Babies born after surgery on eggs
...n have been born after doctors performed a kind of transplant surgery on the eggs of their mothers, for whom normal IVF had failed. But other experts are concerned about the long-term safety of the technique. The technique, developed by Chii-Ruey Tzeng's team at Taipei Medical University in Taiwan, involves add...NIH funds new bioinformatics resources at UT Southwestern
...iseases, including allergy, autoimmunity and organ transplant rejection. The goal is to integrate data from different kinds of biomedical research, such as clinical trials, animal modeling and studies using cultured cells, allowing researchers to better identify altered genes and proteins that lead to disease. ...Researchers grow sperm stem cells in laboratory cultures
...94, this same research team developed the means to transplant spermatogonial stem cells from one mouse into another. The recipient mice then produced sperm--fully capable of fertilizing egg cells--with the genetic characteristics of the donor mice. Because they can now grow spermatogonial stem cells in cul...Tiny exosomes extracted from donor cells may be 'magic bullet' for drug-free transplants
...d by dendritic cells may hold the key to achieving transplant tolerance the long-term acceptance of transplante...search will determine if we can actually influence transplant tolerance," explained Dr. Morelli, assistant professor of surgery at the University of Pittsburgh Sc...New program examines stem cells' potential to repair, replace damaged tissue
...is potential here - when a patient needs a kidney transplant or when you have a patient with burns who needs skin grafts - the possibilities are endless," he says. Dr. Karl H. Wenger, a biomedical engineering scientist who is director of research for the MCG Department of Orthopaedic Surgery, will develop a bi...Sex-determining genes of infectious fungus resemble human Y chromosome
...ho lack a functioning immune system, such as organ transplant recipients and those with HIV/AIDS, Heitman added. A single fungal mating type spurs the vast majority of all C. neoformans infections, he explained, suggesting that sex determination and virulence are closely linked. Collaborators on the...U. Va. Health System to develop new approaches to treat type 1 diabetics with islet cell transplants
...er this year, U.Va. performed the first islet cell transplant in Virginia. The grant could increase the number o...ills insulin-producing cells in the pancreas, this transplant can offer hope of a life without daily insulin injections. The procedure involves injecting millions...Study shows stem cells can preserve vision
...e cells that were on the verge of dying before the transplant appeared to regain or retain their function. The researchers speculated that the transplanted cells were secreting a factor or substance that saved these fragile cells. (There is growing evidence that rod cells keep cone cells alive by secreting a sp...Antipsychotic drugs stop fatal viral infection in brain cells
...s with suppressed immune systems, including kidney transplant recipients, cancer patients undergoing chemotherapy and an estimated 4 percent of people with AIDS. PML is caused by the JC virus, which destroys the cells that produce the fatty sheath that covers nerve cells. This causes dementia, vision loss, move...Scientists generate human islet precursor cells in culture
... optimal for use in humans, so we are not ready to transplant these cells into people. Still, I am encouraged." The researchers removed islets from human cadaver pancreata, as is done before islet transplantation, and exposed these islets to a medium containing fetal bovine serum. Over 17 days the cells in th...Finding could improve safety of stem cell transplants
...embryonic layers," says Dr. Bieberich. "But if you transplant them, you are at risk of forming teratomas." However, at least in the culture dish, when they added PAR-4's lethal dance partner, ceramide, to the mix, PAR-4- and Oct-4-expressing cells again died before they could do harm. The...Stronger therapy better for AML with normal genetics
...ose cytarabine and etoposide followed by stem-cell transplant were more effective than was one cycle of high-dose cytarabine alone. "There are many different approaches to post-remission therapy, and they include using fewer cycles of high-dose cytarabine or reducing the dose of the drug, but our st...Racial disparities noted in immune system genes
...the inflammatory response include premature labor, transplant rejection and autoimmune disorders such as multiple sclerosis and scleroderma again, all more common among African Americans. Specifically, scientists compared genetic data on 179 African-American and 396 white women who sought prenatal care and del...Efforts to clone primates move forward
...ate stem cells by nuclear transfer may soon permit transplant investigations to learn whether stem cells created in this way are truly immune-matched. In addition to replicating the South Korean method of gently squeezing out the egg's nucleus rather than the traditional practice of removing genetic material wi...JCI table of contents, December 15 2004
... metastases to lung and bone in experimental tumor transplant models. This effect has long been attributed to platelet-mediated enhancement of tumor cell survival and tumor cell escape from the blood into the surrounding tissue, as well as the development of new blood vessels to support tumor growth. In the Dec...Current human embryonic stem cell lines contaminated UCSD/Salk team finds
...ally, only ever exposed to serum from the intended transplant recipient." "However, such an approach could not be pursued under existing rules for the use of federal grant dollars," Varki said. The first author of the Nature Medicine study is Maria J. Martin, Ph.D., a post doctoral researcher in Varki's lab at ...Gene therapy promising for growing tooth-supporting bone
...py outside the body using a tissue biopsy and then transplant the genetically-modified cells back into the patient, but this would require two surgical procedures instead of one. The Molecular Therapy paper is titled "BMP Gene Delivery for Alveolar Bone Engineering at Dental Implant Defects," and the work was s...Circles of DNA might help predict success of stem cell transplantation
...physicians predict whether a bone marrow stem cell transplant will successfully restore a population of infectio...ysicians predict whether children receiving such a transplant will experience either failure or significant delay in the reconstitution of the T cell population. ...New stem cell source could boost bone marrow success
...ased cells with fresh ones found inside bones. The transplant requires hematopoietic stem cells (blood-forming s...with added mesenchymal stem cells can increase the transplant success rate. "Mesenchymal stem cells can leave the marrow during injury and actually home to the ...Embryonic stem cells treated with growth factor reverse hemophilia in mice
...ofessor of surgery and division chief of abdominal transplant surgery. Moreover, he said, the PEP cells robustly engraft within the liver and were not recognized by the immune system as foreign. "Within a few weeks, PEPs became hepatocytes," Fair added. "They went from something that is a very early grandpare...