Updated data on novel HPV vaccine confirms efficacy in large population
... and the most common adverse event reported in the trial was local discomfort at the injection site. The study is part of an ongoing phase III program involving more than 25,000 people in 33 countries. For the FUTURE II study, a prospective, randomized, double-blind, placebo-controlled study, women aged ...New European legislation impacts on both cancer trials and drug approval
...onduct of academic clinical trials in the European trial space. In addition, radiotherapy studies, trials i...estigating surgical techniques and some multimodal trial concepts remain out of the scope of the revised legislative texts in some cases. In certain member s...New treatment options for patients with prostate cancer
...terdam, Professor Harry Bartelink commented, "This trial demonstrated that for radiotherapy of prostate can...red safely. The consequence of this first analysis trial is that the standard treatment for prostate cancer should change to a higher radiation dose, as we p...ECCO 13 - Sunitinib prolongs survival in GIST patients after imatinib mesylate failure
...3 November 2005 - Updated results from a Phase III trial presented at the 13th European Cancer Conference (...-controlled, international, multicentre, Phase III trial involving 312 patients with GIST whose cancer had progressed despite previous treatment with imatini...Genetic analysis of glioblastoma brain tumors can aid in treatment decisions, study shows
...blastoma patients who had taken part in a clinical trial of erlotinib at the University of California, San Francisco. The findings suggest that both EGFRvIII and PTEN proteins are important for tumors to be susceptible to EGFR inhibitors, Dr. Mischel says. Their data further suggest that EGFRvIII may act ...New screening test proves earlier, more accurate predictor for Down syndrome
... 10, 2005 issue), the study is known as the FASTER trial (First and Second Trimester Evaluation of Risk). It was funded by a $13 million grant from the National Institutes of Health and the National Institute of Child Health and Human Development one of the largest ever grants for an obstetrical study. T...AACR-NCI-EORTC international conference
... Researchers are about half-way through a clinical trial that uses pulses of electricity to deliver a gene for a powerful immune system stimulant to tumor cells. This patient study is the first to test "electroporation," or electrical stimulation, to deliver to humans a plasmid that contains all the genet...Rutgers' Wise Young named to Esquire's 'Best and Brightest of 2005'
...d on stem cells, from the laboratory into clinical trial as quickly possible," Young said. "A cure is possible for spinal cord injuries, and collaboration is the means by which that goal can be reached." Young's collaborative spirit fits well with Rutgers' institutional strategy. University scientists are...'Creationism is not science' making the case for Darwin at UCL
...Pennsylvania will take their local school board to trial over the introduction of Intelligent Design into the school's curriculum. The outcome of that will surely go down in the history books."......tatement notifying the failure of a large clinical trial of gefitinib to show an overall survival advantage...e Iressa Survival Evaluation in Lung Cancer (ISEL) trial is a large randomized trial conducted in 1,692 patients with refractory NSCLC who received either ge...New results show the RTS,S malaria vaccine candidate protects children for at least 18 months
...wed, and MVI and GSK--with CISM and other clinical trial partners in Africa--will continue clinical development of the RTS,S/AS02A vaccine. In October, the Bill & Melinda Gates Foundation announced a $107.6 million grant to MVI to support this work. "The ability of this vaccine to protect children from sev...Innovative research set to push boundaries of cancer care
...lorida are almost mid-way through a human clinical trial that uses pulses of electricity to deliver a plasm...ng for IL-12 to melanoma tumor cells. This phase I trial will enroll approximately 18-30 patients with advanced melanoma at five dose levels. The current dos...New antimalarial combination confirms its potential use in treating drug-resistant malaria
...artemisinin containing combinations." The phase II trial of CDA, involving adults and children with P. falciparum malaria, was designed to determine the optimum dose of artesunate in combination with LapdapTM (chlorproguanil/dapsone). Treatment with CDA, at three doses of artesunate (1, 2 and 4mg/kg) in ad...Recycled or revamped therapeutics find novel anti-cancer applications
...ibutes to enhanced immune response. In a Phase II trial conducted by Amato and colleagues, the study inclu...s 59 percent." Patient response to toxicity of the trial drug regimen was contained to predominantly grade 1 or 2, Amato said, manifested predominantly in tr...Studies show apo A-I Milano gene transfer and antibody therapy cut atherosclerotic plaque
...Based on the results of Shah's studies, a clinical trial was conducted in humans with similar results. After five weeks of once-a-week injections, apo A-I Milano significantly shrank plaque in coronary arteries. The protein appeared to actually remove bad cholesterol, even from sites on arteries where plaq...Scientists evaluate impact of preemptive malaria treatment for infants
...PTi) will explore the results of a recent clinical trial in Ghana and preliminary evidence from other IPTi ... opportunity to discuss the results from the Ghana trial and other IPTi studies with the international malaria research and control communities. We aim to b...ADHD medication might also treat hyperactivity symptoms in autism
...igators conducted a randomized, placebo-controlled trial to determine whether methylphenidate would be effe...n reducing hyperactivity in children with PDD. The trial included a one-week test phase to ensure that subjects could tolerate three different dose levels of...You can't rely on firearms forensics
...at Baltimore police found on his left hand. At his trial for murder in 1998 the crime-lab examiner gave evidence that the particle was residue from a gunshot. He claimed Jones must have held or fired a gun shortly before his arrest. Jones denies this and still protests his innocence. His defence team is ap......eted a randomized, double-bind, placebo-controlled trial of zinc supplementation at an urban hospital in Pietermaritzburg, South Africa. The 96 children in the study were cared for on a monthly outpatient basis by a team of medical doctors and nurses. Parents were taught how and when to give the 10-mg zinc...