Tag: "translation" at biology news
New grants bolster efforts to generate faster and cheaper tools for DNA sequencing
...am will modify key components of the ribosome the translation
system that cells use to build proteins on messenger RNA templates to read out the sequence of nucleotide building blocks along that message. Any DNA molecule can be converted to such a message, so by sequencing the messenger RNA, the sequence of th...
MicroRNA conflict resolution
...nous let-7 miRNAs and monitored its effects on the translation
of luciferase reporter mRNA. The researchers found that let-7 miRNAs recruited miRNP complexes containing Ago2 and GW182 proteins to target mRNAs, resulting in mRNA deadenylation and translational repression. These findings suggest that miRNAs int...
Penn researchers discover how microRNAs control protein synthesis
...tists know that most miRNAs in mammals repress the translation
of RNA to protein, the molecular steps by which they achieve regulation are largely unknown. By studying the relationship between human miRNAs and the regulatory protein Argonaute2 (Ago2), lead author Marianthi Kiriakidou, MD, Assistant Professor of ...
A small leak will sink a great ship
...esent in messenger RNAs (mRNA) and prevent thereby translation
of the mRNA into a protein: the respective gene falls silent. By this interaction microRNAs can influence whole chains of control events. Mutations in microRNAs are rare, so this is the first example for the functional similarity of a plant microRNA...
Stem cell licensing deal positions Toronto as world leader in technology
...eat example of how a university can facilitate the translation
of professorial research from the university laboratory to commercial reality for the benefit of the public. Currently, TRT technology is available to the Canadian public through CCBB, which markets HUCPVCs as Peristem. Once the baby is born, a hea...
Researchers shed light on mechanism of action used by anti-cancer drug
...ino acids. However, the mechanism by which protein translation
was inhibited by sorafenib remained largely unknow...process that serves as a critical brake on protein translation
in cells subjected to ER stress. Interestingly, they also found that sorafenib, by virtue of its abi...
News tips from the Journal of Neuroscience
.... dissected the signaling pathways that coordinate translation
at the CA3CA1 synapse. Like LTP itself, translation
required the coincident activation of two pathways. The kinase mammalian target of rapamycin (mTOR) ...
Newly identified mechanism for silencing genes points to possible anti-cancer strategies
...fere with gene transcription into messenger RNA or translation
of messenger RNA into protein. In a new study pu...were also acting in some other way to inhibit gene translation
into protein. By tracking the associations between molecules involved in generating microRNAs and ot...
Mechanism of microRNAs deciphered
...tion as locks for messenger RNAs and prevent their translation
into proteins, but how they bring about this effec... miR2, an important microRNA in fruitflies, blocks translation
very early on, even before the cellular machinery needed can assemble. Bound by miR2 a messenger RNA...
UCLA molecular biologists convert protein sequences into classical music
...written by colleague Frank Pettit, that uses their translation
rules to convert the protein sequences to music. They hope this will speed up the translation
of large segments of genomes. Takahashi first converted to music the human ThyA protein, which mak...
Burroughs Wellcome Fund awards $14M to support physician-scientists
...ers and targeted therapies for human lung cancer: translation
from a mouse model Joseph C. Wu, M.D., Ph.D. Stanford University Molecular and cellular mechanisms of cardiac regeneration Mark Nan Wu, M.D., Ph.D. University of Pennsylvania Identification of novel genes that regulate sleep in Drosophila mel...
The sound of proteins
...n by a collaborator Frank Pettit, which uses their translation
rules to convert amino acids into music and hope it will speed up the translation
of large segments of genomes. Further examples of converted proteins and the computer program are ac...
New network launches to keep UK at forefront of stem cell science
...ms to enhance basic research and to help speed its translation
into clinical applications. Malcolm Wicks, Minister for Science, will say at a launch event in London later today: "Stem cell research is an area which offers the potential to provide cures for some of our most debilitating diseases, which affect s...
AACR, FDA and NCI announce cancer biomarkers collaborative at the AACR 2007 annual meeting
...derstanding of cancer in all of its forms, yet the translation
of this knowledge into medical practice remains painstakingly slow," said William N. Hait, M.D., Ph.D., President of the American Association for Cancer Research. "Therefore, we are joining forces with our partners to find new ways of exploring the u...
India's biotech industry emerging as world innovator, collaborator, competitor
...ease training programs in advanced biotech; Ensure translation
of initiatives in the draft Biotech Strategy into policies that increase effective collaborations between public and private institutions and encourage academic scientists to pursue entrepreneurial ventures to commercialize research. Create a favorab...
Mutation improves memory, may lead to memory-enhancing pill
... both its transcription into messenger RNA and the translation
of that messenger RNA into functional proteins. ...ise the interesting possibility that regulators of translation
could serve as therapeutic targets for the improvement of memory, for instance in human disorders as...
To sleep, perchance to dream: New insight into melatonin production
...esis. The researchers found that rodent AANAT mRNA translation
is mediated by IRES (internal ribosome entry site) elements in the 5' end of the transcript, through binding of another protein, called hnRNP Q. In fact, siRNA knock-down of hnRNP Q reduced AANAT and melatonin production under nocturnal conditions....
Brain tissue reveals possible genetic trigger for schizophrenia
...es of the protein coding mRNA, thus preventing the translation
of mRNA to protein. When a cell needs certain proteins, the microRNAs may disconnect, thus allowing protein expression to resume. Using postmortem prefrontal cortical brain tissue of people with schizophrenia and persons who had no psychiatric il...
Largest physics meeting of the year, in Denver
...s original and the parody, and how Barbara Gamow's translation
compares to both. (U20.2) SHORT DESCRIPTIONS OF SOME ADDITIONAL TOPICS OF INTEREST AT THE MEETING making things invisible through cloaking (papers U44.11, W38.1, X38.3) counting clouds (V7.3) diamonoids (U27.14) glial cell pattern formatio...
USP 30-NF 25 in English and Spanish now available
..., 2007. The Spanish version is an exact scientific translation
of the English version; which will enable Spanish-speaking pharmaceutical scientists and professionals to use USP-NF in their own language. This second version furthers US Pharmacopeias endeavors to reach the international pharmaceutical industry. ...
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