JCI Table of contents August 1, 2005
...eviously shown, in a large, randomized, controlled trial that controlling blood glucose with insulin reduces the risk of organ failure and death of patients in intensive care. But the underlying mechanisms explaining these clinical benefits remained incompletely understood. In a new study appearing on A...Ethanol treatment may be instrumental in fighting IV-based infections
...ed with a large-scale ongoing comparative clinical trial Maki and Crnich are conducting at UW Hospital to rigorously test the ethanol lock's capacity to prevent IV catheter-related bloodstream infections. Together, the research projects ultimately will provide "essential results" that may enable medical pe...Old drug, new tricks: Prospects for slashing the impact of malaria
...act of malaria is in prospect with a clinical drug trial to begin in Papua New Guinea early next year. Success in the trial would open the way to relief in the 10% of humanity infected with this debilitating and often fatal ...New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
...mily history and antibody testing. At present, the trial is enrolling only at-risk individuals who have alr...ividuals interested in more information about this trial should contact Jason Gaglia at Joslin Diabetes Center at 617-732-2481 or jason.gaglia@joslin.harvar...New type of rejection blocker protects kidneys after transplant
... UCSF Medical Center. "This is the first clinical trial of a treatment for transplant recipients based on ...led the first patient to receive belatacept in the trial early in 2001. Twenty UCSF patients have been taking the drug for more than three years. "So far, re...Major advance in the treatment of severe malaria in our region
...f thousands of lives in nations on our doorstep. A trial in malaria patients from four countries has shown ...ch in Darwin, Australia, which participated in the trial in partnership with the Indonesian Ministry of Health. The regional collaboration between the Indone...Blocking a premature aging syndrome with anticancer drugs
...ts in cultured cells in the laboratory, a clinical trial of these drugs in HGPS children may begin as early as next spring. Brian Capell, a New York University medical student participating in the Howard Hughes Medical Institute/National Institutes of Health Research Scholars Program and the first author ...Anti-cancer drugs may hold promise for premature aging disorder
...mprovements in the animals' conditions, a clinical trial of FTIs in children with progeria may begin as early as next spring, researchers said. Dr. Collins and his colleagues discovered in April 2003 that mutations in the lamin A (LMNA) gene cause progeria, spurring renewed interest among researchers to s...Study shows humans have ability to track odors, much like bloodhounds
... tell you how accurate he or she would be on every trial and on the task overall," Sobel said. "So the fact that we have this predictive value in the data really suggests that we have actually successfully captured the mechanism." What's more, another area of the brain outside the olfactory cortex was very...Where bonehead investments come from
...stocks and a bond by pressing buttons. Before each trial run, the researchers "showed them the money," telling the subjects that they would receive a percentage of the cash that they made by investing or would lose cash from their participation fee if they were not successful. Without telling the subjects,...A picture of progress: PET imaging and biomarkers explored at ACS meeting
...A Speedier Trial To design a randomized clinical trial of a new therapy, a pharmaceutical company often w...aging was used to design a more effective clinical trial of a cancer therapy by characterizing and tracking a tumor in vivo. A similar technique, if taken in...Canadian-led study shows amnioinfusion does not reduce risk of meconium aspiration syndrome
...methods and international scope of this randomized trial (56 study sites in 13 countries) provides very str...ed that it is not effective in this context. This trial did not examine amniofusion in other contexts. Thorough, large scale studies are needed before drawi...Acute-leukemia sign may signal need for different therapy
.... The study is part of a larger CALGB cytogenetic trial chaired by Clara D. Bloomfield, professor of internal medicine and the William G. Pace III Professor in Cancer Research, OSU Cancer Scholar and senior adviser to the OSU Cancer Program. "It's widely believed that AML cases with these abnormalities h...University of Kentucky awarded $6 million for GDNF and related research
...k patients enrolled in a national Phase 1 clinical trial for the drug were left without medical treatment o...ker for the corporation. Shortly after halting the trial and withdrawing all GDNF treatment from patients, Amgen applied for a new patent on a different form...DFG to fund nine clinical trials
... be funded by the DFG are as follows: The clinical trial Spiral CT Scanning for the Early Detection of Lung...eeding also represent numerous risks. The clinical trial "Covered Transjugular Intrahepatic Portosystemic Stent Shunt versus Optimized Medical Treatment for ...Breast tumors in mice eradicated using cancer vaccine
... vector is currently being prepared for a clinical trial targeting a tumor antigen associated with cervical cancer by Advaxis Inc., a cancer vaccine biotech company that has licensed Penn patents on the use of Listeria monocytogenes as a vaccine vector. Paterson is the scientific founder of Advaxis and Cha...Cytokinetics presents data on CK-1827452
... subject of a first-time-in-human Phase I clinical trial designed to evaluate the safety, tolerability, pha...7452. The recent initiation of a Phase I clinical trial for this drug candidate is an important step forward for Cytokinetics and this program." Developmen...Hanging baskets of sex and death help fruit growers
...East Malling Research on a larger scale 12 hectare trial of the dispenser in a large commercial apple orchard in Worcestershire. An array of 25 dispensers per hectare have been erected over 3 separated orchard plots of one hectare within an even larger orchard. The codling moth control within these three...Other highlights in the September 21 JNCI
...tive. The Women's Health Initiative, a randomized trial in which more than 16,000 women received either estrogen plus progestin or a placebo for the treatment of menopausal symptoms, found that women given the hormones were more often diagnosed with breast cancer and were diagnosed with cancers at more ad...Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease
Neurologix's Phase I trial showed positive interim results in patients with P...erim results of its landmark gene therapy clinical trial for patients with Parkinson's disease. Neurologix's 12-patient, dose-escalating Phase I trial is th...