Aging affects susceptibility to type 2 diabetes
...d provide an explanation by which an environmental trigger like aging modifies genetic susceptibility to type 2 diabetes. In an accompanying commentary, Alan R. Shuldiner and John C. McLenithan from the University of Maryland School of Medicine discuss these results and how aging, diet, exercise, and othe...How the battle of Waterloo could help doctors fight death from multiple organ failure
...jurious to the healing process. "Modern treatments trigger changes in the patient's inflammatory and immune responses or influence circulatory, hormonal, bioenergetic and metabolic systems in ways we don't appreciate. Even lowering the temperature of a feverish patient may be counter-productive. We may need ...Genetic discovery paves way to decode sense of smell in mammals
...tein switches nestled in nerve cell membranes that trigger responses to specific volatile chemicals. The discovery of the chaperone proteins reveals the first molecular components of the olfactory machinery that promotes proper targeting of olfactory receptors to the neuronal cell surface, said Hiroaki Ma...Citrus shows promise for certain childhood cancer
...blocker did not die, indicating that the limonoids trigger apoptosis which in turn results in the cell death. In their tests, the cancer cells treated with limonoids but not the apoptosis blocker all died within 36 hours. The researchers also looked at caspases, destructive enz...Fussy Baby Network answers cries for help in community
...to chaos. "Persistent, inconsolable crying is a trigger for child abuse in the first year of life," Gilker... cycle of mother/infant distress. Crying is both a trigger and a response. "If the mother is feeling overwhelmed or exhausted, or suffering from post-partum de...JCI table of contents, December 1 2004
...e, bax relocates to the mitochondrial membrane and trigger cell signaling events that lead to cell death. Administration of PGE2 to radiation-exposed mice was found to activate AKT phosphorylation events that block the relocation of bax within the cell, and therefore prevent cell death. The data suggest that...Researchers discover direct link between agricultural runoff and massive algal blooms in the sea
...d if each fertilization and irrigation event would trigger a noticeable phytoplankton bloom near the mouth of the Yaqui River, which is located on the mainland side of the Sea of Cortez. To find out, the researchers analyzed a series of images from an orbiting NASA satellite called SeaWiFS, which is equipped...Genetic defect confers risk of major depression, resistance to SSRI drug therapy
...signals from one end to the other. One neuron will trigger an impulse in others by launching bursts of chemical neurotransmitters, including serotonin, that set off an impulse in receiving neurons. Once the original cell has passed its message on, it sops up the chemical it released to dampen that signal and...Researchers show how botulism toxin ensnares its target
...se to fire bursts of neurotransmitter chemicals to trigger neighboring nerves or activate muscle cells. Without SNAREs, nerve function is blocked. Neurotoxin proteases that act by cleaving SNARE proteins are highly specific for their targets meaning that each toxin specifically recognizes and attacks one of...Dwarf mistletoe reveals its sexual secrets
...n of the egg and its accessory cells is thought to trigger a chemical signal that causes the pollen tube to find the egg and fertilize it. But with my dwarf mistletoe, the pollen tube, which contains the plant's sperm, grows down through the young flower and reaches the area where the egg is going to be long...NASA finds trees and insect outbreaks affect carbon dioxide levels
...roughts and heat waves in North America, which can trigger large seasonal losses of carbon dioxide back to the atmosphere." Potter added. NASA scientists report a satellite-driven computer model that predicts forest re-growth conservatively projects that 0.3 billion metric tons of carbon could be 'stored' ea...Alcohol vulnerability linked to action of insulin
... receptors that docks with the insulin molecule to trigger the normal signaling function. They found that in all cases, the mutant flies showed increasing alcohol sensitivity, leaving little doubt that the insulin pathway normally functions to regulate the degree of alcohol intoxication. The key part ...NSF funds Panikov's Alaskan Tundra Microbial Observatory project
..." The Alaskan tundra was found to be an important trigger in recent global climatic changes: warming caused degradation of permafrost and stimulated microbial decomposition, converting the tundra from a 'sink' to a net source of CO2-to-atmosphere. The understanding, prediction and mitigation of the observed...JCI table of contents, December 15 2004
...ajor source of ROS in obesity and acts as an early trigger of the metabolic syndrome. While it is too early to suggest that taking antioxidants may counter the development of obesity-associated metabolic syndrome, the steps leading to excess ROS generation may represent a potentially useful therapeutic targe...Oxidants link obesity to diabetes
...ajor source of ROS in obesity and acts as an early trigger of the metabolic syndrome. While it is too early to suggest that taking antioxidants may counter the development of obesity-associated metabolic syndrome, the steps leading to excess ROS generation may represent a potentially useful therapeutic targe...Where the brain harbors unconscious fears
...of fearful faces has been shown in many studies to trigger a fearful response in people. In the commonly used brain imaging technique of fMRI, harmless magnetic fields and radio signals are used to measure blood flow in brain regions, which reflects brain activity. In their experiments, the researchers first...Shots fired at Bayonne range prove smart gun technology works
...f the users' hand during the first second when the trigger is squeezed. "This technology is similar to how electronic machines read an individual's signature upon completing a credit card transaction," said Sebastian. The next step is for NJIT researchers to turn over their invention to the Australian-...Researchers discover a stem-cell switch lurking within leukemias
...ce. In contrast, BCR-ABL by itself was unable to trigger such proliferation. "In the case of MOZ-TIF2 and...o switch on these same programs in normal cells to trigger tissue regeneration and, although it's something of a pipe dream, perhaps even organ regeneration."...Blocking cell suicide switch fails to stop prion damage in mouse brains
...at other scientists had previously identified as a trigger of apoptosis in central nervous system cells. Harris and his colleagues crossbred the mouse prion model with a line of mice where the Bax gene had been deleted. As they expected, cerebellar granule neurons survived in mice that both had the prion mut...... blood vessels and recruitment of microglia helped trigger tumor formation or if they appeared only after the tumor was fully developed. The researchers found that by three weeks of age, the mutant mice had about four times the number of small blood vessels in the optic nerves and chiasm as control mice. Sim...