Tag: "transplant" at biology news
Replacing insulin is top-ranked breakthrough foreseen for health in developing world
...uma and other causes. It moves beyond traditional transplant
and replacement therapies to include the use of stem cells, soluble molecules, genetic engineering, tissue engineering, and advanced cell therapy. There is increasing research in regenerative medicine in both developed and developing countries. Alre...
Transplant cures rats' type 2 diabetes without need for immune suppression drugs
...rch instructor in medicine, showed that they could transplant
the cells in a way that lets them grow into insuli...performed to treat type 2 diabetes. "Furthermore, transplant
recipients require antirejection drugs, so they are trading one disease, diabetes, for another, immu...
What animals can tell us about hemorrhage, organ transplants and aging
...one day extend the time we can preserve organs for transplant
and give doctors time to find a suitable recipient, Carey and Andrews said. The research could also profoundly change how we treat people who are severely hypothermic or have suffered massive blood loss. No fountain of youth -- yet Human life e...
JCI table of contents: Oct. 2, 2006
...s been developed successfully for the treatment of transplant
rejection. One of the side effects of OKT3 is diarrhea, which is thought to be caused by the soluble factors released by the immune cells (T cells) activated by OKT3. Exactly how these soluble factors cause diarrhea has not been clearly established. ...
Study could help transplant surgeons predict rejection/tailor medications
... 2006 A Children's Hospital of Pittsburgh of UPMC transplant
surgeon and researcher has received a grant from t...lth to study genetic factors that could predispose transplant
recipients to rejection. The goal of the four-year, $1.1 million grant is to study these factors in...
Scientists find a key to immune system's ability to remember
... AIDS, and help victims of autoimmune diseases and transplant
patients whose immune systems reject donor organs....essing T cell response after transplantation. Now, transplant
patients require life-long regimens of drugs to suppress immune response to the foreign cells in the...
U-M study offers new perspective on nitric oxide signaling in rheumatoid arthritis
.... For example, without closely matched antigens, a transplant
patient's immune system will reject a donated organ. "Although the hypothesis that RA is an autoimmune disorder is widely accepted, there is no convincing evidence that it is correct," says Joseph Holoshitz, M.D., associate professor of internal med...
Computing catches up with theory
... a major cause of strokes, heart attacks and organ transplant
rejection. In 1970, Richardson, who had been working on the clotting problems associated with ar-tificial organs, saw a paper describing the time course of clot formation in uninjured blood vessels. Gustav Born and his co-author, Nicola Begent, had...
Newly discovered proteins associated with cystic fibrosis
...hom had end stage disease and were scheduled for a transplant
-- to healthy tissue. The healthy tissue was obtained from 10 patients undergoing surgical removal of a lung tumor. The researchers used the healthy portion of lung tissue which is usually excised along with the tumor. The study looked at tissue sam...
Proteins may predict lung transplant rejection
...to 20 months before the rejection occurred. Lung transplant
patients have the highest mortality rate of organ ...udy used 411 lavage samples obtained from 137 lung transplant
recipients from 1993-1996, Wendt explained. A lavage is a liquid that doctors introduce into the lun...
When Gleevec is not enough
... blast crisis currently necessitates a bone marrow transplant
for survival. "Sometimes the BCR-ABL protein itself has a mutation, which makes it less susceptible to imatinib," said Li. "But in some patients who do not respond to imatinib, there's no imatinib-resistant mutations detected and the disease still ...
An AIDS-related virus tricks cells to become tumors, new Penn study finds
... and those who are immune suppressed such as organ transplant
patients are at high risk for developing Kaposi's sarcoma and another cancer called primary effusion lymphoma. The study describes how a KSHV-encoded protein, called latency-associated nuclear antigen, or LANA, tricks the cell into destroying two ...
Non-steroidal anti-inflammatory drug increases liver damage in mice carrying mutant human gene
...e liver problems while others will require a liver transplant
before they are two years old. Only 10 to 20 percent of infants with alpha-1-ATZ genes will develop clinically overt liver damage. "We don't yet know the mechanism accounting for such wide variability in this disorder, but other genetic and environ...
Long-term cancer risk follows stem cell transplant recipients
Hematopoietic stem cell transplant
(HSCT) recipients face a significant long-term ris...er, particularly if they were older at the time of transplant
or received stem cells from a female donor, according to a new study. Published in the January 1, 20...
A new approach to growing heart muscle
...s. Already, the U-M team has begun experiments to transplant
BEHM into the hearts of rats that have suffered heart attacks, and see if the new tissue can heal the damage. This work is being conducted by Francesco Migneco, M.D., a research fellow with the Artificial Heart Laboratory. Further studies will implem...
Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
...an identical twin, patients undergoing bone-marrow transplant
(also known as hematopoietic stem cell transplant,...ailure and death. It strikes some 30-60 percent of transplant
patients, depending on how closely matched the donor is, and is kept in check only by eliminating ot...
A transplant in time
...he National Academy of Sciences (PNAS), how such a transplant
might, in the future, be made feasible. Previous attempts to treat genetic disease by transplanting (mother to daughter) a spleen, an organ that can manufacture a number of the missing proteins in some such diseases, had made little headway due t...
Researchers first to map gene that regulates adult stem cell growth
...ble in umbilical cord blood, which also is used to transplant
healthy stem cells in blood marrow transplants. Currently, stem cell transplants with cord blood can only be used in children because cord blood does not contain enough stem cells for an amount needed to be transplanted into an adult. The only stem ...
U of MN adult stem cell research shows promise for transplant therapies
...sing the supply of cells available for bone marrow transplant
patients.The researchers used multipotent adult progenitor cells (MAPCs), which can be isolated from bone marrow and have the ability in the laboratory to differentiate into different specific types of cells such as liver, bone and neural cells. Cat...
NIH gives PITT $13 million grant for chronic obstructive pulmonary disease research
...ty of life. Tissue changes characterizing COPD and transplant
rejection are similar in many ways, and inhaled cy...e is effective in treating organ rejection in lung transplant
patients. Studies will include a 28-day clinical safety trial involving particular attention to airw...
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