Tag: "transgenic" at biology news
Anti-cholesterol drug treats Alzheimer's disease in mice
...mer pellets under the skin of both normal mice and transgenic
animals engineered to have the human form of the aberrant protein that leads to A peptide. Such transgenic
mice develop the hallmark pathology of Alzheimer's, including brain amyloid plaque and memory defici...
Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
...d Regeneron Pharmaceuticals in Tarrytown, NY, used transgenic
(genetically altered) mice to study the biochemica...The investigators created two different strains of transgenic
mice--MIKK mice, in which NF-kB was activated selectively in muscle tissue, and MISR mice, in which ...
How to use math and a CT scanner to see how trees intercept light
... researchers) to assess the impact of a variety of transgenic
cotton on butterfly populations. The CT scanning facility that he co-ordinated the creation and start-up of provide researchers in plant, soil and animal sciences with an amazing tool for pioneering research in these areas....
Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...rairie voles. (1 pm 2 pm.) used gene therapy and transgenic
rodent models to demonstrate that activation of th...illustrates the importance of the gene therapy and transgenic
technology as effective and innovative tools for investigating the behavioral effects of gene expres...
Genetically endowed worm may substitute for rodents in some toxicology testing
... Another variation is to create varieties of transgenic
worm lines, each bearing a different gene that flu...l plate each well would have a different strain of transgenic
worm that could respond to a chemical," he said. "So you just put the same chemical in all the wells...
Research confirms that vCJD prions can be removed from blood
...with about 108 infectious units of human vCJD from transgenic
mice. The concentration of infectious vCJD prions in the red cell concentrates was measured before and after filtration with the Pall Leukotrap Prion Affinity Reduction Filter using a Western blot assay. The research with infectious scrapie prions...
Genetically engineered corn poses no immediate threat to Mexican crops
... group two years studying the potential effects of transgenic
or GM corn in Mexico. Concerns over gene flow from transgenic
corn to native Mexican varieties prompted the report, released today, called "Maize and biodiversity...
Army-funded effort examines androgen's role in bone loss
...she describes her research team's development of a transgenic
mouse group with overexpressed androgen receptors in bone-forming osteoblast cells. "There's a whole superfamily of receptors for steroid hormones; steroids require a receptor for biologic actions," Wiren said. "By overexpressing the rece...
Potent anticancer drug increases function of axons in mouse model of neurodegeneration
...n Trojanowski's and Lee's laboratory, gave the tau transgenic
mice weekly injections of Paxceed at a high and lo...The drugs also reduced motor impairment in the tau transgenic
mice. Because microtubule-binding drugs such as Paxceed are approved for treating patients with canc...
Blocking cell suicide switch fails to stop prion damage in mouse brains
... killing off a class of important brain cells in a transgenic
mouse model. But when they found a way to rescue those cells, they were astonished to discover the mice still became sick. Now they believe previous efforts to find the beginnings of the mouse disorder may have been focused on the wrong part of the b...
The Louis-Jeantet-Prize for Medicine 2005
...d language development. To this end he will create transgenic
mice that carry either the human or chimpanzee version of the gene. Svante Pääbo plans to recruit two new collaborators to his project. The Louis-Jeantet Foundation for Medicine The Louis-Jeantet Foundation for medicine was established ac...
Fat deficiency gene also spurs obesity
... elucidate lipin's role, the researchers generated transgenic
mice with enhanced expression of the gene in either mature fat cells or skeletal muscle. When fed a high-fat diet for a period of six weeks, mice with elevated lipin in fat or muscle showed accelerated weight gain, with a 20 percent greater increase ...
Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
...epair of these lesions. The researchers found that transgenic
mice bearing the CPD photolyase transgene, in cont...s of UV irradiation. Not only could CPD photolyase transgenic
animals withstand doses of UV light that cause severe sunburn in normal mice, but they also showed s...
What does an airline traveler have in common with a glowing fish?
...sh circadian gene period3 (per3). Each cell of the transgenic
fish has one normal copy of the per3 gene and one ...rotein. Kaneko and Cahill anticipate that these transgenic
zebrafish will be quite useful in examining the molecular machinery of the vertebrate circadian cloc...
JCI table of contents
... of amyloid-associated neuritic dystrophy in PDAPP transgenic
mice. AUTHOR CONTACT: David M. Holtzman Department of Neurology, Washington University, St. Louis, Missouri, USA. Phone: 314-362-9872; Fax: 314-362-2826; E-mail: Holtzman@neuro.wustl.edu . This article is available at http://www.jci.org/cgi/conten...
Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
...sorb more contaminants, researchers found that the transgenic
plants handily beat out their wild-type counterpar...ronmental Science and Technology , show that three transgenic
lines of the Indian mustard plant, Brassica juncea, absorbed two to four times more selenium from co...
Study shows naturally occurring proteins protect against rapid tumor growth
...ic possibilities, the researchers then developed a transgenic
mouse that overproduced the endostatin protein in quantities that mimicked Down syndrome patients (a 1.6-fold increase over normal) who, due to an extra copy of chromosome 21, have elevated levels of the protein. As predicted, tumors in this group of...
Diabetes' link to obesity broken in mice
...earned, they applied a drug treatment in their new transgenic
mice and in a different, previously established mouse line that suffers from obesity and a diabetes-like condition. In both groups, the drug increased insulin sensitivity, which is a primary goal of diabetes treatment. "These results confirm that t...
Signaling protein builds bigger, better bones in mice
...red mice that inherited the new gene to create the transgenic
animals used in their research. Kurt D. Hankenson,...nett and Hankenson discovered that femurs from the transgenic
mice had almost four times as much bone, and were mechanically stronger than femurs from control mic...
Fox Chase Cancer Center scientists identify immune-system mutation
...nician Yi Zhang; Xiang Hua, manager of Fox Chase's transgenic
mouse facility; Fox Chase research associate Emmanuelle Nicolas, Ph.D.; and Weihong Xu, Ph.D., and Bruce A. Roe, Ph.D., both of the University of Oklahoma's department of chemistry and biochemistry....
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