Tag: "translation" at biology news
UCI receives major grant to help create national methods and standards for functional brain imaging
...rk hope to speed the rate of discoveries and their translation
to treatments for diseases such as schizophrenia, Parkinson's disease, depression and dementia. Based on success in the neuroscience studies, the overall BIRN project will expand to create a sustainable, scalable, widely available electronic infrastr...
News tips from the Journal of Neuroscience
...t corepressor proteins. In a second approach, REST translation
was blocked by a morpholino antisense oligonucleotide (MoXREST). Activation of dnXREST resulted in decreased expression of several neuronal genes at the late blastula stage. But perhaps more importantly, XREST was required for neuroectodermal pattern...
Mispairs in genetic material make protein synthesis more efficient
...through the ribosome, the cellular organelle where translation
occurs. In fact, removing the mispair or repairing it to make it a correct matched pair inactivated the molecule completely. "The wobble pairs fit together at an angle and the bonds are much less stable than matched pairs," McClain explains. "This...
Bridging the gap between basic science and medical practice
... the Howard Hughes Medical Institute to foster the translation
of basic science discoveries into new medical treatments. The goal of the $10 million national initiative is to train scientists with a better understanding of medicine so they are better equipped to conduct research that benefits the diagnosis and t...
Second low-oxygen pathway hints at cancer, cardiovascular disease physiology
...t that the HIF pathway leads to the activation and translation
of nearly 200 target genes essential to the cell's protective physiological changes, while the second and most recently discovered pathwaythe mTOR pathwayinhibits protein synthesis. "The cell needs to take what energy it has to redirect to the molecu...
Protein translation in sperm
...niversity, Israel) now show that, in fact, protein translation
does take place in mammalian sperm prior to fertil...pacitation phase. They identify that mitochondrial translation
machinery (as opposed to cytoplasmic) directs translation
of nuclear-encoded genes in sperm, and tha...
New images capture virus in extraordinary detail
...t DNA is the genetic material and determining that translation
of genetic material into proteins is based on a triplet code. Luria's legacy at MIT's biology department is carried on today, said King. Shortly after World War II, the Institute got one of the first electron microscopes in the United States, and Lur...
Language barrier just one roadblock to diabetes control for Chinese-speaking immigrants
...als, the Chinese-speaking group reported requiring translation
35 percent of the time. The 11 patients that required translation
scored lower than the others on the diabetes knowledge test. The investigators then provided both g...
A real time look at interactions between RNA and proteins
... those involved in the targeting, degradation, and translation
of RNAs into proteins. Once identified, the Eberwine team uses another technology they developed to find the other RNA cargos that bind to that RNA-binding protein. These are other RNAs that likely co-regulate RNAs associated with disease. The rese...
Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
...nces at the Mellon College of Science. "Successful translation
of this work to the clinic ultimately will reduce the number of biopsy procedures and should greatly improve the quality of life for cardiac transplant patients, especially children," added Ho, who directs the Pittsburgh NMR Center for Biomedical Res...
Protein 'nanosprings' most resilient found in nature
... by the ankyrin springs could allow for very rapid translation
of mechanical forces into biochemical signals, he said. The proteins' spring-like properties could also be important for furthering the development of nanotechnology, Marszalek added. "These nanosprings could provide a wonderful material anytime you ...
Translational control by RINGO/Spy
...tes. Further analysis revealed that RINGO/Spy mRNA translation
is under the control of the Pumilio protein, Pum2. "Because CPEB-mediated translation
is important not only for germ cell development but also for early embryonic cell division and neuro...
Long-term memory controlled by molecular pathway at synapses
...copy that conveys information from DNA to a cell's translation
machinery -- is transported to synapses as a memory begins to form. This mRNA transport, and the protein synthesis that follows, are facilitated by components of the RISC pathway, which use very short RNA molecules called microRNAs to guide their act...
Leibniz Prize winners 2006
...o solve the entire puzzle of how transcription and translation
are regulated. Patrick Cramer studied chemistry in Stuttgart, Heidelberg and Bristol, and obtained his doctorate at the European Molecular Biology Laboratory in Grenoble, France, before spending two years as a postdoctoral researcher at Stanford Uni...
New insights into protein synthesis and Hepatitis C infections
...3-D model of the protein complex called eukaryotic translation
initiation factor 3 (eIF3). The model showed that...omplex. The eIF3 complex also interacts with other translation
elements that bind at the start of the mRNA, prevents premature joining of the 40S and 60S ribosomal...
Researchers discover new form of cancer gene regulation
..., it binds to the Quaking protein and inhibits the translation
event. This means that all of the controls that the cell has on the gene for GLI1 can be present and active and the GLI1 is still not produced. Significantly, the study demonstrated that this regulation is conserved from human to the worm, Caenorhab...
New and sharper X-rays of cell's ribosome could lead to better antibiotics
...blocks - to the lengthening protein chain. As this translation
takes place, transfer RNA (tRNA) constantly brings in amino acid building blocks, while energy-supplying molecules in the form of GTP (guanosine triphosphate) cycle through. They found that after the bond - called a peptide bond - forms between the g...
JCI table of contents November, 2005
...n nNOS mRNA containing a region that permits rapid translation
of the full-length protein. Thus, alternate promoters can serve not only to direct transcriptional activation in a developmental stage- and tissue- specific manner but can also confer the ability to rapidly alter cell phenotype in response to a spec...
Agns Vignery, osteoporosis researcher, named Yale-Pfizer Visiting Faculty
...s being refined in rodents, anticipating its rapid translation
to humans. "One vision for the program is to enhance the scientific understanding between Pfizer and Yale, and, more broadly, between industry and academia. We have already seen how beneficial these interactions can be," said Karen Houseknecht, presi...
Study provides insight into cellular defenses against genetic mutation
...rrors are detected. A second "steady-state" round translation
then directs the mass production of normal protein... cap-binding complex is part of the larger pioneer translation
initiation complex, which enables mRNAs to be read by ribosomes during quality control review. Previ...
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