Results of world's first gene therapy trial for arthritis show approach safe, feasible
...huttles a gene into cells as a more recent French trial for X-linked severe combined immunodeficiency (X-S...r antagonist, or IL-1 Ra. Because it was the first trial of its kind and safety was a key concern, the protocol was designed so that the gene would be delive......s in the US could soon be asked to approve a human trial of gene therapy for cystic fibrosis that uses a hy...soon." Kobinger now plans a more extensive monkey trial to convince the US Food and Drug Administration that human trials will be safe. The hybrid virus is ...Treating pregnancy-related diabetes is a win-win for mum and baby
...ls to be certain they do more good than harm. "Our trial known as the ACHOIS - Australian Carbohydrate Into... difficulties during birth and birth injuries. The trial was designed by a group of researchers from the University of Adelaide departments of Obstetrics and...Phase I study examines biomarkers for response to erlotinib in glioma
...r tissue samples from 41 participants in a phase I trial in which glioma patients were treated with erlotinib either alone or in combination with temozolomide. The tumors were examined to determine whether the expression of EGFR and its related proteins were associated with response to erlotinib. Eight of ...Lance Armstrong through a physiological lens: hard training boosts muscle power 8%
...trong's "freely chosen cycling cadence during time trial races of 30- to 60-minute duration increased progressively during this y-year period from about 85-95 rpm to about 105-110 rpm. This increase in freely chosen rpm when cycling at high intensity is indeed consistent with increase in type I muscle fibe...Recurrent miscarriages: Could prednisolone reduce the occurrence of this distressing condition?
...roduction and Embryology: "A randomised controlled trial of prednisolone for the prevention of miscarriage is urgently needed and I am in the process of setting one up." However, Dr Quenby, who is a senior lecturer and honorary consultant in the Department of Developmental and Reproductive Medicine at the...Positive effects of nuclear medicine, 'smart drugs' provide hope for non-hodgkin's lymphoma patients
...iologie, INSERM, Nantes, France. "This multicenter trial is also evaluating the safety and efficacy of this agent in a continuing dose-escalation trial," added the SNM member. Chatal commented, "Radioimmunotherapy has already been introduced into the management of indolent non-Hodgkin's lymphoma patients ...Michael R. Zalutsky named recipient of Society of Nuclear Medicine's 2005 Berson-Yalow Award
...icrodosimetry and initiation of the first clinical trial with an astatine-211 labeled, targeted radiotherapeutic. His research has been supported by a grant from Genentech as well as multiple grants from the National Institutes of Health and the Department of Energy. Zalutsky and his colleagues were commen...Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
...headlines and at medical conferences. The clinical trial of this Akt-inhibitor is a concrete step toward that reality. Sebti says, "The beauty of this trial is that it's molecular therapy, based on the blueprint of the tumor cell."...$7.3 million NIH grant establishes Wellstone Muscular Dystrophy Research Center at the UI
...anced diagnostic services to patients and clinical trial participants. "The Wellstone Centers promote basic...atients, and examine muscle biopsies from clinical trial participants to evaluate new treatments. Core C, directed by Yang and Roger Williamson, M.D., UI pro...MIT develops 'Anklebot' for stroke patients
... trials involving almost 300 stroke patients. Each trial addressed different questions, such as the short- ... control group," Krebs said. At the same time, the trial showed that the robot is well tolerated by patients and causes no pain. The new center at the Baltim...UF researchers test drug that could cut orthodontic treatment time in half
...e," Wheeler said. "This initial proof of principle trial will help us define how to accomplish that."...Urine test may help monitor disfiguring birthmarks
...treatments." Fishman is now conducting a Phase I trial of MMP inhibitors in nine patients with vascular malformations that have not responded to, or are not candidates for, the current treatments. Two other patients have been receiving MMP inhibitors under compassionate-use protocols. In the meantime, ur...Women's health study finds vitamin E does not protect women from heart attack, stroke, or cancer
...rom the Women's Health Study, a long-term clinical trial of the effect of vitamin E and aspirin on both the...e National Institutes of Health. "This landmark trial has given women and their physicians important health information. We can now say that despite thei...Other highlights in the July 6 JNCI
...tin), according to a new study. A recent phase III trial showed that the addition of bevacizumab, a monoclo...g, Colorectal, and Ovarian (PLCO) cancer screening trial found a high acceptance of flexible sigmoidoscopy screening and indicate that the trial's eventual r...New treatment extends survival for patients with advanced lung cancer
...Toronto July 13, 2005) An international clinical trial led by Canadian researchers has demonstrated that ...will die of the disease. The lung cancer clinical trial was coordinated by the National Cancer Institute of Canada Clinical Trials Group, which is funded by...Joslin-chaired study shows new compound may decrease vision loss in diabetes
...iabetes. Initial results of the Phase III clinical trial demonstrated that 32 milligrams per day of ruboxistaurin (RBX) was well tolerated and may reduce the risk of moderate vision loss, especially in patients with diabetic macular edema. Loss of vision is a common complication of diabetes and results fro...Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy
...d for 24 hours to 72 hours in a phase III clinical trial for patients with sickle-cell anemia, but questions about the safety of long-term use remain. "If issues of dosing and long-term safety can be resolved, our research suggests that poloxamer 188 could be a new therapeutic agent for preventing or limi...Compound from Chinese medicine shows promise in head and neck cancer
...lthy tissue. Researchers hope to begin a clinical trial in head and neck cancer patients within a year, testing whether (-)-gossypol can be used along with chemotherapy to create a better response and avoid surgery. More than 29,000 people will be diagnosed in 2005 with head and neck cancers, which inclu...Insulin spares intensive care patients from organ failure and death
...eviously shown, in a large, randomized, controlled trial that controlling blood glucose with insulin reduces the risk of organ failure and death of patients in intensive care. But the underlying mechanisms explaining these clinical benefits remained incompletely understood. In a new study appearing on A...