Tag: "transcripts" at biology news
Unravelling new complexity in the genome
...fy multiple protein products by processing the RNA transcripts
made from genes (which are translated to make protein). We are finding that a significant number of genes operating in the same biological processes and pathways are regulated by alternative splicing differently in nervous system tissues compared...
New findings challenge established views on human genome
...o functional molecules, called RNA, and that these transcripts
extensively overlap one another. This broad pattern of transcription challenges the long-standing view that the human genome consists of a relatively small set of discrete genes, along with a vast amount of so-called junk DNA that is not biologically...
ENCODE map changes view of the human genome landscape
...ey found that more than half of the genes produced transcripts
that contained sequences mapping outside of the kn...7-927. (doi:10.1101/gr.6081407) 5. Classified transcripts
The ENCODE Project produced an enormous amount of data on transcriptionally active regions (TARs)...
New findings challenge established views about human genome
...f human DNA is transcribed into RNA and that these transcripts
extensively overlap one another. This broad patter... investigated as part of the ENCODE effort how RNA transcripts
are processed in human cells. In the 27 March issue of PNAS they reported that alternative splicing,...
The wider view from a detailed focus
...NA is pervasive across the genome, and that RNA transcripts
overlap known genes and are found in what were pre...ed. The role of the massive new numbers of RNA transcripts
is unknown. And the function of the large number of control elements is yet to be elucidated. ...
Almac Diagnostics announces pioneering genetic research on colorectal pre-malignancies
... in the human RefSeq database 26,676 (51%) of transcripts
are not present in the human RefSeq database 7% of the content represents expressed antisense transcripts
to annotated genes To date, Almac Diagnostics has launched Colorectal Cancer DSA and Breast Canc...
News tips from the Journal of Neuroscience
...iption-PCR that the bulk of L-type calcium channel transcripts
in granule cells encoded Ca v 1.2 subunits, whereas the remainder encoded Ca v 1.3. Single-channel recording from granule cells in Ca v 1.3 -/- mice revealed normal amounts of both gating types. In Ca v 1.2DHP -/- mice, which express mutant Ca v 1...
Whole body regeneration from a blood vessel
...ting RA synthesis with chemicals and destroying RA transcripts
with RNA interference. In both cases, malformed buds failed to generate zooids from dissected fragments. Similar problems occurred when RAR function was disrupted. In contrast, RA overexpression led to accelerated regeneration, with multiple buds rea...
Central and peripheral signals set the circadian liver clock
...n tissue from transgenic mice lacking Bmal1, mPer2 transcripts
in SCN neurons are barely noticeable during the course of a day. Its possible that mPer2 transcription is more dependent on BMAL1 in the SCN than it is in the liver, however the authors considered two other explanations for the observed mPer2 acti...
How many genes does it take to learn? Lessons from sea slugs
...have assembled a tremendous amount of data on gene transcripts
associated with neuronal signaling pathways in Aplysia that sheds new light on evolutionary relationships of this very ancient and highly successful marine animal," said Dennis Steindler, Ph.D., executive director of UF's McKnight Brain Institute, wh...
MIT: Engineered yeast speeds ethanol production
...produce desirable traits. "It is the makeup of the transcripts
that determines how a cell is going to behave and this is controlled by the transcription factors in the cell," according to Stephanopoulos, a co-author on the paper. The MIT researchers are the first to use this new approach, which is akin to alter...
Scientists discover role for dueling RNAs
...genomes by measuring the sense RNA, with antisense transcripts
thought to have no meaning at all," says Fink. "He...n fact, considering how widespread these antisense transcripts
are, I wouldn't be surprised if these findings eventually lead us to discover an entirely new level ...
RNA map provides first comprehensive understanding of alternative splicing
...Jernej Ule and Giovanni Stefani, took these 50 RNA transcripts
and searched them for clusters of sequences they h...whether it could predict how Nova would act on RNA transcripts
that had yet to be discovered. They took a bioinformatics approach, using a database of all alternat...
16 outstanding researchers receive Singapore's highest honor in science and technology
...he unique capability of identifying unconventional transcripts
derived from trans-splicing and chromosomal rearrangements. Leveraging on this new capability, the team invented the ChIP-PET (chromatin immuno-precipitation coupled with paired-end ditagging) analysis method for highly accurate, robust and unbiased...
Animals resistant to drunken behavior offer clues to alcoholism's roots
...lcohol. The distinct behavioral effects of the two transcripts
are mediated by RhoGAP18B function in the same subset of adult neurons, they reported. "Curiously, different RhoGAP18B transcripts, RA and RC, regulate the stimulant and sedating effects of ethanol, respectively," the researchers said. While the ex...
After insects attack, plants bunker sugars for later regrowth
...tial RNA display method, they found remarkably few transcripts
(mRNA) of GAL83 in the leaves attacked by insects. With the help of transgenic tobacco plants with constantly downregulated GAL83, they measured the same effect as in the nontransgenic, larvae-infested plants: the increased transport of carbon into t...
The Center of Nutrigenomics of the TU Munich licences Genomatix Microarray Analysis Pipeline
...hances the identification of significantly changed transcripts
and facilitates the generation of the full biological network of involved genes, and allows for functional analysis of the sub-networks most relevant for the experimental set-up. Downstream analysis looks for common promoter organization being respon...
MicroRNA processing and cancer
...y expressed in the nucleus as part of long primary transcripts
called primary miRNAs (pri-miRNAs). Inside the nucleus, pri-miRNAs are partially digested by the enzyme Drosha, to form -70 nucleotide-long hairpin precursor miRNA (pre-miRNA) that is exported to the cytoplasm for further processing by into shorter, ...
miRNA-mediated silencing of mRNAs
...rgonaute-1 protein in the miRNA pathway, targeting transcripts
for decay via a deadenylation and decapping reaction. The question of whether miRNAs silence gene expression without affecting mRNA levels has been controversial, and conflicting results have been reported in the literature. Dr. Izaurralde explain...
Creating new insight into HIV-AIDS virus wins Canada's top student biotech prize
...ced stages of HIV-AIDS infection. By examining RNA transcripts
of particular T-cells, James found that a protein molecule called CD127 was preventing the delivery of a "survival signal" by a hormone called interleukin-7, which is needed for the development, survival and proliferation of T-cells. "Now that we hav...
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