Estrogen protects male rats from aortic aneurysms
...male and female rats with elastase, an enzyme that triggers an uncontrolled inflammatory reaction and creates ...eurysms," he says. "But understanding exactly what triggers them and how they develop could lead to an effective therapy someday. It also could help us identify...New center to map DNA of key lab mice
...nterparts in mice. By examining the environmental triggers of disease in genetically distinct mice, researchers can gain a better understanding of the relationship between genes and the environment in the development of disease in humans. Almost 200 human diseases are affected by exposure to environmental su...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...Yerkes-based studies demonstrate that this release triggers pair bond formation in monogamous species. (2 pm 3 pm) Yoland Smith, PhD, associate research professor and interim director of Emory's Neuroscience Graduate Program, and his research team: showed removing a group of proteins, known as Homer, incr...UCSD biologists discover chemical important in guiding visual system development
...these bursts of electrical activity. Knowing what triggers these waves of activity could make it possible to recreate them for therapeutic purposes, they said, and may shed light on disorders caused by their disruption. "The waves of neural activity in the developing visual system have a remarkably st...Findings challenge Darwinian theory
...hout the help of genes? Genetics aren't the only triggers for the traits a species develops, according to findings from a University of Alberta professor. The research challenges the classical Darwinian theory of evolution as being the sole explanation for how new life forms arise. In a paper published Oc...Stress impairs thinking via mania-linked enzyme
...rakes on PKC activity. The new study shows how PKC triggers cognitive symptoms in response to stress. When the stress-sensitive messenger chemical norepinephrine binds to receptors on cell membranes in the prefrontal cortex, it activates PKC through a cascade of events. The enzyme then travels out to the cell...Gene linked to enlargement of the factory where proteins are processed
...chinery. This increased demand for folded proteins triggers the so-called unfolded protein response (UPR), as ... which do the actual task of protein folding. XBP1 triggers the cell to make phosphatidylcholine, the major building block of the rows of membranes that make up...Initial sensor for p53 tumor-suppressing pathway identified
... end of the line in a vital signaling cascade that triggers cells with fatally damaged DNA to self-destruct so that they cannot cause cancer. The importance of the p53 pathway in preventing cancer cannot be overstated. Scientists know, for example, that in the majority of human cancers the p53 pathway has bee...U-M researcher examines the cell's housekeeping habits
... with baker's yeast, and some of the environmental triggers that start the process are being found. But there ...xtend the life span in rats, since near-starvation triggers more autophagy as the cells recycle parts of themselves for fuel. Sustained autophagy may also incre...Grants target better predictors for type 1 diabetes
...adults who have it. "We look at what environmental triggers might be involved, the outcome of the gene-environment interaction and messenger RNA and protein levels. You have to look at it that way. In the end, we want to put everything together and integrate that information into a predictive test. That is th...UCSD researchers find effective treatment for unusual fever syndrom caused by cold exposure
...clerosis to Alzheimer's disease." Because cold triggers fever in FCAS patients, in 2001 the UCSD team named the disease-causing protein they discovered "cryopyrin," which means icy fire. In their new studies with seven individuals, four afflicted with FCAS and three normal subjects, the investigators det...Molecular technique shows promise in destroying drug resistance in bacteria
...ramycin to prevent the actions of the protein that triggers plasmid reproduction. By thwarting that protein, apramycin blocked plasmid replication. The apramycin treatment was applied to bacterial cultures that were grown for 250 generations. By the end of the experiment, the plasmids no longer were present,...New tool highlights activity of key cellular signal
...ences, should speed identification of the signal's triggers and effects in normal processes and in conditions such as asthma, allergy, inflammation, lung disease and heart disease. The tool -- a special fluorescent protein -- probes the activity of cyclic AMP in living cells and represents biology's growing a...JCI table of contents, November 15 2004
.... The results demonstrate that muscular inactivity triggers the activation of P50 and Bcl3, which in turn may activate genes necessary for the development of atrophy. TITLE: Disruption of either the Nfkb1 or Bcl3 gene inhibits skeletal muscle atrophy. AUTHOR CONTACT:Susan C. Kandarian Depa...Studies suggest promising new directions for gallstone treatment
...iochemical conditions and gallstone formation then triggers inflammation, which is the major symptom of patients suffering from cholesterol gallstone disease (CGD). In their studies, the researchers sought to determine the role of a protein known as farnesoid X receptor (FXR), which controls genes whose prote...Stanford study links obesity to hormonal changes from lack of sleep
...leep loss leads to higher levels of a hormone that triggers appetite, lower levels of a hormone that tells you...ears ago and is primarily produced by the stomach, triggers appetite in humans: the more ghrelin you have, the more you want to eat. Leptin, a hormone pro...Children's Hospital Boston launches major genetic study of autism
... explore how they work and how brain-cell activity triggers them. These investigations may uncover other genes and biochemical pathways that underlie autism. Children and families enrolled in the Children's study also will be invited to take part in research at MIT's Department of Brain and Cognitive Scienc...Timing scavenging to prevent age-related blindness
...ular digestion functions. Perhaps the same signal triggers a cascade that initiates both concerted uptake and...dentify the protein that binds to the integrin and triggers these functions....Desires for fatty foods and alcohol share a chemical trigger
... chemical that stokes hunger for food and fat also triggers thirst for alcohol and may play a role in chronic drinking, according to a study led by Princeton University scientists. The study showed that rats injected with galanin, a natural signaling agent in the brain, chose to drink increasing quantities of......esearchers is the pattern of cellular signals that triggers the death of pigment stem cells, since melanoma is dangerous for the opposite reason melanocytes proliferate uncontrollably to form tumors and are hard to kill with treatment. "Preventing the graying of hair is not our goal," emphasizes David E. Fish...