Clues to the puzzle of 'talking' root cells
...t of the protein, Benfey and his colleagues used a tracer molecule that enabled them to pinpoint the Short-R...ssociated with any molecular complex. However, the tracer did not reveal that the protein was moving from one cell to another. The researchers also f...Evidence that learning is consolidated during sleep
...active tracer, and their brains are scanned as the tracer infuses through the brain. Blood flow through specific brain structures constitutes a measure of activity in that structure. The researchers found that the first group -- compared to the non-trained group -- showed greater activity in their hippocamp...New nicotine-like imaging agent holds promise in PET studies, may help diagnose Alzheimer's disease
...with animal subjects must be completed before this tracer can be used to demonstrate applications in human studies, said the co-author of "Synthesis and Evaluation of Nicotine α 4 β 2 Receptor Radioligand, 5-(3'-18F-Fluoropropyl)-3-(2-(S)- Pyrrolidinylmethoxy) Pyridine, in Rodents and PET in Nonh...PET/MRI scans may help unravel mechanisms of prenatal drug damage
...er extent in the brain. "While the uptake of the tracer into the fetal brain is lower and slower than in the mother's brain, a measurable quantity of cocaine and/or its labeled metabolites does accumulate in the fetal brain, particularly in the striatum, where cocaine is known to bind to cell-surface rece...Brain-mapping technique aids understanding of sleep, wakefulness
...euron receives signals. Researchers then track the tracer to map the upstream neurons. Dr. Yanagisawa and h...udy a specific neural pathway. They introduced the tracer into mice so that it was expressed only in orexin neurons, which are found in a part of the brain ca...Brain scans reveal how gene may boost schizophrenia risk
...king memory tasks. The second scan used a dopamine tracer to reveal the synthesis of the neurotransmitter in the midbrain. Frontal cortex activity increased as midbrain dopamine activity increased in subjects with val, but decreased in those who had inherited two copies of the met COMT gene. This "trait-...Use of PET can reduce, may eliminate more strenuous drug development trials with animals
... biology of a person's body by monitoring ingested tracer molecules, and it is used to study the metabolism ...partment of nuclear medicine and the department of tracer kinetics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan; SNM member Yuji Kuge, Ph...How monarch butterflies are wired for navigation
...egion called the dorsolateral protocerebrum. Using tracer molecules, they were surprised to discover tiny neural fibers containing a key clock protein that connected with the polarization photoreceptors in the butterfly eye. "This pathway has not been described in any other insect, and it may be a hallmark ...Positive effects of nuclear medicine, 'smart drugs' provide hope for non-hodgkin's lymphoma patients
...w offered a choice of "months of chemotherapy or a tracer and treatment dose given over about a week," said Wahl. Results are even more promising using tositumomab and iodine-131 tositumomab earlier in the course of the illness before many chemotherapies have failed. "Efficacy by Treatment Course Following ...Scientists test the potential of integrated PET/CT for molecular imaging of the heart
... single PET/CT imaging session, recently developed tracer techniques--which target the expression of genes that are transferred to the heart muscle and the expression of proteins involved in the growth of new blood vessels--were combined with techniques for measuring blood flow to the heart and for imaging ...A national plan for the R&D needed to protect U.S. critical infrastructure is released
...ld be anything from new explosives that release no tracer chemicals, new toxins so unusual that we have no data as yet on them, or new software viruses that arrive in pieces and self assemble later), the Plan asks the critical question of "how well we can anticipate these threats," and outlines research dir...A picture of progress: PET imaging and biomarkers explored at ACS meeting
...sburgh recently developed Pittsburgh compound B a tracer molecule that highlights beta-amyloid, a telltale Alzheimer protein, in a positron emission tomography (PET) brain scan. The team has launched a 10-year population study to track beta-amyloid development in the brains of aging seniors. The researcher...Smoking damages key regulatory enzyme in the lung
...hows that smokers had a lower concentration of the tracer in the bloodstream than nonsmokers did, leading to... positron emission tomography (PET) scanning and a tracer chemical that binds to a specific form of the enzyme monoamine oxidase (MAO A) to track MAO A levels...Microfossils show promise in prospecting climate history
... in the back barrier marshes. We used fossils as a tracer to prove the mode of deposition." The foraminifera that Hippensteel found in the deposits include modern off-shore species and also species that were know to live off-shore in the Oligo-Miocene period (25-30 million years ago) and are known to be pre...The brain is broadly wired for reproduction
...n which GnRH neurons produce barley lectin (BL), a tracer molecule that travels upstream and downstream to connected neurons, and green fluorescent protein (GFP), to mark the producing cells. By visualizing the locations of BL, GFP, and GnRH neurons and their axons, the researchers were able to identify neu...Olfactory system detects pheromones that control reproduction
...essing LHRH provided that signal, making the viral tracer highly specific. "So, whenever we saw a signal from the conditional virus, we knew we were seeing connections to neurons expressing LHRH and nothing else," said Dulac. As a control, the researchers also used a "non-conditional" strain of pseudorabies...SNM awards $25,000 Mallinckrodt Seed Grant in Molecular Imaging/Nuclear Medicine Research
...te of Atomic Energy. Yu has been involved with PET tracer development for more than 10 years and has experience in PET data processing, including modeling calculation....SNM provides $75,000 in 2005 grants, awards for molecular imaging/nuclear medicine researchers
...te of Atomic Energy. Yu has been involved with PET tracer development for more than 10 years and has experience in PET data processing, including modeling calculation. The ERF funded the William L. Ashburn, M.D., Pilot Research Grant, which is funded by Digirad Corporation in memory of the co-founder of the...JCI table of contents, March 16, 2006
...d retention of cholesterol in the intestine. These tracer studies suggest that uptake of cholesterol from the intestine is not affected in ABCA1 knockout mice, but that transport of absorbed cholesterol into the blood is dramatically impaired. Together these data demonstrate that intestinal ABCA1 is a major...Brookhaven Lab and Mount Sinai form joint Center for Translational Biomedical Imaging
... specialized facilities for the development of new tracer molecules. This agreement draws on the complimentary strengths of our two institutions," said Fritz Henn, Brookhaven Lab's new Associate Laboratory Director for Life Sciences. "Our hope is that this center will foster innovations in radiotracer deve...