Dramatic results from combo therapy surprises Krabb-disease researchers
...ed as well as it did. A combination of bone marrow transplantation and gene therapy greatly lengthened the lives of l...hat under extreme treatment conditions bone marrow transplantation could extend the lives of these mice to an average of about 80 days (untreated Twitcher mice live to...New culture method for hepatitis C virus uses primary hepatocytes and patient serum
...arcinoma, represents the foremost reason for liver transplantation in much of the U.S. Study of HCV replication within liver cells, or hepatocytes, has been hampered by a lack of adequate virus culture systems. Some systems allow the virus to infect cells but do not permit prolonged replication and production of ...Prediction of graft-versus-host disease by gene-expression profiling of donors and more
...chers studied 246 recipients of hematopoietic cell transplantation and their donors. They showed the value of more accurate matching that could be achieved by this technique, in that mismatching was associated with a significantly increased risk of severe acute graft-versus-host disease. Citation: Petersdorf EW, Ma...JCI table of contents: Feb. 1, 2007
...eactive T cells boosted by hematopoietic stem cell transplantation Although treatment regimens involving the infusi...ve strategies) and a hematopoietic stem cell (HSC) transplantation enabled infused tumor-reactive CD8+ T cells to increase in number more than pre-treatment with nonmy......, has implications in reproduction, clinical organ transplantation and immune regulation. In addition to sequencing the horse genome, researchers produced a map of horse genetic variation using DNA samples from a variety of modern and ancestral breeds, including the Akel Teke, Andalusian, Arabian, Icelandic, Qua...New hope for regenerative medicine
... source of embryonic stem cell derived tissues for transplantation into the female from which they were derived. This study shows for the first time that parthenogenetic blood cells can replace those of an immunocompromised adult mouse. McLaughlin and colleagues also show that this is also possible using embryoni...UT-Houston scientists develop new procedure to differentiate human embryonic stem cells
...editary lung disorders most likely to benefit from transplantation of alveolar epithelial type II cells include respiratory distress syndrome of the newborn, alpha-1 related emphysema and cystic fibrosis, Wetsel believes. All three of these diseases are caused by single gene defects and therefore have been logical c...Burroughs Wellcome fund awards $8.25 million in grants to physician-scientists
...tion and GVL in allogeneic hematopoietic stem cell transplantation Pradeep Singh, M.D. University of Washington Gallium as an antimicrobial and anti-biofilm agent: a trojan horse strategy that disrupts bacterial iron metabolism Russell Van Gelder, M.D., Ph.D. Washington University Pathogenesis of inflammato...JCI table of contents: March 15, 2007
...ls able to respond to the immunizing protein. Upon transplantation into mice lacking their own T and B cells, the T and B cells in the aLNs responded to further immunization with the specific protein, known as a secondary immune response. Importantly, the cells in the aLNs making this secondary immune response were ...Gene hunters, patent prospectors leave indigenous communities in Pacific feeling besieged, betrayed
...lands nearly became the site for the world's first transplantation of pig cells into living humans (xenotransplantati...w technologies, says Reid. The proposed pig cell transplantation episode illustrates that "some companies are willing to take advantage of this lack of capacity and ...International Society for Heart and Lung Transplantation 27th Annual Meeting and Scientific Sessions
...an allocation Medical device alternatives to heart transplantation facing a shortage of organ donors The application of nanotechnology in transplantation New discoveries in pulmonary hypertension Immunosuppression finding the right drug cocktail after ...Gene test shown to measure heart function after transplant
...n the lab of Mario Deng, M.D., director of cardiac transplantation research and associate professor of clinical medicine at Columbia University College of Physicians and Surgeons, and cardiologist at NewYork-Presbyterian Hospital/Columbia University Medical Center. The presentation is based on preliminary data on 80...Harvard and U. Pittsburgh researchers explain carbon monoxide's anti-inflammatory effects
...e it in a controlled fashion, we can not only make transplantation safer, but extend its benefits to many more who need it."...Donald Metcalf receives American Association for Cancer Research Lifetime Achievement Award
... dramatic advance has largely replaced bone marrow transplantation in cancer treatment and has had a major impact on the manner in which chemotherapy is used in cancer patients. As a world-renowned scientist and leader in the cancer research community, Dr. Metcalf is an outstanding choice for the AACR Award for L...The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better
...d after exposing the cells to stress or after cell transplantation in the animals that have muscular dystrophy. Transplantation of female cells leads to a much more significant level of skeletal muscle regeneration," she said. "The male cells exhibited increased differentiation after exposure to oxidative stress, wh...Scientists identify key to integrating transplanted nerve cells into injured tissue
... "We believe that it will ultimately make retinal transplantation and restoration of vision a possibility." He adds that transplantation of donor photoreceptors (in whole retina transplants) may prove to be more beneficial than transplan...Stem cells may look malignant, not act it
...hers evaluated two women who underwent bone marrow transplantation and subsequently developed colonic adenomas, four women who developed skin cancer and one who developed lung cancer. "We questioned where the cancer was coming from was it really from the patient or could it have been from the donor bone marrow t...Existence of muscle-building stem cells points to regenerative therapies for muscular disease
...to new muscle-regenerating therapiesincluding cell transplantation regimens and stem cell-replenishing drugsfor peopl...down the road toward becoming muscle. In contrast, transplantation of Myf-5 negative cells "extensively contributed to the satellite cell reservoir throughout the inje...Enzyme delivered in smaller package protects cells from radiation damage
...pe out their bone marrow cells prior to subsequent transplantation of hematopoietic stem cells, bone marrow stem cells or peripheral blood progenitor stem cells. However, there is increasing concern that such high doses of radiation may have long-term negative effects on healthy tissues and organs, such as the kidne...New treatment increases life time expectancy of patients suffering from advanced liver cancer
...ase have benefited from procedures like resection, transplantation or ablation. Unfortunately, more than 60% of cases of liver cancer are detected in an advanced phase, making chemoembolisation the only available treatment. Chemoembolisation could only be applied to 15% of patients, and there was no other effective ...