Gene associated with breast cancer may play major role in prostate cancer recurrence
...xoSmithKline) is currently in an advanced clinical trial involving patients whose breast cancer is driven b...s provides the rationale for initiating a clinical trial of this novel drug inhibiting HER-2, which is being planned for patients within several months," Wha...Alzheimer's cognitive decline slowed
... had volunteered for the study. The human clinical trial was undertaken following extensive studies in primates conducted by Tuszynski and colleagues, which showed that grafting NGF-producing tissue into the brains of aged monkeys restored atrophied brain cells to near-normal size and quantity, and also re...Stem cells from brain transformed to produce insulin at Stanford
...to mature into insulin-producing cells. After some trial and error, they found the right combination and sequence. The end result was a dish full of cells that could produce insulin and release it in response to sugar added to the environment. These cells don't perfectly mimic human islet cells. Kim's cell...Hopeful results from interrupted Alzheimer's vaccine study
...ng to recruit participants for a phase II clinical trial to test a new Alzheimer's immunotherapy vaccine st...eth Pharmaceuticals. Results from the interrupted trial show that on the whole, study participants whose immune systems mounted a response against beta amyl......wed these cues. If a forget cue was presented, the trial ended after the delay, and no memory test was given. If the remember cue was presented, the birds were given a memory test in which they saw two stimuli after the delay; if they responded to the sample stimulus (by pecking on a key), they were reward...Drug lowers inflammatory markers associated with risk for heart attack
...and was shown to be safe and well-tolerated. The trial included MI patients who carry at-risk variants in... from our MI gene-isolation study and the clinical trial reported herein show that DG-031 is a safe and well-tolerated drug that affects a biochemical defect...Clincal trials indicate NEXIUM can reduce upper GI symptoms in patients using NSAIDS
...) and 2.03 (40 mg) vs. 1.64 (placebo) in the first trial (p<0.001), and 2.17 (20 mg) and 2.12 (40 mg) vs. 1.56 (placebo) in the second trial (p<0.001). For patients on COX-2 inhibitors, the mean change was 2.21 and 1.92 vs.1.64 in the f...Concurrent radiation, chemo, followed by surgery lengthens lung cancer patients survival
...Institute-sponsored North American Lung Intergroup trial 0139. Albain serves as the medical oncology study chair for the landmark Phase III trial, the only study of its kind in the world. Participating in the study were 396 patients with stage IIIA N2 non-small cell lung cancer (NSCLC). Researchers di...Phase III clinical program evaluates lubiprostone
...t program will include two phase III trials. Each trial will examine more than 500 patients for 12 weeks to evaluate the safety and efficacy of lubiprostone. "Irritable bowel syndrome is a condition that can impact a person's quality of life, but is currently addressed by few available therapies," said ...Study finds medication prevents travelers' diarrhea
...e manage this disease," DuPont said. The clinical trial reported this week followed 210 U.S. students studying Spanish in Mexico during the summer of 2003. Only 14.74 percent of those who took a daily dose of rifaximin for two weeks suffered from diarrhea, while 53.7 percent of those who took placebos ca...Data confirm panitumumab single-agent antitumor activity in patients with mCRC
...nal data from a Phase 1 open-label dose escalation trial were presented by Louis M. Weiner, MD, chairman, department of medical oncology, and vice president, translational research at Fox Chase Cancer Center, Philadelphia, Pa. Exposure and tolerability profiles were similar between weekly, every-other-wee...New kidney test better elder mortality predictor
...research, Shlipak would like to conduct a clinical trial to determine if cystatin C is truly effective as a diagnostic tool. "We need to prove that before we can recommend that people use it."...OneWorld Health drug receives 'Orphan' designation from U.S. and European regulatory agencies
...al parasites. The largest-ever Phase III clinical trial for visceral leishmaniasis was completed in Novemb...World Health Organization (WHO/TDR). The clinical trial used the injectable form of paromomycin in 667 patients in India....New data demonstrate that Benicar and Benicar HCT significantly reduces systolic hypertension
...k, prospective, open-label, multicenter, titration trial conducted in the United States. The study sample ...cond study was a 24-week, multi-center, open label trial utilizing a BENICAR-based treatment algorithm to determine its efficacy in getting Stage 1 and Stage...Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
...ve baby with her own eggs," Smith says. A clinical trial through the U-M Comprehensive Cancer Center is planned to begin by fall....Other highlights in the June 1 JNCI
...ucted a phase III double-blind, placebo-controlled trial of UDCA in 1,285 patients who had undergone removal of a colorectal adenoma. The participants were randomly assigned to received UDCA treatment or a placebo for 3 years or until a follow-up colonoscopy. UDCA treatment was associated with a 12% reduct...Scientists use gene transfer technology and common virus to block neuropathic pain
...cientists plan to conduct the first phase I safety trial of a related HSV vector in patients with pain caused by terminal cancer, which has spread to bone....Vaccine targets tumors where they live
...al setting. The data represent the first clinical trial to directly inject a vaccinia virus expressing the B7.1 costimulatory molecule into humans with melanoma. The researchers show that this vaccine is safe and feasible to use for local delivery into established melanoma lesions. 2 of the injected les...JCI table of contents July 1, 2005
...al setting. The data represent the first clinical trial to directly inject a vaccinia virus expressing the...t HIV infection is controversial despite the first trial having been completed ten years ago. While it is established that IL-2 therapy increases the CD4+ T ...Researchers develop gene therapy to reverse pulmonary arterial hypertension
...ndrial diseases, the team is initiating a clinical trial in human PAH. Similarly, newer drugs that inhibit Survivin, currently in trials in oncology, might also be directly applicable to PAH patients, Dr. Michelakis explains. The researchers are supported by the Canadian Institutes of Health Research and C...