Tag: "transgenic" at biology news

News tips from the Journal of Neuroscience

...r ablation. To track the neurons, the authors used transgenic zebrafish that expressed green fluorescent protein (GFP) in cerebellar precursor neurons of the upper rhombic lip. With in vivo timelapse confocal microscopy, the authors watched these cells migrate toward the MHB, turn ventrally, and settle at the...

Sperm created in the laboratory from embryonic stem cells produce viable progeny

...as for developing new strategies for generation of transgenic mice and may one day facilitate nuclear transfer technology and infertility treatment," offers Dr. Nayernia. ...

Friend or foe: Could a protein linked to Alzheimer's be related to vision loss in seniors?

...of their retinas. "We hope our experiments with transgenic mice will provide some clues as to what apoE is doing in the retina and why one form of apoE versus another would predispose someone to having macular degeneration," Fliesler says. "At this point, it makes no sense to me that the same molecule would ...

The aging-clock connection

... circadian clock and aging. Studying a strain of transgenic mice lacking the core circadian clock gene, Bmal1, Dr. Antoch and colleagues determined that BMAL1 also plays an important role in aging. Bmal1-deficient mice display a marked premature aging phenotype: By 4-7 months of age, the Bmal1 knockout mice e...

Researchers develop novel mouse model to witness immune system attack on chlamydia

... protein. These mice are known as T cell receptor transgenic (TCRtg) mice and have none of the T cell diversity found in a normal mouse. Starnbach and his team harvested T cells from the Chlamydia-specific TCRtg mice, labeled them with a dye, and injected them into normal mice. By boosting the number of Chlamy...

Gene breakthrough heralds better prospect for malaria solution

...ecent years there has been great interest in using transgenic Wolbachia as a way of modifying natural population..." said Dr Heath. "We were then able to work with transgenic flies which express the zipper gene more when warmed up slightly for periods of one hour during thei...

News tips from the Journal of Neuroscience

...pressing T-lymphocytes were upregulated in the PLP transgenic mice, and the T-cells were closely associated with major histocompatibility complex I (MHC-I). The authors surmised that MHC-I+ mutant oligodendrocytes were targeted by T-cells. Flow cytometry experiments confirmed that the brain CD8+ cells were acti...

JCI table of contents: August 1, 2006

...alifornia, San Francisco, designed and developed a transgenic mouse expressing an antiCTLA-4 antibody on B cells that was capable of selectively inhibiting activated T cells and T celldependent B cell responses and prevented autoimmune diabetes in these animals. The study suggests that selective engagement of C...

Transgenic goat's milk offers hope for tackling children's intestinal disease

...alifornia, Davis, have found that milk produced by transgenic goats, which carry the gene for an antibacterial e...h. "This goat's milk represents one of the first transgenic food products that has the potential to really benefit human health," said Professor Jim Murray, who...

Remote control for human growth hormone gene expression

..., and CD79b into a group of mice. As a result, the transgenic mice expressed high levels of human growth hormone...79b played a significant role in hGH expression in transgenic mice, Ho then inserted a special piece of DNA into the locus control region. This DNA insertion spec...

Novel pathway identifies rapamycin as tumor angiogenesis inhibitor

...estigate the function of Akt, the researchers used transgenic mice that expressed activated Akt in normal endothelial cells without the complicating influence of tumor cells. Activation of Akt stimulated formation of abnormal blood vessels in healthy, normal tissues. The Akt-induced vessels had the same struc...

Constant lighting may disrupt development of preemies' biological clocks

...ant light for the same period. They used a special transgenic strain of mouse with an artificial gene that produces a green fluorescent protein under the control of one of the genes associated with the biological clock. As a result, when the neurons are active they produce a bright glow. This allowed the scie...

Mouse mimics chronic leukemia, will aid drug development

...gs for the disease. The mouse, called the TCL-1 transgenic mouse, develops a malignancy that closely mimics chronic lymphocytic leukemia (CLL). The lack of an animal model has greatly hampered the development of new treatments for CLL as well as research into its causes and the changes that drive drug resist...

News tips from the Journal of Neuroscience

...he lush 1 mutation eradicated VA sensitivity in transgenic flies misexpressing Or67d. Thus, VA sensitivity requires both Or67d and LUSH. Visualizing a netrin gradient Timothy E. Kennedy, Hao Wang, Wallace Marshall, and Marc Tessier-Lavigne Chemotropic guidance cues can act through gradients formed ...

Brain enzyme treatment relieves memory lapse in Alzheimer's mice

...ble to restore a great deal of brain activity in a transgenic mouse model of Alzheimer's disease," said Michael ...ain slices treated with A and in slices taken from transgenic mice with mutations that lead to elevated A and associated cognitive decline. The researchers next...

After insects attack, plants bunker sugars for later regrowth

...n the leaves attacked by insects. With the help of transgenic tobacco plants with constantly downregulated GAL83, they measured the same effect as in the nontransgenic, larvae-infested plants: the increased transport of carbon into the roots, and the utilization of this carbon for seed production at the end of ...

Researchers identify neurons that assign value during learning

...o tackle this question, the researchers engineered transgenic fruit flies that express in distinct nerve cells a special ion channel, "channelrhodopsin-2," whose activity is light-sensitive (the protein is normally found in green algae). As a result of expressing channelrhodopsin-2, neurons could be activated s...

Cabernet sauvignon red wine reduces the risk of Alzheimer's disease

...thology, and memory deterioration in ~11-month-old transgenic mice that model AD," reported researchers Dr. Giulio Maria Pasinetti and Dr. Jun Wang at Mount Sinai. "This study supports epidemiological evidence indicating that moderate wine consumption, within the range recommended by the FDA dietary guidelines ...

Most widely used organic pesticide requires help to kill

... (Bt) toxins could be deployed more effectively in transgenic crops by exploiting the role of insect-borne bacteria that enhance insecticidal activity," the Wisconsin team writes in its PNAS report. What's more, the insight that gut microbes mediate the effects of bacterial toxins could have application in hu...

Discovery of the first resistance gene to rice yellow mottle virus

...cing resistance to RYMV. The results show that the transgenic plants have only partial resistance, and for only ...ction, the strategy of introducing a viral gene by transgenic techniques does not bring any advantages compared with the use of natural resistance. This research...

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(Date:10/17/2014)... shown for the first time how bacteria can grow ... them the opportunity to get tremendous insights into bacteria ... also discovered the bacterial growth in chronic lung infections ... down by the immune cells. The researchers discovered the ... the bacteria, forcing the bacteria to switch to a ...
(Date:10/16/2014)... wages war on the human body. Battles are ... In pancreatic cancer, this stalemate—known as tumor dormancy—can ... malignant, a phenomena that is poorly understood. ... laboratory of Salvatore Torquato, a Professor of Chemistry ... surrounding tumor dormancy and the switch to a ...
(Date:10/16/2014)... have a new synthesis of recent research findings to ... in the two states. , The Ecology and ... Washington: A Synthesis of the Relevant Biophysical Science and ... published by the U.S. Forest Service,s Pacific Northwest Research ... managers for a synthesis of the large body of ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2
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