Research aims to identify markers for menopausal women at risk for deadly blood clot
... occur more frequently as a result, if a change is triggered by infection, and what may account for thrombotic risk in one woman over another. The study design takes into account the researchers belief that three forces an injury, a platelet effect at the injury, and the inflammation that affects the plate...Inflammation may cause preterm labor and fetal deaths
...ry effective at preventing preterm births that are triggered by a bacterial infection. Mice, as well as humans, have several toll-like receptors (TLR) that sense the surface components of living or dead bacteria. TLR2 and 4 are key receptors in recognizing bacterial surfaces. The investigators concentrated...What we can learn from the biggest extinction in the history of Earth
...e that a massive, rapid release of carbon may have triggered this extinction. "People point to the fossil record as a place where we can learn about how our actions today may affect the future course of evolution," Payne said. "That's certainly true: The deep geologic record provides context for modern event...UCF research links proteins, stem cells and potential Alzheimer's treatment
... a hallmark of Alzheimers disease. The combination triggered the regeneration of neurons that are destroyed by Alzheimers and are necessary for healthy brain functions. The research findings were published in the July 24 edition of PNAS (Proceedings of the National Academy of Sciences). There are 5 millio...Einstein researchers' prototype vaccine could provide improved protection against tuberculosis
...ls from undergoing apoptosisthe cell suicide often triggered when microbes invade cells. For intracellular TB bacteria, avoiding apoptosis is an understandable aim: Apoptosis flushes them into the open, activating immune cells known as CD8+ T cells. These T cells make important contributions to the immune resp...Research shows NPD1 protects a key component of vision
...e team decided to explore whether oxidative stress triggered by another experimental condition, called serum starvation/H2O2/TNF,, would be similarly inhibited. NPD1 also exerted protection in this experimental condition. Addition of NPD1 even eight hours after triggering oxidative stress resulted in protectio...Boston Univeristy bioengineers devise 'dimmer swith' to regulate gene expression in mammal cells
...searchers flipped the switch, toxin production was triggered and the cell died. They also showcased the switchs capability for delicately tuning gene expression, by installing it alongside a gene that leads to apoptosis, programmed cell death, once a certain threshold concentration of the genes product is r...Is nutrient loading a smaller problem than we think?
...phication caused by elevated nutrient loadings has triggered major alterations of coastal ecosystem structure and function. A recent journal article in Estuaries and Coasts, authored by Dauphin Island Sea Lab scientists Dr. Ken Heck and Dr. John Valentine, turns this conventional wisdom on its head, making the...A walking robot goes mountaineering
... higher centers of organization step in a process triggered by the human brain or, in case of the robot, by its infrared eye leading on to a simpler neural network. Because of the hierarchical organization adjustment of the gait can be achieved by changing only a few parameters. Other factors will be automati...Scientists find brown fat master switch
...egelman lab. Further analysis showed that PRDM16 triggered formation of brown fat cells in part by turning on a metabolic pathway controlled by PGC-1alpha, which was discovered in Spiegelman's lab, and the gene UCP1, which allows cells to release large amounts of energy as heat. If continued research demon...Satellite survey links tropical park fires with poverty and corruption
... and two parks in Indonesia where active volcanoes triggered the MODIS fire detection algorithm, he said. With fire frequency data in hand, researchers developed a set of social and economic indicators reflecting the level of poverty and corruption in each country. The Corruption Protection Index was provided ...Scientists gain important insights into acute promyelocytic leukemia
...ed PML/RARA-induced transcriptional repression and triggered APL differentiation only when RXR was in a complex with PML/RARA. In addition, PML/RARA promoted posttranslational modifications of RXR, including its sumoylation, a modification that triggers transcriptional repression for RXR and many other transcr...Tiny tweezers and yeast help St. Jude show how cancer drug works
...evented the replication fork from advancing, which triggered cell death, Bjornsti said. We decided to test this model by studying the effect of camptothecin on DNA in yeast cells during the process of gene expression. During gene expression, the DNA strands are separated so the cell can copy the genetic inform...Malaria-resistant mosquitoes battle disease with 'molecular warhead'
...ite that causes malaria, a biochemical reaction is triggered that physically transforms TEP1 into an active state capable of grabbing on to the parasites surface and targeting it for termination. In a study appearing online this week in the Proceedings of the National Academy of Sciences , the UT Southweste...Antibody linked to MS significantly higher in spinal fluid of blacks
...etermining factor. Scientists believe MS is likely triggered by a bacterial or viral infection. The infection causes an abnormal response in the immune system that misdirects the body's defenses against myelin, a protective sheath that surrounds many nerve cells. To help clinch a diagnosis of MS, clinicians o...Early environmental exposure may accelerate age-related neurodegeneration
... it points to a possible role of common mechanisms triggered by iron and paraquat as important in PD, and suggests that therapies that block their effects would be worth testing in patients, says Marie-Francoise Chesselet, MD, PhD, of UCLA, who did not participate in the study. Ten-day-old mice were fed iron...Scripps research scientists show protein accelerates breast cancer progression in animal models
...s progress through stages of increasing malignancy triggered by mutations that promote their growth, said Thomas Deuel, the Scripps Research scientist whose laboratory made the discovery. The major finding of our study demonstrates both in vivo and in vitro that inappropriate expression of PTN not only promote...Herpes virus hijacks DNA repair process
...ge response, ATM and H2AX. The viral protein that triggered this inappropriate activation, orf36, is a kinase, a type of protein that chemically modifies other molecules to activate different processes or transmit signals. Genetic comparisons with several human herpes viruses revealed kinases similar to orf36...News tips from the Journal of Neuroscience
...fate proteoglycans. These astrocytic events can be triggered by activation of the epidermal growth factor receptor (EGFR); thus, Erschbamer et al. tested the potential benefit of permanently blocking the receptor after SCI. Rats received a contusion injury, and for 14 d received intrathecal injection of either......al differentiation cues. Buildup of p57 Kip2 also triggered expression of early gene markers of myelination. When the authors knocked down expression of p57 Kip2 using RNA silencing, OPC proliferation increased markedly, and differentiation ceased. Thus, p57 Kip2 fulfills the criteria for the primary compon...