Brain tumor study reveals why treatment efforts fail in genetic disorder
...ctively activating K-RAS. Activating H-RAS did not trigger the cascade. "Though K-RAS doesn't respond well to available chemotherapy drugs, one of the proteins it interacts with might," Gutmann says. "By showing that K-RAS activates a pathway that is unique from the pathways activated by other RAS molecules...JCI table of contents, 3 January 2005
... pathogens, nor do they produce the molecules that trigger the inflammatory response. These characteristics distinguish intestinal macrophages from their precursors blood monocytes and indicate that highly proinflammatory monocytes travel to the intestine in response to injury but upon arrival they acquire...Stem cell therapy for ailing hearts
...eart muscle cells or secreting growth factors that trigger the heart to repair itself? We need more research to insure such therapy will ultimately benefit patients with little or no side effects." "The possibility to regenerate and to restore function of the heart after myocardial infarction with stem cell ...Surprising study reveals how cancer-causing protein activates
...etitive research during the last decade. One known trigger is phosphorylation, which modifies some of the tyro-sine and serine amino acids that make up the STAT3 protein. Chin and his team found a second trigger: acetylation, another chemical process that modifies amino acids, such as lysine. Chin said this ...Enzyme allows B cells to resist death, leading to leukemia
...an undefined defect in the programmed signals that trigger normal B cell death (apoptosis). Livio Trentin and colleagues from Padua University School of Medicine now demonstrate that high levels of expression and altered cellular location of an enzyme in B cells known as Lyn, contributes to the development o...COX-2 levels are elevated in smokers
...ced more amphiregulin and TGF-alpha, both of which trigger EGFR function. "Cellular release of both of these EGFR ligands occurred quickly after exposure to tobacco smoke," Dannenberg said. These findings appear to be directly relevant to people because increased levels of both proteins were also detected i...New evidence indicates biggest extinction wasn't caused by asteroid or comet
...zen on the ocean floor might have been released to trigger runaway greenhouse warming, Ward said. But evidence suggests that species began dying out gradually as the planet warmed until conditions reached a critical threshold beyond which most species could not survive. "It appears that atmospheric oxygen l...The Cochrane Library Newsletter, 2005, Issue 1
...ing it to children. In addition, mass use tends to trigger populations of rifampin-resistant bacteria. The Cochrane authors found that ciprofloxacin and ceftriaxone are as effective as rifampin for eradicating carriage of N. meningitides and suggest that doctors consider using ciprofloxacin or c...Despite causes of lupus proving complex, critical 'checkpoint' suggesting new therapy is revealed
...lation of auto-antibodies (molecular "arrows" that trigger immune system assault on the body's own tissues) t...that work in concert to reach a threshold and then trigger symptoms that are self-enhanced and self-sustaining, we have shown that it may be enough to simply c...Steroid discoveries could add bulk to crop harvests
...'s team may one day lead to less expensive ways to trigger growth enhancement of plants. "The common theme of these two articles is that we are now beginning to unravel the molecular mechanisms by which steroid hormones regulate gene expression in plants," said Chory, who is at The Salk Institute for Biologi...Scientists reveal cells' 'energy factories' linked to cancer
...of a simple metabolic molecule in mitochondria can trigger a sequence of events that leads to tumour growth. The discovery increases our understanding of the molecular basis of several types of cancer, which is crucial for the development of new ways to prevent, diagnose and treat the disease. Scientists k...US government list of cancer-causing agents grows
...etimes. Research shows that environmental factors trigger diseases like cancer, especially when someone has a family history," said Kenneth Olden, Ph.D., director of the National Institute of Environmental Health Sciences and the National Toxicology Program, which prepared the report for DHHS. The Report on...Multi-purpose protein regulates new protein synthesis and immune cell development
...m. Antibodies lock on to antigens substances that trigger the immune response until they can be removed or destroyed by other immune cells. Knowing that XBP1 was required to create plasma cells, Zhang designed a study to see if IRE1 was involved, also. Zhang studied mouse embryos that were missing the ge...Key trigger of opioid withdrawal symptoms found
...mmunition that one neuron fires at its neighbor to trigger a nerve impulse in the neighbor. Propagation of su...lecules from the spaces between neurons after they trigger nerve impulse, to reload the neuron for its next signaling burst. Bagley and her colleagues also dis...Selective predation and productivity jointly drive complex behavior in host-parasite systems
...amatic behaviors diminish, but predators can still trigger large fluctuations of parasite abundance at higher productivity. Surprisingly, when predators show no preference for or even avoid parasitized hosts, interactions between the two enemies can drive both host and parasite unavoidably extinct. These fi...Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study
...onmental factors such as bacterial infections that trigger the disorder. Recently, scientists identified mutations in a gene called NOD2 as leading to 50 percent of Crohn's cases in patients of Northern European descent, but they haven't known just how NOD2 causes the severe inflammation associated with the...Study finds direct association between cardiovascular disease and periodontal bacteria
...over several decades to determine if they directly trigger heart disease, most previous studies pursued indirect evidence. These included various measures of oral and cardiovascular health, which researchers then extrapolated to the influence of the oral pathogens. Conspicuously missing from the debate has...Bird brains show how trial and error may contribute to learning
...ter program that could track the bird twitters and trigger stimulations to LMAN at precise moments to elicit measurable effects on a predetermined syllable, song after song. The researchers found that different areas of LMAN tuned the same note in different directions, one area raising the pitch of a certain...U of T researcher links schizophrenia, gene mutations
...needs." An excessively active dopamine system can trigger the hallucinations and delusions experienced in schizophrenia, amphetamine drug abuse or Alzheimer's disease. In drug abuse, the reaction is temporary; in schizophrenia, it recurs. "This research brings together two worlds: the psychosis of drug abu......the telomeres, such events may accelerate aging or trigger cancer in humans." "We have identified a molecular mechanism to explain how this enzyme helps keep telomeric DNA silenced and potentially protects the genome from destabilizing activity," says N.C. Tolga Emre, a graduate student in Berger's laborator...