Tag: "transplantation" at biology news
New clues for treatment of liver cancer
...transplanting the cells into adult mice. Following transplantation
(by injection into the spleen), the cells can become part of the recipient mouse's liver. Depending on the initial, genetically engineered makeup of the liver stem cells, and on genetic alterations that occur spontaneously after they are transplant...
Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's
...tem cells in patients would alleviate the need for transplantation
of engineered cells, and as a drug therapy, it would be also easy to administer to patients. Moreover, given that similar drugs exist, medicinal chemistry to maximize this effect could be achieved quickly," says Diane Murphy, Ph.D., the NINDS progra...
Researchers aim to cut future need for liver transplants
...r failure ultimately resulting in death, and liver transplantation
is presently the only treatment for acute and chronic liver failure. However, the supply of donor livers is insufficient to meet demand, and in the United Kingdom, 20% of patients waiting for a liver transplant will die from liver failure before a su...
Study establishes safety of spinal cord stem cell transplantation
...es surrounding the spinal cord indicating that the transplantation
had not caused any damage to the animals. "Our ...in animals that are only slightly injured that the transplantation
does not cause visible harm and the injury is not hiding any damage the cells may have caused to the...
Neural stem cells derived from human embryonic stem cells carry abnormal gene expression
...he means, theoretically, that a patient undergoing transplantation
with these neural stem cells would not later devel... "Any stem cells that might one day be used for transplantation
have to be as close as possible to normal stem cells," Fan said. "The next step is to see if we can ...
With few factors, adult cells take on character of embryonic stem cells
... well as the problem of tissue rejection following transplantation
into patients." Those problems could be circumve...mbryonic stem cells. They further reported that transplantation
of the iPS cells under the skin of mice resulted in tumors containing a variety of tissues represent...
Contagious cancer in dogs confirmed; origins traced to wolves centuries ago
...e cancer could be transmitted only by experimental transplantation
of living tumor cells, not by killed cells or cell filtrates. Scientists had also noticed similar chromosomal abnormalities in tumor samples collected in different geographic regions. However, several reports of virus-like particles in CTVT had led s...
Will stem cell-based treatments make a difference to the developing world?
... medicine therapies, such as bone marrow stem cell transplantation
or microencapsulated islet cells using new biomaterials, could provide a permanent solution to treating diabetes and reduce the financial burden caused by the purchase of insulin. The second-ranked application was regenerating failed heart muscle u...
Transplant cures rats' type 2 diabetes without need for immune suppression drugs
...ery of the pig cells is established normally after transplantation
of primordia, and they work just like a normal pan...ing cells has also led to decades of research into transplantation
of human pancreas and islets, the cells that produce insulin. Unfortunately, donor organs are so sca...
JCI table of contents: Oct. 2, 2006
... all the different cell types in the blood and HSC transplantation
is used to treat a number of blood disorders, incl...e human HSCs that are proliferating at the time of transplantation
are not efficiently incorporated into the bone marrow of recipients. So, the authors suggest that tr...
Institute of Medicine elects 65 new members, 5 foreign associates
...A, M.D., president, and professor of pediatric and transplantation
surgery, University of Texas Health Science Center, San Antonio ELLEN WRIGHT CLAYTON, M.D., J.D., Rosalind E. Franklin Professor of Genetics and Health Policy, professor of pediatrics, professor of law, and co-director, Center for Biomedical Ethics...
Study could help transplant surgeons predict rejection/tailor medications
...s have improved survival rates for pediatric organ transplantation
dramatically over the last 25 years. As a result, ...medications are important because, while they make transplantation
possible, they also can have adverse side effects that can themselves become life-threatening, such ...
American research finds twins more likely to have premature menopause
...rst, it was prompted by the recent case of ovarian transplantation
between 24-year-old identical twins at the Inferti...e 14, but this was reversed through ovarian tissue transplantation
from her sister, and she later conceived. Subsequently, several more identical twin pairs came forwa...
Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration
...er to tag rod precursor cells and prepare them for transplantation
The team of scientists found that transplanted p...d cell culture systems will still be needed before transplantation
can be considered ready for testing in humans. Restoring visual function in animals is an import...
JCI table of contents: November 16, 2006
...dy has clinical relevance because it suggests that transplantation
of autologous bone marrowderived progenitor cells might be a viable therapy for the treatment of human diseases that resemble this mouse model of retinopathy, such as ROP. TITLE: Myeloid progenitors differentiate into microglia and promote vascular...
Repair not destruction: A new approach to treating retinopathy
...dy has clinical relevance because it suggests that transplantation
of autologous bone marrowderived progenitor cells might be a viable therapy for the treatment of human diseases that resemble this mouse model of retinopathy, such as ROP....
Long-term cancer risk follows stem cell transplant recipients
...isk of developing a solid neoplasm post-allogeneic transplantation
continues to increase with time," suggest the authors, "extended follow-up will be needed to more fully assess the incidence and risk factors for their development."...
Stem cells found in adult hair follicles may provide alternative to embryonic stem cells
...ted into the spinal cord, remaining at the site of transplantation
and not forming tumors," Dr. Sieber-Blum says. According to Dr. Sieber-Blum, subsets of the epidermal neural crest stem cells express markers for oligodendrocytes, the nerve-supporting cells that are essential for proper neuron function. She has bee...
Researchers create genetically matched embryonic stem cells for transplantation
... immune system, making them potentially useful for transplantation
therapies. There are several caveats, including the fact that only females could benefit from this technique, donating their own eggs to generate the stem cells, and concerns that the tissues derived from this special type of embryonic stem cells mig...
A transplant in time
...us, the scientists fixed the ideal time for spleen transplantation
at 42 days. Hemophiliac mice with spleen tissue transplanted from pig embryos at this time experienced completely normal blood clotting within a month or two of implantation. Although a number of problems would need to be surmounted before resear...
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