Tag: "transforming" at biology news

Modeling head and neck cancers

...ain of mice to specifically lack expression of the transforming growth factor beta receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either H-ras or K-ras (two different isoforms of the Ras GTPase), the researchers were able to induce invasive HNSCC with 100...

OHSU researcher develops first animal model to treat devasting head and neck cancers

...ain of mice to specifically lack expression of the transforming growth factor beta receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either the H-ras or K-ras (two different isoforms of the Ras GTPase), the researchers were able to induce invasive HNSCC with...

International support for Swedish stem cell research

...ues in their laboratory, with the ultimate goal of transforming human embryonic stem cells into insulin-secreting beta cells. Dr. Cecilia Anneren from Karolinska Institute will investigate the mechanisms that allow human embryonic stem cells to readily multiply while remaining in an "undifferentiated" state...

Alejandro Zaffaroni to receive 2006 Biotechnology Heritage Award

...oid research. He subsequently played a key role in transforming Syntex into a major pharmaceutical company that pioneered the development of the birth control pill. Zaffaroni developed controlled drug delivery technology, more commonly known as "the patch," and founded ALZA Corporation to bring this important tec...

Economic benefit of NINDS-supported clinical trials estimated at more than $15 billion

...s A. Zerhouni, M.D., Director of the NIH. "We are transforming the practice of medicine by moving into an era when treatment will increasingly become more predictive, personalized, and preemptive." "This study strongly suggests that, for this institute at least, the economic benefit from clinical trials more tha...

HHMI's experiment in changing scientific culture

...d the development and application of new tools for transforming the study of biology and medicine. With the opening of Janelia Farm in October 2006, Rubin will head HHMI's efforts to begin shifting the conservative balance prevalent in today's academic research centers by providing an environment where leading s...

The 100 greatest advances in medicine

...a time when healthcare management corporations are transforming the once intimate doctor-patient relationship into an impersonal provider-customer transaction, it is increasingly difficult for both doctors and the public at large to view medicine as an idealistic calling devoted solely to healing the sick. Yet th...

Blood pressure medication may revolutionize treatment of Marfan syndrome

...ivity of a pervasive developmental molecule called transforming growth factor beta. In a sea change in thinking ab...disease, researchers have recently discovered that transforming growth factor beta -- not simply a defect in a structural protein -- is most likely responsible for ...

Oxidation defense in mosquitoes benefits malaria parasite

...cribed in the PNAS article is responsible for this transforming of 3-HK into XA in the malaria vector Anopheles gambiae, where XA also helps the malarial parasite reproduce. So stopping the oxidative defense could stop the parasite as well as make the insect a victim of oxidative stress. Rizzi's group at the Univ...

The Amazon in 2050: Implementing the law could save a million square kilometers of rainforest

Economic and political forces are rapidly transforming the forests of the Amazon basin, precipitating one of the world's greatest environmental crises. Through an inter-discplinary modeling project known as Amazon Scenarios, scientists at the Woods Hole Research Center, the Universidade Federal de Minas...

Strawberries by design

... who has developed highly efficient techniques for transforming apple, remarked: "The commercial strawberry familiar to most consumers is octoploid, which means that it contains eight sets of chromosomes. By using a close relative that has two sets of chromosomes and a significantly smaller genome, the researcher...

Common molecular 'signature' identified in solid tumors

...g the tumor suppressors retinoblastoma-1 (RB1) and transforming growth factor, beta receptor 2 (TGFBR2). Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe we can prevent some of the very earliest c...

Birth defect gene identified

...haped heads. Chai's group focused on a gene called transforming growth factor-beta. TGF-beta is known to play an important role in human andanimal development. To study the gene's effect on the skull, the researchers deletedTGF-beta in mice embryos, but only in the cranial neural crestcells that build facial bone...

Bone quality regulator identified, suggests drug target

...onent of bone, is regulated by a molecule known as transforming growth factor beta. The finding, they say, suggest...y. In the current study, the team explored whether transforming growth factor beta (TGF-) regulates the properties of bone matrix because there were hints that it m...

Unexpected link between gene in liver and iron overload

... of a critical cell signaling pathway known as the transforming growth factor (TGF-) superfamily, SMAD 4 plays many central roles in development. Earlier studies had also linked abnormalities in SMAD4 to multiple forms of cancer. For example, mutations in the tumor suppressor gene are frequently detected in panc...

Protein marker associated with positive outcome in invasive breast cancer

...rook and Women's College Health Sciences Centre is transforming health care through the dedication of its more than 10,000 staff members and volunteers. Specializing in women's health programs, caring for Canada's war veterans, conducting leading-edge research, and teaching the latest advances in healthcare thro...

Sudden change in social status triggers genetic response in male fish, study finds

...rab subordinate male cichlid will begin physically transforming into a colorful dominant male as soon as he notice...get bigger, they crank out more and more hormones, transforming the male from doormat to dominant within 10 minutes. In fact, laboratory analysis confirmed that ...

Inherited gene change also found in spontaneous tumors

...rugs. The research focused on the gene for type 1 transforming growth factor-beta receptor, or TGFBR1, and on a v...nsights into the effects of the signaling molecule transforming growth factor beta. Transforming growth factor beta normally slows the growth of cells known as epit...

University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate

...rm, methoprene causes it to grow larger instead of transforming into a moth, enhancing the pest's ability to devastate crops. "It's not a great way to sell an insecticide to a farmer," Schooley said. "Most money in pesticide development is in making insecticides for pests which attack crops." This is what lead S...

New method shows it is possible to grow bone for grafts within a patient's body

...ent cells which, like marrow cells, are capable of transforming into the different types of skeletal tissue. So Shastri and his collaborators decided to create the bioreactor space just under this outer layer. They created the space by making a tiny hole in the periosteum and injecting saline water underneath. T...

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(Date:4/17/2014)... Double-stapled peptide inhibits RSV infection , Respiratory ... lower respiratory tract infections, generating life-threating illness in ... preventive therapies are limited. RSV enters host cells ... a six-helix fusogenic bundle. Small interfering peptides that ... however, these peptides are highly susceptible to degradation. ...
(Date:4/17/2014)... development of stem cell therapies to cure a variety ... cell populations based on cell surface markers. Researchers from ... that is highly expressed in a type of stem ... describe in an article in BioResearch Open Access ... publishers. The article is available free on the ...
(Date:4/17/2014)... that fish consumption advisories for expecting mothers are ... like persistent organic pollutants (POPs). , The ... University of Toronto Scarborough PhD student Matt Binnington ... levels of environmental contamination, a mother,s compliance with ... body influenced exposure in her children. , Their ...
Breaking Biology News(10 mins):JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6Fish consumption advisories fail to cover all types of contaminants 2
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