First link found between obesity, inflammation and vascular disease
...ls by themselves produce inflammatory signals that trigger cells to produce CRPs, and if CRPs also produce biological effects on vascular walls, that could explain the higher risk of cardiovascular disease." The investigators then solved the other part of the puzzle why it is that aspirin, statin drugs and ...Researchers identify new target in fight against obesity
...they actually work through independent pathways to trigger a molecule that turns on S6K1. "Since we know S6K1...ngly sealed its own fate by shutting down the very trigger that turns it on. In single-cell organisms, said Dr. Thomas, feeding is the organism's main concern....Diamonds are a doctor's best friend
...compatible and unlike other types of coating don't trigger the coagulation of blood. Franks reported that they have already provided surgeons at the Royal National Orthopaedic Hospital (RNOH) with DLC-coated knee implants for patients allergic to the metal used. Professor Joe Franks said: "We've also develo...Bleach found to neutralize mold allergens
...for removal since dead mold retains its ability to trigger allergic reactions, according to Dr. Martyny. The researchers grew the common fungus Aspergillus fumigatus on building materials for two weeks, and then sprayed some with a dilute household bleach solution (1:16 bleach to water), some with Tilex Mold...JCI table of contents October 1, 2005
... PAF Staphylococcus aureus infections of the skin trigger inflammatory skin diseases, including atopic dermatitis. But the mechanisms by which this bacteria can modulate the immune system are not entirely clear. In a paper appearing online on September 22 in advance of print publication of the October 1 i...Temperature regulates circadian clock in zebrafish
...iri et al. show, and precise shifts in temperature trigger significant changes in the expression of specific ...ant temperature. Acute temperature shifts can also trigger significant changes in clock gene expression (transcript levels of per4 and cry3 dropped after a tem...MSU researchers receive $4 million grant to uncover gene functions
...hich encode the chloroplast-targeted proteins that trigger photosynthesis. Understanding how these genes operate could yield significant breakthroughs in biotechnology and genomics worldwide, resulting in advances in human health and agriculture. The chloroplast gives green plants their color and carries out...Fruit fly studies open new window on cancer research
...es the sensitivity of a cell to a hormone that can trigger abnormal growth and cancer. Their discovery could lead to a completely new approach to tackling some cancers and the development of new drugs to stop uncontrolled growth in a wide variety of tumour cells. The researchers at the University of Oxford, ...New research could help us deliver genes for new bone formation
...ive combinations of genes and delivery scaffold to trigger the highly complex process of bone formation. The technique, if successful, could provide a new source of bone tissue for orthopaedic procedures. Professor Richard Oreffo, who is leading the team at the University of Southampton, said, "The key to th...Say what? Bacterial conversation stoppers
...idual microbe going it alone. Swelling populations trigger their quorum-sensing apparatuses, which have different effects in different types of bacteria. One species might respond by releasing a toxin, while another might cut loose from a biofilm and move on to another environment. Each species of bacteria h...Study offers clues to origins of autoimmunity
...uld activate this dangerous B cell and cause it to trigger an autoimmune disease. "There have been reports linking the onset of autoimmunity with a preceding bacterial infection," said Stephen Gauld, Ph.D., lead author and post-doctoral fellow in Dr. Cambier's lab. "We are now conducting experiments to deter...Molecular research suggests shift needed in how some drugs are created
...nnect properly. A tight connection is necessary to trigger an immune response. A mammalian counterpart for Drosophila's Tube molecule has not been found, but Lasker and Nair theorize that adaptors that bind IRAK-4 will either bind at a different site, or the adapter molecule will have an interface that can h...JCI table of contents October 3, 2005
...S13 deficiency is necessary, but not sufficient to trigger the symptoms that are characteristic of TTP. They demonstrate that the microbial toxin, Shigatoxin triggers a syndrome in susceptible mice that is remarkably similar to human TTP. The authors identify genetic susceptibility factors required for TTP...First big influenza genome study reveals flu evolution
...sia, will jump the species barrier into humans and trigger a new pandemic. Although researchers first isolated the influenza virus in 1933, they still don't fully understand how the virus evolves. Influenza is an RNA virus that contains eight separate RNA segments encoding genes for at least 11 proteins. T...Feedback loop found that could forestall liver disease
...f the acids. When enough bile acids are made, they trigger a series of reactions that blocks the gene for CYP7A1, and production stops. For this study, UT Southwestern researchers looked at a protein in mice called fibroblast growth factor 15 (FGF15), which is part of a cascade of chemical reactions that al...Muscle of obese 'programmed' to amass fat, genetic study finds
...ns suggest that transient environmental stress can trigger permanent alterations in metabolic control. Thus, our findings could reflect an epigenetic phenomenon in which obesity-induced modifications in gene activity provoke irreversible perturbations in SCD1 gene regulation." "While these findings may be so...University of Delaware researchers develop cancer 'nanobomb'
...optical and thermal properties, and found we could trigger microscopic explosions of nanotubes in wide variety of conditions." Explosions in air of loosely packed nanotubes have been seen before in an oxygen environment, creating ignition. However, the work reported by Panchapakesan uses the localized ther...Rapid genomic and physiological responses for social dominance
...of egr-1 in the anterior preoptic area is an early trigger in a molecular cascade that ultimately produces the physiological changes associated with dominance in cichlids. Given that the preoptic region and GnRH are highly conserved in vertebrates, a similar neural mechanism could link social status to sexua...Sudden change in social status triggers genetic response in male fish, study finds
...direct evidence that changes in social status also trigger cellular and molecular changes in the brain, he ad...s to figure out exactly how social information can trigger a genetic response that results in such a profound change in an animal's appearance and behavior. ......in making copies of itself into messenger RNA that trigger protein production. In their experiments, the researchers studied a process called "chromatin remodeling"--in which the histone proteins enfolding genes are chemically altered to render the genes active. They administered to rats both short-term, acu...