Large-scale genomics project will hunt genes behind common childhood diseases
... interact with environmental factors. "We will be tracing the major underlying genetic component of disease-related genes while discovering the biological pathways involved in disease development," Dr. Hakonarson added. "For instance, a specific cholesterol receptor may be dysregulated because of genetics, ...Salk research challenges concept that motion perception is all black and white
... really pioneering the use of trans-synaptic viral tracing to study the visual system. Already, with our first study and experiments, we're having to rethink how the visual system is wired-up." Part of the reason why scientists had overlooked this circuit was because the M pathway is known to be more sensit...News Tips from The Journal of Neuroscience
... capsaicin to induce hyperalgesia. Transganglionic tracing of the capsaicin injection site marked the nonpept... capsaicin to induce hyperalgesia. Transganglionic tracing of the capsaicin injection site marked the nonpeptidergic class of nociceptors, but not peptidergic ...MSU researchers shake out basis for rice domestication
...y, yet delivered accurate results," Sang said. "By tracing the breeding of rice and identifying the genetic mutations, the researchers have opened new doors to the science community that benefit the world through a more effective use of the land and water used to grow rice," said Rich Triemer, chairperson of......he many controlling currents inside sperm and also tracing how calcium triggers hyperactivation once it enters the cell. Such studies will enable exploration of sperm machinery from tail to head analyzing processes ranging from tail motility to the mechanism by which the sperm head delivers its genetic payl...Missing steps of jumping-gene replication discovered
...ertions included small pieces of extra DNA. While tracing the origin of this extra DNA, Daria Babushok, an MD/PhD student in the Kazazian lab, came up with the missing steps in the mechanism of retrotransposon replication. "It was known previously that the enzyme endonuclease cleaves one of the strands of c...Utah researchers confirm chromosome may harbor autism gene
...rs at the U School of Medicine made the finding by tracing variations in the DNA of an extended Utah family that has a high occurrence of the disorder and whose members are descended from one couple. As part of the study, the researchers also ruled out one gene that appeared to be a good candidate for being ...Light-sensing cells in retina develop before vision
... study the cells, requiring precise injection of a tracing dye into the brains of animals to label and identify the ipRGCs. That has changed as the result of a technical advance developed by Daniel C. Tu and Donald Zhang, both Medical Scientist Training Program students in Van Gelder's lab, and co-first aut...Zeroing in on progeria: How mutant lamins cause premature aging
... progeria researchers made a breakthrough in 2003, tracing HGPS to a spontaneous mutation in a gene encoding an important structural component of the cell nucleus, the organelle in which our DNA is stored, read out, and copied. As the so-called "Mothership of the Human Genome," the cell nucleus must keep all...Olfactory system detects pheromones that control reproduction
...omonal cues on LHRH release. But because classical tracing techniques could not specifically identify the connection of neuronal subsets, they ended up tracing the routes of groups of undefined neuronal populations clustered around LHRH producing neurons, Dula...The brain is broadly wired for reproduction
... The scientists began their studies by focusing on tracing the neural pathways leading to and from neurons th...lving GnRH neurons, the researchers used a genetic tracing method that they previously developed for charting neural pathways. They first engineered mice in wh...Rutgers' Wise Young named to Esquire's 'Best and Brightest of 2005'
...quire takes five pages to tell Wise Young's story, tracing his history from mid-century Hong Kong and Japan, through Reed College, Woods Hole and New York University, to his tenure at Rutgers. The article details his accomplishments in medicine and chronicles the evolution of his unflagging dedication to cur...Neural stem cells are long-lived
...n to use their technique of marking stem cells and tracing their fate to explore their role in repairing injured brain tissue in animal models. Such studies, she said, could reveal whether growth factors that influence stem cell growth could be used to treat brain injuries. "If these stem cells do produce ce...JCI table of contents October 3, 2005
...ribe studies using a new method they developed for tracing macrophage to feces RCT to address the question of whether liver expression SR-BI regulates the rate of RCT. The authors show that liver SR-BI expression is a positive regulator of macrophage RCT. Mice overexpressing SR-BI efficiently clear choleste...Transmission of tuberculosis is linked to historical patterns of human migration
...these observations have important implications for tracing the evolutionary history of microorganisms. "The timing of hallmark changes in bacterial genomes within the last 100,000 years may be inferred from comparison with relevant human migrations," he says....'Underground' tunnels discovered as means for communication between immune system cells
...may be conceivable to follow the entire pathway by tracing the network of tunneling nanotubules," said Dr. Salter. The authors' discovery builds on their recent research showing how dendritic cells respond to stimuli, but, as they freely admit in this paper, it was due in large part to an accidental observat...Analysis of flower genes reveals the fate of an ancient gene duplication
...haped the evolution of today's living species, but tracing the evolution of a specific single gene over millions of years of evolution--and over potentially several gene-duplication events--can pose a significant challenge. One way in which this can be overcome is for researchers studying a particular modern...Understanding Fragile X syndrome with the blink of an eye
...fect underlying Fragile X syndrome, they are still tracing how that defect creates the complex mix of mental retardation, hyperactive behavior, attention deficits, and other problems in the disorder. Fragile X is particularly important because it is the most common single-gene cause of mental retardation--af...Understanding biases in epidemic models important when making public health predictions
...uate levels of disease management, such as contact tracing and quarantining of those exposed. However, Wearing was careful to stress that current health protection programs have shown their effectiveness in such situations as the recent SARS outbreak in Southeast Asia. "We are highlighting what 'may happen'......lldobler explore the evolutionary history of ants, tracing their waves of expansion from the first appearance more than 100 million years ago. Over the past two decades, fossil discoveries combined with studies of anatomy, behavior, and DNA have helped clarify the phylogeny of ants, the authors say. Yet some...