Technique for genetically modifying blood stem cells brings cure for blood diseases closer
... In the experiment, mice that received transplants of stem cells modified with mLar-beta-delta-gamma-V-5 had total HbF levels of 17 to 33 percent, which led to significant improvement in their disease. This contrasted with the results in the study using the previously constructed vector, d432 beta-de...UCSD medical researchers use brain cell transplants to correct muscle spasms after aneurysm surgery
...nd that rats receiving the brain, or neuronal cell transplants displayed a progressive recovery of motor function... contrast, the "control" rats that did not receive transplants exhibited no improvement in motor function or spasticity. A post-mortem study of the animals showed...Fat buildup found in hearts of obese or diabetic heart failure patients
...xamined 27 failing hearts that were removed during transplants and compared them to eight donor hearts that were not failing but were otherwise unsuitable for transplant. Eight of the failing hearts (30 percent) showed high levels of triglycerides a fat storage and transport molecule. Levels of triglycerides ...Tiny exosomes extracted from donor cells may be 'magic bullet' for drug-free transplants
...ion with studies involving mice that receive heart transplants following infusion with exosomes from the same donor. A recent French study in rats, while offering no clues as to why, suggests the approach will be successful. In addition, animal studies conducted at Pitt by Paul Robbins, Ph.D., professor of molec...U. Va. Health System to develop new approaches to treat type 1 diabetics with islet cell transplants
... The grant could increase the number of islet cell transplants performed at U.Va. in clinical trials in the coming years. "The idea is to develop a safer, more effective protocol to perfect islet cell transplantation and move the procedure to the next level. There is a lot to do to make this procedure more ...Study shows stem cells can preserve vision
...then placed them and the control mice (without the transplants or with non-stem cell transplants) in dark cages and flashed a series of increasingly lower level lights at both groups over a period of time. Mice are photophobic and stop their normal activity when they detect light. The researchers took advantage ...Menssana research at NJIT receives kudos for FDA-approved breath test
.... The test determines whether patients with heart transplants are showing signs of rejecting the new heart. The FDA said the test might be used as an adjunct to biopsy. The Heartsbreath test costs $500, compared to thousands for a biopsy. More importantly, it is non-invasive and has no risks. Phillips has als...JCI table of contents, 3 January 2005
...number of DA neurons that survive after fetal cell transplants (approximately 10%). While this may be a difference observed between transplantation in monkeys and humans, Langston stresses that it may be necessary for far more DA neurons to survive and for that survival to be long lasting in order to render this...Transplantation of monkey embryonic stem cells reverses Parkinson disease in primates
...number of DA neurons that survive after fetal cell transplants (approximately 10%). While this may be a difference observed between transplantation in monkeys and humans, Langston stresses that it may be necessary for far more DA neurons to survive and for that survival to be long lasting in order to render this...Circles of DNA might help predict success of stem cell transplantation
...Physicians sometimes treat patients with stem cell transplants as part of therapy for a variety of diseases such ...e them with healthy stem cells from donors. If the transplants succeed, the donated stem cells repopulate the blood with healthy red and white cells. The St. Jude...New stem cell source could boost bone marrow success
...umbilical cord, providing new hope for bone marrow transplants and tissue repair. The study, published in the F... up to 1000 therapeutic cell doses." Bone marrow transplants treat diseases such as cancers and immune deficiency disorders by replacing diseased cells with fres...Gene therapy converts dead bone graft to new, living tissue
...one. This has proven successful for the small bone transplants used in spinal fusion, but not for larger grafts, because the proteins' effectiveness wear off in just hours. By contrast, the gene therapy method triggers the tissue surrounding the graft to produce the proteins continuously for up to three weeks, l...Rapid, new test develped for inherited immune deficiency
...recognized. Recent research shows that bone marrow transplants in the first three months of life work better than transplants at a later age. So it is critical to identify affected children immediately after birth. Since the...NHGRI targets 12 more organisms for genome sequencing
... studies; the LEW strain, often used in studies of transplants and immune response; the BB strain, used in studies of diabetes; the FHH strain, also used for cardiovascular studies; the DA strain, used for studies of arthritis and cancer; and the SHR strain, used in studies of hypertension. "The overriding goal ...Infants needing a heart transplant can accept organs from different blood types
...hat infants under one year of age can accept heart transplants from donors of different blood groups without the risk of organ rejection means a better chance of survival for infant patients and more efficient use of donor organs overall. Results will be presented at the International Society for Heart and Lung...Researchers pioneer new gene therapy technique using natural repair process
...tened by systemic infection, and while bone marrow transplants can be used to treat the disease, they are not always successful. "SCID is ideal for this sort of therapy because you only need to correct the defect in a small number of immune cells to fix the problem," said Dr. Porteus, assistant professor of pedi...Molecular testing impact: Heart transplant patients benefit from new technology, easier monitoring
...mage to the heart has occurred. With 4,500 cardiac transplants performed worldwide each year, it is believed that the new molecular testing procedures will alleviate the need for tens of thousands of biopsies and the patient discomfort that accompanies the biopsy. The clinical value of AlloMap testing was demons...Report proposes structure for national network of cord blood stem cell banks
...utinely review the results of cord blood stem cell transplants and guide DHHS and the cord blood banking program ...atching; and make sure that data on the results of transplants are available for decision-making and quality assurance. Although the new center would coordinate t...Stem cells from brain transformed to produce insulin at Stanford
...ons. In rare cases, some patients can receive cell transplants from cadavers, but that source of cells is far smaller than the total number of people who could benefit.......lop the strategies and methods that will make cell transplants possible. "The Regenerative Medicine Program seeks to harness the remarkable advances in stem cell biology and translate them into powerful new therapies," says Kamp. "The program will bring together the interdisciplinary expertise and infrastructu...