation of more traditional markers are problematic. ...

Study in Royal Society journal on first evidence for magnetic field detection in sharks

...hat this cheating strategy of avoiding the cost of toxicity but cashing in on the protection should destabilise warning coloration. We offer a solution, and show that birds offered a mixture of nasty prey and mimics can "sample-and-reject" the truly nasty prey, leaving them relatively unharmed, and eating onl...

JCI table of contents, December 15 2004

...motherapy who suffer from bleeding due to platelet toxicity are regularly transfused with large numbers of platelets from healthy donors." Leading us to question "[is] this life-saving therapysimultaneously facilitating metastasis of their cancerous cells?" Gutpa and Massagu stress that any effective therapie...

Yo-yo diet redistributes toxins in body tissue; Olestra+caloric cut boosts toxic excretion

...y of Western Australia, treated a patient with PCB toxicity over a two-year period with olestra in the form of fat-free Pringles. The patient's chloracne disappeared and the PCB level in fat tissue dropped dramatically. The same University of Cincinnati School of Medicine team is reporting new research that ...

JCI table of contents, 3 January 2005

...phoblastic leukemia are more prone to methotrexate toxicity Methotrexate (MTX) is a chemotherapy drug widely used to treat childhood acute lymphoblastic leukemia (ALL) by interfering with folic acid activation and preventing cell reproduction. However, the formation and accumulation of MTX polyglutamates (MT...

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