University of Leeds strengthens China links in membrane and neurobiology
...so being carried out on the structures of membrane transporters and receptors, which potentially represent targets for novel antibacterial, antiparasite and antidiabetic drugs. Complementing such studies, another major theme of the initiative concerns the flow of membranes between different cellular compartments ...News tips from the Journal of Neuroscience
...ywhere. One question is whether block of monoamine transporters with this drug leads to lasting alterations in the brain. This week, Gray et al. dosed male rats twice weekly between postnatal day 7 (PND7) and PND35 and then tracked immunocytochemical markers out to PND135. In adult rats, the 4 weeks of postnatal ...American Chemical Society's Weekly PressPac -- June 27/July 3, 2007
... width of a human hair. The SWNTs act as efficient transporters for the platinum warhead, carrying it to the tumor cell and then releasing the platinum as an active drug. In one experiment with cultured cells, the SWNTs produced platinum levels inside the cells 6-8 times higher than those for the platinum unit ad...JCI table of contents: June 21, 2007
...thomology All eyes are on the role of glutamate transporters in glaucoma Glaucoma, a leading cause of irreve...ma. They show that mice deficient in the glutamate transporters GLAST or EAAC1 have spontaneous optical nerve degeneration without elevated IOP. In GLAST-deficient ...News tips from the Journal of Neuroscience
... visualize the expression pattern of two glutamate transporters in mice, glutamateaspartate transporter (GLAST) and glutamate transporter-1 (GLT-1). These two transporters are primarily expressed in astroglia and do the heavy lifting in terms of glutamate uptake in the em...Technology reveals 'lock and key' proteins behind diseases
...ith key proteins called ATP-binding cassette (ABC) transporters proteins that, when impaired, can cause disease. One of the best known ABC transporters is the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), which, when disabled by mutation,...Joslin researchers discover a surprising culprit in the search for causes of diabetic birth defects
...s glucose levels are elevated, while other glucose transporters would be saturated at normal glucose concentration...new that the embryo expresses a variety of glucose transporters that bring necessary glucose into the developing cells," said Dr. Loeken, "but what caught my eye wa...JCI table of contents -- February 22, 2006
...st that mice, but not humans, have thyroid hormone transporters able to compensate for the lack of MCT8. Identifying these transporters is important for the development of a good mouse model of the psychomotor retardation caused by MCT8...New mechanism for nutrient uptake discovered
...e. The conservation of this feature in the related transporters in bacteria, fungi, plants, and animals suggests t...nce of this structure in all of the known ammonium transporters suggests that the regulation is still necessary today for all of these organismscyanobacteria in the...Two studies: Speeding development of novel tracer for prostate cancer
...in the body. PET showed the activity of amino acid transporters that "mediate" FACBC, the radiotracer that was dev... FACBC PET indicate the location of the amino acid transporters in target tissue and the site's increased activity of the amino acid transporters," said Oka. Schust...News tips from the Journal of Neuroscience
...sporter 2 (VGLUT2). VGLUT2, one of three mammalian transporters responsible for the uptake of glutamate into synap...tsynaptic responses, indicating that the number of transporters controls vesicular glutamate content. Although heterozygous mice responded normally to a battery of ...Three UCSF faculty elected to Institute of Medicine
... out of cells. Her research focuses on the role of transporters in drug disposition. Giacomini is a leader in the ...ne if variations in the genes of people's membrane transporters affects their sensitivity or resistance to drugs used to treat a variety of diseases, including canc...News tips from the Journal of Neuroscience
..., Randy D. Blakely, and Louis J. De Felice Choline transporters (CHTs) are concentrated at cholinergic nerve termi...also transport ACh at high concentrations, and the transporters are highly expressed on presynaptic vesicles, transmitter could leak from ACh-containing synaptic ve...Single genetic defect produces specific cognitive deficit in mice
...sporter gene or to have reduced levels of it. Such transporters normally retrieve acetylcholine that one neuron has used to trigger another and transport it to storage sacs called vesicles that are the reservoir for neurotransmitter for subsequent use. The researchers found that such transporter-deficient mice we...Metal homeostasis research in plants will lead to nutrient-rich food and higher yielding crops
...tion of various mutants is shedding light on which transporters influence the distribution of important nutrients such as Iron in the seed. Such information should aid the development of nutrient-rich seed, beneficially affecting human nutrition and health. This research should also lead to agronomic benefits su...News tips from the Journal of Neuroscience
...ic transporter. The crystal structure of glutamate transporters suggests that the extracellular face is a water-filled bowl with glutamate binding sites sitting at the base. This week, Torres-Salazar et al. provide data suggesting a cooperative interaction of subunits in the generation of EAAT4 anion currents. Th...Genetically altered mice no longer like cocaine
...to and out of neurons. But cocaine blocks dopamine transporters from taking up dopamine, leaving it outside the ce...ups the normal mice and the animals with modified transporters served as controls and were given only saline injections throughout the experiment. Individual mice...JCI table of contents, May 18, 2006
...loited the finding that type 2 vesicular monoamine transporters (VMAT2) are expressed in human islet beta cells within the pancreas, as well as in tissues of the central nervous system. As the radioligand [11C]Dihydrotetrabenazine (DTBZ) binds specifically to VMAT2 and is currently used in clinical imaging of the...New study reveals structure of E. coli multidrug transporter protein
...hrough the expulsion of drugs by integral membrane transporters like EmrD. Determining the structure of this trans...s to the Major Facilitator Superfamily, a group of transporters among the most prevalent in microbial genomes. These transporters are distinctive in their ability t......n her work, she found that two of these "pumps" or transporters AcrAB/TolC and NorE actually export as yet unidentified signals used in cell-to-cell communication....